Pharmacologic Substance
anagrelide Audio
[ an-ag-re-lide ]
Brand Names:
Agrylin
Effect:
Decreased Platelet Production
May Treat:
Polycythemia Vera; Thrombocytosis
More Information:
ChemID; DrugBank; DailyMed; PDR
Definitions related to anagrelide:
  • A drug that is used to decrease the number of platelets in the blood in order to prevent blood clotting.
    NCI Dictionary of Cancer Terms
    U.S. National Cancer Institute, 2021
  • A synthetic quinazoline derivative, Anagrelide reduces platelet production through a decrease in megakaryocyte maturation. Anagrelide inhibits cyclic AMP phosphodiesterase, as well as ADP- and collagen-induced platelet aggregation. At therapeutic doses, it does not influence white cell counts or coagulation parameters. Anagrelide is used for treatment of essential thrombocythemia to reduce elevated platelet counts and the risk of thrombosis. (NCI04)
    NCI
    U.S. National Cancer Institute, 2021
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