Pharmacologic Substance
aprepitant Audio
[ uh-preh-pih-tunt ]
Brand Names:
Cinvanti; Emend
Effect:
Decreased Brain Stem Substance P Activity; Decreased Kinin Activity; Emesis Suppression
May Prevent:
Nausea; Vomiting
More Information:
ChemID; DrugBank; DailyMed; PDR
Definitions related to aprepitant:
  • A drug used together with other drugs to prevent and control the nausea and vomiting caused by cancer treatment. It is also used to treat nausea and vomiting after surgery. It is a type of antiemetic and a type of substance P/neurokinin 1 receptor antagonist.
    NCI Dictionary of Cancer Terms
    U.S. National Cancer Institute, 2021
  • A morpholine neurokinin-1 (NK1) receptor antagonist that is used in the management of nausea and vomiting caused by DRUG THERAPY, and for the prevention of POSTOPERATIVE NAUSEA AND VOMITING.
    NLM Medical Subject Headings
    U.S. National Library of Medicine, 2025
  • A small molecule, high-affinity substance P antagonist (SPA) with antiemetic activity. Crossing the blood brain barrier, aprepitant binds selectively to the human substance P/neurokinin 1 receptor in the central nervous system (CNS), thereby inhibiting receptor binding of endogenous substance P and substance P-induced emesis. This agent has little or no affinity for serotonin type 3 (5-HT3), dopamine, and corticosteroid receptors.
    NCI
    U.S. National Cancer Institute, 2021
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