Pharmacologic Substance
azathioprine sodium Audio
[ ay-zuh-thy-oh-preen soh-dee-um ]
Effect:
Cellular Growth Phase Reduction; Decreased DNA Replication; Decreased Mitosis; Immunologic Activity Alteration
May Prevent:
Graft vs Host Disease
May Treat:
Arthritis, Rheumatoid; Colitis, Ulcerative; Crohn Disease; Lupus Erythematosus, Systemic; Multiple Sclerosis; Purpura, Thrombocytopenic, Idiopathic
More Information:
ChemID; DailyMed; PDR
Definitions related to azathioprine sodium:
  • A drug used to keep a patient from rejecting a transplanted kidney. It is also used in the treatment of rheumatoid arthritis that does not get better with other types of treatment. Azathioprine sodium blocks the growth of white blood cells and the synthesis of DNA, RNA, and protein. It is a type of immunosuppressant.
    NCI Dictionary of Cancer Terms
    U.S. National Cancer Institute, 2021
  • The sodium salt form of azathioprine, a pro-drug of purine analogue with immunosuppressive activity. Azathioprine is converted in vivo to its active metabolite 6-mercaptopurine (6-MP), which substitutes for the normal nucleoside and mistakenly gets incorporated into DNA sequences. This leads to inhibition of DNA, RNA, and protein synthesis. As a result, cell proliferation may be inhibited, particularly in lymphocytes and leukocytes.
    NCI
    U.S. National Cancer Institute, 2021
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This content should not be used in place of medically-reviewed decision support reference material or professional medical advice. Some terms may have alternate or updated definitions not reflected in this set. The definitions on this page should not be considered complete or up to date.