Immunologic Factor
basiliximab
Brand Names:
Simulect
Effect:
Decreased Cytokine Activity; Decreased Lymphocyte Cell Production
May Prevent:
Graft vs Host Disease
More Information:
ChemID; DrugBank; DailyMed; PDR
Definitions related to basiliximab:
  • A chimeric murine-human monoclonal antibody that functions as an INTERLEUKIN 2 RECEPTOR antagonist by binding to the alpha chain (CD25 ANTIGEN) of the interleukin-2 receptor on the surface of activated T-LYMPHOCYTES. It is used in the prevention of acute graft rejection episodes in patients undergoing renal transplantation.
    NLM Medical Subject Headings
    U.S. National Library of Medicine, 2025
  • A recombinant, chimeric, human-murine monoclonal antibody directed against the alpha subunit of the interleukin-2 receptor (IL-2R alpha) with immunosuppressant activity. Basiliximab selectively binds to and blocks IL-2R alpha, expressed on the surface of activated T-lymphocytes, thereby preventing interleukin-2 binding and inhibiting the interleukin-2-mediated activation of lymphocytes.
    NCI
    U.S. National Cancer Institute, 2021
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