Pharmacologic Substance
bromocriptine
[ broh-muh-krip-teen ]
Brand Names:
Cycloset; Parlodel
Effect:
Decreased Growth Hormone Secretion; Decreased Prolactin Secretion; Increased Dopamine Activity
May Treat:
Acromegaly; Adenoma; Amenorrhea; Galactorrhea; Hyperprolactinemia; Hypogonadism; Infertility; Neuroleptic Malignant Syndrome; Parkinson Disease
More Information:
ChemID; DrugBank; DailyMed; PDR
Definitions related to bromocriptine:
  • A semisynthetic ergotamine alkaloid that is a dopamine D2 agonist. It suppresses prolactin secretion.
    NLM Medical Subject Headings
    U.S. National Library of Medicine, 2025
  • A semisynthetic, ergot alkaloid with antiparkinson and lactation inhibitory activities. Bromocriptine selectively binds to and activates the postsynaptic dopamine D2-like receptors in the corpus striatum of the central nervous system (CNS). D2-like receptors are coupled to inhibitory G-proteins, which inhibit adenylyl cyclase, thereby preventing signal transduction mediated via cAMP and leading to an inhibitory effect on neurotransmission. This improves Parkinson symptoms, such as dyskinesia. Bromocriptine also has an inhibitory effect on the anterior pituitary gland, which results in blockage of prolactin secretion, thereby suppressing lactation.
    NCI
    U.S. National Cancer Institute, 2021
  • D2 dopamine agonist used as a prolactin inhibitor.
    CRISP Thesaurus
    National Institutes of Health, 2006
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