Antibiotic
demeclocycline
[ dem-uh-kloh-sahy-kleen ]
Brand Names:
Declomycin
Effect:
Cell Membrane Alteration; Decreased Mitosis; Decreased Protein Synthesis
May Treat:
Acne Vulgaris; Actinomycosis; Campylobacter Infections; Cholera; Clostridium Infections; Gonorrhea; Inappropriate ADH Syndrome; Lymphogranuloma Venereum; Plague; Pneumonia, Mycoplasma; Psittacosis; Rocky Mountain Spotted Fever; Trachoma; Typhoid Fever; Urinary Tract Infections; Whooping Cough
More Information:
ChemID; DrugBank; DailyMed; PDR
Definitions related to demeclocycline:
  • A semi-synthetic, broad-spectrum naphthacene antibiotic produced by the bacterium Streptomyces aureofaciens. Demeclocycline binds to bacterial 30S ribosomal subunit and prevents binding of aminoacyl-tRNA to the mRNA-ribosome complex, thereby inhibiting protein synthesis. Demeclocycline also inhibits the effect of vasopressin on the renal tubules, thereby causing diuresis.
    NCI
    U.S. National Cancer Institute, 2021
  • A TETRACYCLINE analog having a 7-chloro and a 6-methyl. Because it is excreted more slowly than tetracycline, it maintains effective blood levels for longer periods of time.
    NLM Medical Subject Headings
    U.S. National Library of Medicine, 2025
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