Pharmacologic Substance
diphenoxylate
[ dahy-fen-ok-suh-leyt ]
Brand Names:
Lomotil; Lonox
Effect:
Decreased GI Motility
May Treat:
Diarrhea
More Information:
ChemID; DrugBank; DailyMed; PDR
Definitions related to diphenoxylate:
  • A MEPERIDINE congener used as an antidiarrheal, usually in combination with ATROPINE. At high doses, it acts like morphine. Its unesterified metabolite difenoxin has similar properties and is used similarly. It has little or no analgesic activity.
    NLM Medical Subject Headings
    U.S. National Library of Medicine, 2025
  • A piperidine derivate, chemically related to narcotic meperidine with antidiarrheal activity and devoid of central nervous system (CNS) activity. Diphenoxylate acts on opioid receptors in the gastrointestinal tract, thereby decreasing gastrointestinal motility and causing constipation or preventing diarrhea.
    NCI
    U.S. National Cancer Institute, 2021
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