Pharmacologic Substance
eribulin mesylate Audio
[ er-eh-byoo-lin meh-zih-layt ]
Effect:
Decreased Cellular Migration; Decreased Mitosis; Increased Cellular Death; Microtubule Inhibition
May Treat:
Breast Neoplasms; Liposarcoma
More Information:
ChemID; DailyMed; PDR
Definitions related to eribulin mesylate:
  • A drug used to treat metastatic breast cancer in patients who have already been treated with other chemotherapy. It is also being studied in the treatment of other types of cancer. Halaven may block cancer cell growth by stopping cell division. It belongs to the family of drugs called antitubulin agents.
    NCI Dictionary of Cancer Terms
    U.S. National Cancer Institute, 2021
  • The mesylate salt of a synthetic analogue of halichondrin B, a substance derived from a marine sponge (Lissodendoryx sp.) with antineoplastic activity. Eribulin binds to the vinca domain of tubulin and inhibits the polymerization of tubulin and the assembly of microtubules, resulting in inhibition of mitotic spindle assembly, induction of cell cycle arrest at G2/M phase, and, potentially, tumor regression.
    NCI
    U.S. National Cancer Institute, 2021
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