Pharmacologic Substance
esomeprazole
Brand Names:
Nexium; Vimovo
Effect:
Inhibition Gastric Acid Secretion
May Prevent:
Stomach Ulcer
May Treat:
Duodenal Ulcer; Esophagitis; Gastroesophageal Reflux; Heartburn; Helicobacter Infections; Zollinger-Ellison Syndrome
More Information:
ChemID; DrugBank; DailyMed; PDR
Definitions related to esomeprazole:
  • A drug that blocks acid from being made in the stomach. It is used to treat acid reflux disease and to prevent certain types of gastrointestinal ulcers. Esomeprazole is being studied in the prevention of esophageal cancer and in the treatment of other conditions, including side effects of chemotherapy. It is a type of anti-ulcer agent.
    NCI Dictionary of Cancer Terms
    U.S. National Cancer Institute, 2021
  • The S-isomer of omeprazole, with gastric proton pump inhibitor activity. In the acidic compartment of parietal cells, esomeprazole is protonated and converted into the active achiral sulfenamide; the active sulfenamide forms one or more covalent disulfide bonds with the proton pump hydrogen-potassium adenosine triphosphatase (H+/K+ ATPase), thereby inhibiting its activity and the parietal cell secretion of H+ ions into the gastric lumen, the final step in gastric acid production. H+/K+ ATPase is an integral membrane protein of the gastric parietal cell.
    NCI
    U.S. National Cancer Institute, 2021
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This content should not be used in place of medically-reviewed decision support reference material or professional medical advice. Some terms may have alternate or updated definitions not reflected in this set. The definitions on this page should not be considered complete or up to date.