Pharmacologic Substance
fomepizole
Effect:
Decreased Organic Ion Synthesis
May Prevent:
Acidosis; Drug-Related Side Effects and Adverse Reactions; Renal Insufficiency; Vision Disorders
May Treat:
Drug-Related Side Effects and Adverse Reactions
More Information:
ChemID; DrugBank; DailyMed; PDR
Definitions related to fomepizole:
  • A pyrazole and competitive inhibitor of ALCOHOL DEHYDROGENASE that is used for the treatment of poisoning by ETHYLENE GLYCOL or METHANOL.
    NLM Medical Subject Headings
    U.S. National Library of Medicine, 2025
  • A pyrazole with competitive alcohol dehydrogenase inhibitor activity. Fomepizole prevents the metabolism of ethylene glycol and methanol by alcohol dehydrogenase, thereby inhibiting the formation of their toxic metabolites, glycolate and oxalate (from ethylene glycol), and formic acid (from methanol). Fomepizole is indicated for use as an antidote in ethylene glycol and methanol poisoning. (NCI05)
    NCI
    U.S. National Cancer Institute, 2021
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This content should not be used in place of medically-reviewed decision support reference material or professional medical advice. Some terms may have alternate or updated definitions not reflected in this set. The definitions on this page should not be considered complete or up to date.