Pharmacologic Substance
fosaprepitant dimeglumine Audio
[ fos-uh-preh-pih-tunt dy-meg-loo-meen ]
Effect:
Emesis Suppression
May Prevent:
Nausea; Vomiting
More Information:
ChemID; DailyMed; PDR
Definitions related to fosaprepitant dimeglumine:
  • A drug used together with other drugs to prevent and control nausea and vomiting caused by cancer treatment. It is given in a vein. It is a type of antiemetic and a type of substance P/neurokinin 1 receptor antagonist.
    NCI Dictionary of Cancer Terms
    U.S. National Cancer Institute, 2021
  • The dimeglumine salt form of fosaprepitant, the water-soluble, N-phosphorylated prodrug of aprepitant, with antiemetic activity. Upon intravenous administration and rapid conversion to aprepitant, this agent binds selectively to the human substance P/neurokinin 1 (NK1) receptors in the central nervous system (CNS). This inhibits receptor binding of the endogenous substance P and prevents substance P-induced emesis.
    NCI
    U.S. National Cancer Institute, 2021
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This content should not be used in place of medically-reviewed decision support reference material or professional medical advice. Some terms may have alternate or updated definitions not reflected in this set. The definitions on this page should not be considered complete or up to date.