Genetic Function
hypomethylation
Definitions related to hypomethylation:
  • An epigenetic process that either inhibits DNA methyltransferase activity or promotes DNA demethylase activity, and results in a net loss of 5-methylcytosines and a net gain of unmethylated cytosine nucleotides either in specific repetitive DNA sequences or across the bulk of the genome. This phenomenon is associated with aging, genomic instability and tumorigenesis.
    NCI
    U.S. National Cancer Institute, 2021
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