Pharmacologic Substance
isosorbide dinitrate
Brand Names:
Bidil; Dilatrate; Isochron; IsoDitrate; Isordil
Effect:
Arterial Vasodilation; Decreased Blood Pressure; Decreased Vascular Smooth Muscle Tone; Increased Nitric Oxide Activity; Venous Vasodilation
May Prevent:
Angina Pectoris
May Treat:
Angina Pectoris; Coronary Disease; Cyanosis; Esophageal Spasm, Diffuse; Gastroesophageal Reflux; Heart Failure; Poisoning
More Information:
ChemID; DrugBank; DailyMed; PDR
Definitions related to isosorbide dinitrate:
  • A vasodilator used in the treatment of ANGINA PECTORIS. Its actions are similar to NITROGLYCERIN but with a slower onset of action.
    NLM Medical Subject Headings
    U.S. National Library of Medicine, 2025
  • The dinitrate salt form of isosorbide, an organic nitrate with vasodilator activity. Isosorbide dinitrate relaxes vascular smooth muscle by formation of the free radical nitric oxide (NO), which is identical to the endothelium-derived relaxing factor (EDRF). NO activates guanylyl cyclase, thereby increasing the synthesis of cGMP within smooth muscle, resulting in dephosphorylation of light chain myosin and relaxation of peripheral arteries and veins. In addition, isosorbide dinitrate relaxes coronary arteries, thereby increasing the blood circulation through the ischemic area. (NCI05)
    NCI
    U.S. National Cancer Institute, 2021
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