Disease or Syndrome
leukoencephalopathy
Subclass of:
Brain Diseases
Definitions related to leukoencephalopathy:
  • This term describes abnormality of the white matter of the cerebrum resulting from damage to the myelin sheaths of nerve cells.
    Human Phenotype Ontology (HPO)
    The Human Phenotype Ontology Project, 2025
  • White matter changes first described in children with leukemia, associated with radiation and chemotherapy injury, often associated with methotrexate; pathologically characterised by diffuse reactive astrocytosis with multiple areas of necrotic foci without inflammation.
    NCI
    U.S. National Cancer Institute, 2021
  • (leukoencephalopathies) Any of various diseases affecting the white matter of the central nervous system.
    NLM Medical Subject Headings
    U.S. National Library of Medicine, 2025
  • A disorder characterized by diffuse reactive astrocytosis with multiple areas of necrotic foci without inflammation.
    Common Terminology Criteria for Adverse Events
    U.S. National Institutes of Health, 2021
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This content should not be used in place of medically-reviewed decision support reference material or professional medical advice. Some terms may have alternate or updated definitions not reflected in this set. The definitions on this page should not be considered complete or up to date.