Cell Function
pyroptosis
Subclass of:
Apoptosis
Definitions related to pyroptosis:
  • A caspase-1-dependent cell death subroutine that is associated with the generation of pyrogenic mediators such as IL-1beta and IL-18.
    Gene Ontology Dictionary
    Gene Ontology Consortium, 2021
  • An inflammatory form of programmed cell death characterized by caspase-dependent formation of plasma-membrane pores, which leads to pathological changes in osmotic potential that ultimately result in cellular lysis and release of pro-inflammatory cytokines. It occurs most frequently following infection with intracellular pathogens, but also has a role in tumor suppression and the initiation of anti-tumor immune responses, as well as in autoimmune and cardiovascular diseases.
    NCI
    U.S. National Cancer Institute, 2021
  • Type of programmed cell death associated with infection by intracellular pathogens. It is characterized by INFLAMMASOME formation; activation of CASPASE 1; and CYTOKINES mediated inflammation.
    NLM Medical Subject Headings
    U.S. National Library of Medicine, 2025
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This content should not be used in place of medically-reviewed decision support reference material or professional medical advice. Some terms may have alternate or updated definitions not reflected in this set. The definitions on this page should not be considered complete or up to date.