Biologically Active Substance
shelterin
Subclass of:
Telomere-Binding Proteins; Nucleoproteins; telomere
Definitions related to shelterin:
  • A protein complex that is physically bound to chromosomal telomeres and plays a role in both the elongation and maintenance of telomeric repeats.
    NCI
    U.S. National Cancer Institute, 2021
  • (shelterin complex) A TELOMERE cap complex consisting of telomere-specific proteins in association with telomeric DNA such as telomeric dsDNA-sDNA junction. They are involved in the protection of chromosome ends and TELOMERASE regulation and play a role in CELLULAR SENESCENCE and ageing-related pathology. In general it consists of six mostly TELOMERE-BINDING PROTEINS (POT1, RAP1, TIN2, TPP1, TRF1, and TRF2).
    NLM Medical Subject Headings
    U.S. National Library of Medicine, 2025
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