Pharmacologic Substance
sparfosic acid
spar·fo·sic ac·id
Definitions related to sparfosic acid:
  • A stable transition state analogue for an aspartate transcarbamylase-catalyzed reaction with antineoplastic activity. Sparfosic acid is a stable transition analogue of the activated complex for the reaction catalyzed by aspartate transcarbamylase, the first step in the pyrimidine biosynthetic pathway. This agent inhibits de novo pyrimidine biosynthesis and increases the extent to which fluorouracil metabolites are incorporated into RNA.
    NCI
    U.S. National Cancer Institute, 2021
  • An anticancer drug that is being studied to increase the effectiveness of the chemotherapy drug fluorouracil.
    NCI Dictionary of Cancer Terms
    U.S. National Cancer Institute, 2021
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