Pharmacologic Substance
thiethylperazine Audio
[ thy-eh-thul-payr-uh-zeen ]
Effect:
Decreased Central Nervous System Dopamine Activity; Decreased Central Nervous System Norepinephrine Activity; Emesis Suppression; Hypothalamic Endocrine Activity Alteration
May Treat:
Nausea; Vertigo; Vomiting
Definitions related to thiethylperazine:
  • A dopamine antagonist that is particularly useful in treating the nausea and vomiting associated with anesthesia, mildly emetic cancer chemotherapy agents, radiation therapy, and toxins. This piperazine phenothiazine does not prevent vertigo or motion sickness. (From AMA Drug Evaluations Annual, 1994, p457)
    NLM Medical Subject Headings
    U.S. National Library of Medicine, 2021
  • A drug used to prevent or reduce nausea and vomiting. It belongs to the families of drugs called antiemetics and phenothiazines.
    NCI Dictionary of Cancer Terms
    U.S. National Cancer Institute, 2021
  • A piperazine phenothiazine derivative and a dopamine antagonist used as antiemetic. Thiethylperazine blocks postsynaptic dopamine 2 (D2) receptors in the medullary chemoreceptor trigger zone (CTZ), thereby decreasing stimulation of the vomiting center in the brain. Peripherally, thiethylperazine blocks the vagus nerve in the gastrointestinal tract. In addition, this agent also shows antagonistic activities mediated through muscarinic receptors, H1-receptors, and alpha(1)-receptors.
    NCI Thesaurus
    U.S. National Cancer Institute, 2021
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