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Australian Journal of General Practice Aug 2021Umbilical granuloma is a common condition in infants. The aim of this study was to systematically review randomised controlled trials (RCTs) of topical treatment options...
BACKGROUND AND OBJECTIVES
Umbilical granuloma is a common condition in infants. The aim of this study was to systematically review randomised controlled trials (RCTs) of topical treatment options for umbilical granuloma.
METHOD
PubMed, Embase, Cochrane Library, Google Scholar and grey literature were searched in September 2020.
RESULTS
Eleven RCTs (n = 890) that studied the use of silver nitrate, topical steroids, ethanol wipes, electrocautery, cryocautery, copper sulphate and common salt were included. Common salt achieved resolution in >90% of cases in five studies and 54-80% in two studies. Topical steroids, silver nitrate, copper sulphate and cryocautery achieved resolution in >90% and ethanol wipes in 50-65% of cases. Local side effects reported with topical steroids, silver nitrate, cryocautery and electrocautery varied in each study. Salt application did not cause side effects. The risk of bias was high in many RCTs.
DISCUSSION
While the majority of the interventions were effective in treating umbilical granuloma, salt application appears to be simple and effective, with minimal complications.
Topics: Humans; Infant; Administration, Topical; Granuloma; Randomized Controlled Trials as Topic
PubMed: 34333576
DOI: 10.31128/AJGP-04-20-5371 -
Journal of Burn Care & Research :... 2015After a burn injury, superficial partial-thickness burn wounds may progress to deep partial-thickness or full-thickness burn wounds, if kept untreated. This phenomenon... (Review)
Review
After a burn injury, superficial partial-thickness burn wounds may progress to deep partial-thickness or full-thickness burn wounds, if kept untreated. This phenomenon is called secondary burn wound progression or conversion. Burn wound depth is an important determinant of patient morbidity and mortality. Therefore, reduction or even the prevention of secondary burn wound progression is one goal of the acute care of burned patients. The objective of this study was to review preclinical approaches evaluating therapies to reduce burn wound progression. A systematic review of experimental approaches in animals that aim at reducing or preventing secondary burn wound progression was performed in accordance with the Preferred Reporting Items for Systematic Reviews and Meta Analysis (PRISMA) guidelines. The selected references consist of all the peer-reviewed studies performed in vivo in animals and review articles published in English, German, Italian, Spanish, or French language relevant to the topic of secondary burn wound progression. We searched MEDLINE, Cochrane Library, and Google Scholar including all the articles published from the beginning of notations to the present. The search was conducted between May 3, 2012 and December 26, 2013. We included 29 experimental studies in this review, investigating agents that maintain or increase local perfusion conditions, as well as agents that exhibit an anti-coagulatory, an anti-inflammatory, or an anti-apoptotic property. Warm water, simvastatin, EPO, or cerium nitrate may represent particularly promising approaches for the translation into clinical use in the near future. This review demonstrates promising experimental approaches that might reduce secondary burn wound progression. Nevertheless, a translation into clinical application needs to confirm the results compiled in experimental animal studies.
Topics: Animals; Anti-Bacterial Agents; Antibiotic Prophylaxis; Burns; Disease Models, Animal; Graft Survival; Silver Sulfadiazine; Skin; Wound Healing; Wound Infection
PubMed: 25094011
DOI: 10.1097/BCR.0000000000000131 -
Acta Otorhinolaryngologica Italica :... Aug 2019
Meta-Analysis
Topics: Adult; Cautery; Databases, Factual; Drug Combinations; Electrocoagulation; Embolism; Endoscopy; Endovascular Procedures; Epistaxis; Gelatin Sponge, Absorbable; Humans; Laser Therapy; Silver Nitrate; Tranexamic Acid
PubMed: 30933179
DOI: 10.14639/0392-100X-2155