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QJM : Monthly Journal of the... May 2019
Topics: Acremonium; Alveolitis, Extrinsic Allergic; Bronchial Provocation Tests; Humans; Humidifiers; Lung; Male; Middle Aged; Mycoses
PubMed: 30847489
DOI: 10.1093/qjmed/hcz061 -
Studies in Mycology Jun 2023is acknowledged as a highly ubiquitous genus including saprobic, parasitic, or endophytic fungi that inhabit a variety of environments. Species of this genus are...
is acknowledged as a highly ubiquitous genus including saprobic, parasitic, or endophytic fungi that inhabit a variety of environments. Species of this genus are extensively exploited in industrial, commercial, pharmaceutical, and biocontrol applications, and proved to be a rich source of novel and bioactive secondary metabolites. has been recognised as a taxonomically difficult group of ascomycetes, due to the reduced and high plasticity of morphological characters, wide ecological distribution and substrate range. Recent advances in molecular phylogenies, revealed that is highly polyphyletic and members of belong to at least three distinct orders of , of which numerous orders, families and genera with acremonium-like morphs remain undefined. To infer the phylogenetic relationships and establish a natural classification for acremonium-like taxa, systematic analyses were conducted based on a large number of cultures with a global distribution and varied substrates. A total of 633 cultures with acremonium-like morphology, including 261 ex-type cultures from 89 countries and a variety of substrates including soil, plants, fungi, humans, insects, air, and water were examined. An overview phylogenetic tree based on three loci (ITS, LSU, ) was generated to delimit the orders and families. Separate trees based on a combined analysis of four loci (ITS, LSU, , ) were used to delimit species at generic and family levels. Combined with the morphological features, host associations and ecological analyses, acremonium-like species evaluated in the present study are currently assigned to 63 genera, and 14 families in and , mainly in the families , and and five new hypocrealean families, namely , , , and . Among them, 17 new genera and 63 new combinations are proposed, with descriptions of 65 new species. Furthermore, one epitype and one neotype are designated to stabilise the taxonomy and use of older names. Results of this study demonstrated that most species of grouped in genera of , including the type . . A phylogenetic backbone tree is provided for , in which 183 species are recognised and 39 well-supported genera are resolved, including 10 new genera. Additionally, and are proposed as potential DNA barcodes for the identification of taxa in . L.W. Hou, L. Cai & Crous, L.W. Hou, L. Cai & Crous, L.W. Hou, L. Cai & Crous, L.W. Hou, L. Cai & Crous, L.W. Hou, L. Cai & Crous. : L.W. Hou, L. Cai & Crous, L.W. Hou, L. Cai & Crous, L.W. Hou, L. Cai & Crous, L.W. Hou, L. Cai & Crous, L.W. Hou, L. Cai & Crous, L.W. Hou, L. Cai & Crous, L.W. Hou, L. Cai & Crous, L.W. Hou, L. Cai & Crous, L.W. Hou, L. Cai & Crous, L.W. Hou, L. Cai & Crous; L.W. Hou, L. Cai & Crous; L.W. Hou, L. Cai & Crous; L.W. Hou, L. Cai & Crous; L.W. Hou, L. Cai & Crous, L.W. Hou, L. Cai & Crous; L.W. Hou, L. Cai & Crous; L.W. Hou, L. Cai & Crous. L.W. Hou, L. Cai & Crous, L.W. Hou, L. Cai & Crous, L.W. Hou, L. Cai & Crous, L.W. Hou, L. Cai & Crous, L.W. Hou, L. Cai & Crous, L.W. Hou, Rämä, L. Cai & Crous, L.W. Hou, L. Cai & Crous, L.W. Hou, L. Cai & Crous, L.W. Hou, Rämä, L. Cai & Crous, L.W. Hou, L. Cai & Crous, K. Fletcher, F.C. Küpper & P. van West, L.W. Hou, L. Cai & Crous, L.W. Hou, Rämä, L. Cai & Crous, L.W. Hou, L. Cai & Crous, L.W. Hou, L. Cai & Crous, L.W. Hou, L. Cai & Crous, L.W. Hou, L. Cai & Crous, L.W. Hou, L. Cai & Crous, L.W. Hou, L. Cai & Crous, L.W. Hou, L. Cai & Crous, L.W. Hou, L. Cai & Crous, L.W. Hou, L. Cai & Crous, L.W. Hou, L. Cai & Crous, L.W. Hou, L. Cai & Crous, Lechat & J. Fourn., L.W. Hou, L. Cai & Crous, L.W. Hou, L. Cai & Crous, L.W. Hou, L. Cai, Rämä & Crous, L.W. Hou, L. Cai & Crous, L.W. Hou, L. Cai & Crous, L.W. Hou, L. Cai & Crous, L.W. Hou, L. Cai & Crous, L.W. Hou, L. Cai & Crous, L.W. Hou, L. Cai & Crous, L.W. Hou, L. Cai & Crous, L.W. Hou, L. Cai & Crous, L.W. Hou, L. Cai & Crous, L.W. Hou, L. Cai & Crous, L.W. Hou, L. Cai & Crous, L.W. Hou, L. Cai & Crous, L.W. Hou, L. Cai & Crous; L.W. Hou, L. Cai & Crous; L.W. Hou, L. Cai & Crous; L.W. Hou, L. Cai & Crous, L.W. Hou, L. Cai & Crous; L.W. Hou, L. Cai & Crous, L.W. Hou, L. Cai & Crous; Trichothecium hongkongense L.W. Hou, L. Cai & Crous; L.W. Hou, L. Cai & Crous, L.W. Hou, L. Cai & Crous; L.W. Hou, L. Cai & Crous, L.W. Hou, L. Cai & Crous, L.W. Hou, L. Cai & Crous, L.W. Hou, L. Cai & Crous, L.W. Hou, L. Cai & Crous, L.W. Hou, L. Cai & Crous, L.W. Hou, L. Cai & Crous, L.W. Hou, L. Cai & Crous, L.W. Hou, L. Cai & Crous, L.W. Hou, L. Cai & Crous, L.W. Hou, L. Cai & Crous, L.W. Hou, L. Cai & Crous, L.W. Hou, L. Cai & Crous; L.W. Hou, L. Cai & Crous, L.W. Hou, L. Cai & Crous. (Sukapure & Thirum.) L.W. Hou, L. Cai & Crous, (Malloch) L.W. Hou, L. Cai & Crous, (Tad. Ito .) L.W. Hou, L. Cai & Crous, (W. Gams) L.W. Hou, L. Cai & Crous, (Negroni) L.W. Hou, L. Cai & Crous, (Sigler ) L.W. Hou, L. Cai & Crous, (Pers.) L.W. Hou, L. Cai & Crous, (Summerb. ) L.W. Hou, L. Cai & Crous, (A. Giraldo et al.) L.W. Hou, L. Cai & Crous, (W. Gams & Lodha) L.W. Hou, L. Cai & Crous, (Gams) L.W. Hou, L. Cai & Crous, (Berk. & Broome) L.W. Hou, L. Cai & Crous, (Thirum. & Sukapure) L.W. Hou, L. Cai & Crous, (W. Gams) L.W. Hou, L. Cai & Crous, (Malloch & Cain) L.W. Hou, L. Cai & Crous, (Malloch & Cain) L.W. Hou, L. Cai & Crous, (C.A. Jørg.) L.W. Hou, L. Cai & Crous, (Lechat & J. Fourn.) L.W. Hou, L. Cai & Crous, (W. Gams) L.W. Hou, L. Cai & Crous, (Lechat & Gardiennet) L.W. Hou, L. Cai & Crous, (P. Karst.) L.W. Hou, L. Cai & Crous, (W. Gams) L.W. Hou, L. Cai & Crous, (Samuels) L.W. Hou, L. Cai & Crous, (Samuels) L.W. Hou, L. Cai & Crous, (Lechat & J. Fourn.) L.W. Hou, L. Cai & Crous, (Berk. & Broome) L.W. Hou, L. Cai & Crous, (R.F. Castañeda) L.W. Hou, L. Cai & Crous, (Sawada) L.W. Hou, L. Cai & Crous, (Jaap) L.W. Hou, L. Cai & Crous, (A. Giraldo ) L.W. Hou, L. Cai & Crous, (A. Giraldo .) L.W. Hou, L. Cai & Crous, (Samuels) L.W. Hou, L. Cai & Crous, (Samuels)L.W. Hou, L. Cai & Crous, (J.F. Li .) L.W. Hou, L. Cai & Crous, (Fuckel) L.W. Hou, L. Cai & Crous, (Lechat & J. Fourn.) L.W. Hou, L. Cai & Crous, (W. Gams) L.W. Hou, L. Cai & Crous, (Matr.)L.W. Hou, L. Cai & Crous, (Gams & Sivasith.) L.W. Hou, L. Cai & Crous, (Nicot) L.W. Hou, L. Cai & Crous, (W. Gams & Veenb.-Rijks) L.W. Hou, L. Cai & Crous, (A. Giraldo .) L.W. Hou, L. Cai & Crous, (A. Giraldo ) L.W. Hou, L. Cai & Crous, (Samuels) L.W. Hou, L. Cai & Crous, (Nicot) L.W. Hou, L. Cai & Crous, (W. Gams) L.W. Hou, L. Cai & Crous, (A. Giraldo ) L.W. Hou, L. Cai & Crous, (A. Giraldo ) L.W. Hou, L. Cai & Crous, (Petch) L.W. Hou, L. Cai & Crous; (W. Gams & J. Lacey) L.W. Hou, L. Cai & Crous; (W. Gams) L.W. Hou, L. Cai & Crous; : (W. Gams) L.W. Hou, L. Cai & Crous; (W. Gams) L.W. Hou, L. Cai & Crous; (Sukapure & Thirum.) L.W. Hou, L. Cai & Crous; (K.L. Pang .) L.W. Hou, L. Cai & Crous; (W. Gams) L.W. Hou, L. Cai & Crous; (W. Gams) L.W. Hou, L. Cai & Crous, (W. Gams) L.W. Hou, L. Cai & Crous; (W. Gams .) L.W. Hou, L. Cai & Crous; (W. Gams) L.W. Hou, L. Cai & Crous, (Sukapure & Thirum.) L.W. Hou, L. Cai & Crous; (C.H. Dickinson) L.W. Hou, L. Cai & Crous, (G. Sm.) L.W. Hou, L. Cai & Crous. J.C. Schmidt ex Fr. Matr. Hou LW, Giraldo A, Groenewald JZ, Rämä T, Summerbell RC, Zang P, Cai L, Crous PW (2023). Redisposition of acremonium-like fungi in . : 23-203. doi: 10.3114/sim.2023.105.02.
PubMed: 38895703
DOI: 10.3114/sim.2023.105.02 -
Mycoses Nov 2020The genera Acremonium and Sarocladium comprise a high diversity of morphologically and genetically related fungi generally found in the environment, although a few... (Review)
Review
The genera Acremonium and Sarocladium comprise a high diversity of morphologically and genetically related fungi generally found in the environment, although a few species, mainly Sarocladium kiliense and Acremonium egyptiacum, can also be involved in many human infections. Clinical management of opportunistic infections caused by these fungi is very complex, since their correct identification is unreliable, and they generally show poor antifungal response. More than 300 clinical cases involving a broad range of Acremonium/Sarocladium infections have so far been published, and with this review we aim to compile and provide a detailed overview of the current knowledge on Acremonium/Sarocladium human infections in terms of presentation, diagnosis, treatments and prognoses. We also aim to summarise and discuss the data currently available on their antifungal susceptibility, emphasising the promising results obtained with voriconazole as well as their impact in terms of animal infections.
Topics: Acremonium; Animals; Antifungal Agents; Arthritis; Blood; Central Nervous System Infections; Dermatomycoses; Drug Resistance, Fungal; Endocarditis; Eye Infections; Humans; Hypocreales; Invasive Fungal Infections; Mycetoma; Mycoses; Onychomycosis; Opportunistic Infections; Osteomyelitis; Peritonitis; Respiratory Tract Infections; Voriconazole
PubMed: 33090564
DOI: 10.1111/myc.13169 -
Applied Microbiology and Biotechnology Dec 2022Antibiotics are antibacterial compounds that interfere with bacterial growth, without harming the infected eukaryotic host. Among the clinical agents, beta-lactams play... (Review)
Review
Antibiotics are antibacterial compounds that interfere with bacterial growth, without harming the infected eukaryotic host. Among the clinical agents, beta-lactams play a major role in treating infected humans and animals. However, the ever-increasing antibiotic resistance crisis is forcing the pharmaceutical industry to search for new antibacterial drugs to combat a range of current and potential multi-resistant bacterial pathogens. In this review, we provide an overview of the development, innovation, and current status of therapeutic applications for beta-lactams with a focus on semi-synthetic cephalosporins. Cephalosporin C (CPC), which is a natural secondary metabolite from the filamentous fungus Acremonium chrysogenum, plays a major and demanding role in both producing modern antibiotics and developing new ones. CPC serves as a core compound for producing semi-synthetic cephalosporins that can control infections with different resistance mechanisms. We therefore summarize our latest knowledge about the CPC biosynthetic pathway and its regulation in the fungal host. Finally, we describe how CPC serves as a key lead generation source for the in vitro and better, in vivo synthesis of 7-aminocephalosporanic acid (7-ACA), the major core compound for the pharmaceutical synthesis of current and future semi-synthetic cephalosporins. KEY POINTS: • Latest literature on cephalosporin generations • Biotechnical production of cephalosporins • In vivo production of 7-ACA.
Topics: Animals; Humans; Monobactams; Cephalosporins; Anti-Bacterial Agents; Drug Industry
PubMed: 36401643
DOI: 10.1007/s00253-022-12272-8 -
Mini Reviews in Medicinal Chemistry 2017Acremonium fungi have been isolated from various sources, such as soil, plants, and marine organisms. (Review)
Review
BACKGROUND
Acremonium fungi have been isolated from various sources, such as soil, plants, and marine organisms.
METHOD
The species in Acremonium have been proved to be rich sources of novel and bioactive secondary metabolites. Up to now, 356 metabolites belonging to steroids (6 compounds), terpenoids (86), meroterpenoids (66), polyketides (89), alkaloids (28), peptides (75), and miscellaneous types (6) have been isolated from Acremonium fungi. These metabolites displayed a wide range of biological activities including antimicrobial, cytotoxic, antitumor, immunosuppressive, antioxidant, antiinflammatory, antimalarial, phytotoxic, tremorgenic, antiviral, neuritogenic, insecticidal and enzymesinhibiting activities.
CONCLUSION
This review highlights the structures and bioactivities of the secondary metabolites from Acremonium fungi reported until July 2016.
Topics: Acremonium; Animals; Anti-Infective Agents; Anti-Inflammatory Agents, Non-Steroidal; Antimalarials; Antineoplastic Agents; Antioxidants; Antiviral Agents; Enzyme Inhibitors; Humans; Insecticides; Molecular Structure; Secondary Metabolism
PubMed: 27633747
DOI: 10.2174/1389557516666160914194134 -
Applied Microbiology and Biotechnology Oct 2022Cephalosporins are currently the most widely used antibiotics in clinical practice. The main strain used for the industrial production cephalosporin C (CPC) is... (Review)
Review
Cephalosporins are currently the most widely used antibiotics in clinical practice. The main strain used for the industrial production cephalosporin C (CPC) is Acremonium chrysogenum. CPC has the advantages of possessing a broad antibacterial spectrum and strong antibacterial activity. However, the yield and titer of cephalosporins obtained from A. chrysogenum are much lower than penicillin, which is also a β-lactam antibiotic produced by Penicillium chrysogenum. Molecular biology research into A. chrysogenum has focused on gene editing technologies, multi-omics research which has provided information on the differences between high- and low-yield strains, and metabolic engineering involving different functional genetic modifications and hierarchical network regulation to understand strain characteristics. Furthermore, optimization of the fermentation process is also reviewed as it provides the optimal environment to realize the full potential of strains. Combining rational design to control the metabolic network, high-throughput screening to improve the efficiency of obtaining high-performance strains, and real-time detection and controlling in the fermentation process will become the focus of future research in A. chrysogenum. This minireview provides a holistic and in-depth analysis of high-yield mechanisms and improves our understanding of the industrial value of A. chrysogenum. KEY POINTS: • Review of the advances in A. chrysogenum characteristics improvement and process optimization • Elucidate the molecular bases of the mechanisms that control cephalosporin C biosynthesis and gene expression in A. chrysogenum • The future development trend of A. chrysogenum to meet industrial needs.
Topics: Acremonium; Anti-Bacterial Agents; Cephalosporins; Fermentation; Penicillins
PubMed: 36114850
DOI: 10.1007/s00253-022-12181-w -
Fungal Systematics and Evolution Jun 2023Three new genera, six new species, three combinations, six epitypes, and 25 interesting new host and / or geographical records are introduced in this study. New genera:...
Three new genera, six new species, three combinations, six epitypes, and 25 interesting new host and / or geographical records are introduced in this study. New genera: (based on ), and (based on ). New species: (from cooling pad water, USA, (on dead wood of sp., Netherlands), (on lichen on brick wall, Netherlands), (on moss growing on a wall, Netherlands), (from rockwool, USA), and (from hydroponic water, USA). New combinations: (based on ), (based on ), and (based on ). Epitypes: (from water, USA), (on leaves of , Netherlands), (on , parasitic on , Germany), (on needles of , Canada), (on twigs of , Ukraine), and (on decayed branch, Netherlands). Furthermore, the higher order phylogeny of three genera regarded as is resolved, namely (), (, ), and (, ), with being an older name for Crous PW, Akulov A, Balashov S, Boers J, Braun U, Castillo J, Delgado MA, Denman S, Erhard A, Gusella G, Jurjević Ž, Kruse J, Malloch DW, Osieck ER, Polizzi G, Schumacher RK, Slootweg E, Starink-Willemse M, van Iperen AL, Verkley GJM, Groenewald JZ (2023). New and Interesting Fungi. 6. : 109-156. doi: 10.3114/fuse.2023.11.09.
PubMed: 38545457
DOI: 10.3114/fuse.2023.11.09 -
Journal of Fungi (Basel, Switzerland) Jan 2022Sorbicillinoids are a family of hexaketide metabolites with a characteristic sorbyl side chain residue. Sixty-nine sorbicillinoids from fungi, newly identified from 2016... (Review)
Review
Sorbicillinoids are a family of hexaketide metabolites with a characteristic sorbyl side chain residue. Sixty-nine sorbicillinoids from fungi, newly identified from 2016 to 2021, are summarized in this review, including their structures and bioactivities. They are classified into monomeric, dimeric, trimeric, and hybrid sorbicillinoids according to their basic structural features, with the main groups comprising both monomeric and dimeric sorbicillinoids. Some of the identified sorbicillinoids have special structures such as ustilobisorbicillinol A, and sorbicillasins A and B. The majority of sorbicillinoids have been reported from fungi genera such as , , , and , with some sorbicillinoids exhibiting cytotoxic, antimicrobial, anti-inflammatory, phytotoxic, and α-glucosidase inhibitory activities. In recent years, marine-derived, extremophilic, plant endophytic, and phytopathogenic fungi have emerged as important resources for diverse sorbicillinoids with unique skeletons. The recently revealed biological activities of sorbicillinoids discovered before 2016 are also described in this review.
PubMed: 35050002
DOI: 10.3390/jof8010062 -
Structural Diversity and Biological Activities of Fungal Cyclic Peptides, Excluding Cyclodipeptides.Molecules (Basel, Switzerland) Nov 2017Cyclic peptides are cyclic compounds formed mainly by the amide bonds between either proteinogenic or non-proteinogenic amino acids. This review highlights the... (Review)
Review
Cyclic peptides are cyclic compounds formed mainly by the amide bonds between either proteinogenic or non-proteinogenic amino acids. This review highlights the occurrence, structures and biological activities of fungal cyclic peptides (excluding cyclodipeptides, and peptides containing ester bonds in the core ring) reported until August 2017. About 293 cyclic peptides belonging to the groups of cyclic tri-, tetra-, penta-, hexa-, hepta-, octa-, nona-, deca-, undeca-, dodeca-, tetradeca-, and octadecapeptides as well as cyclic peptides containing ether bonds in the core ring have been isolated from fungi. They were mainly isolated from the genera , , , and . Some of them were screened to have antimicrobial, antiviral, cytotoxic, phytotoxic, insecticidal, nematicidal, immunosuppressive and enzyme-inhibitory activities to show their potential applications. Some fungal cyclic peptides such as the echinocandins, pneumocandins and cyclosporin A have been developed as pharmaceuticals.
Topics: Amino Acids; Anti-Infective Agents; Antineoplastic Agents; Dipeptides; Drug Discovery; Fungal Proteins; Fungi; Histone Deacetylase Inhibitors; Humans; Immunosuppressive Agents; Insecticides; Peptides, Cyclic; Structure-Activity Relationship
PubMed: 29186926
DOI: 10.3390/molecules22122069