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Membranes Jan 2021In this study, a magnetic/polyetherimide-acrylonitrile composite nanofiber membrane with effective adsorption of nickel ions in an aqueous solution was created using a...
In this study, a magnetic/polyetherimide-acrylonitrile composite nanofiber membrane with effective adsorption of nickel ions in an aqueous solution was created using a simple electrospinning method. Iron oxide nanoparticles (NPs) were stirred and ultrasonically dispersed into a polyetherimide-acrylonitrile solution to create a homogenous NPs suspension, which was placed in an electrospinning machine to produce a uniform and smooth nanofiber composite membrane. Nanoparticle incorporation into this membrane was confirmed using scanning electron microscope, energy dispersive X-ray spectroscopy (EDX), Fourier-transform infrared spectroscopy (FTIR), X-ray diffraction (XRD), and NPs aqueous stability from a leaching test. The high adsorption capability of the membrane on nickel ions was attributed to the combination of magnetic NPs, polyetherimide-acrylonitrile matrix, and the nanostructure of the membrane. A membrane containing magnetic NPs demonstrated the maximum adsorption capabilities (102 mg/g) of nickel ions in an aqueous solution. Various kinetic and isotherm models were applied to understand the adsorption behavior, such as pseudo-second-order kinetic and Langmuir isotherm models. A polyetherimide-acrylonitrile composite nanofiber membrane containing magnetic NPs could be used as an environmentally friendly and nontoxic adsorbent for the removal of nickel ions in an aqueous medium due to its ease of preparation and use and stability in aqueous mediums.
PubMed: 33445745
DOI: 10.3390/membranes11010050 -
Ecotoxicology and Environmental Safety Mar 2023With styrene and acrylonitrile in ABS plastic toys as examples, this paper introduces to the development of a systematic strategy for studying the chemical migration...
With styrene and acrylonitrile in ABS plastic toys as examples, this paper introduces to the development of a systematic strategy for studying the chemical migration risk in toys. The approach, included the detection method, establishment of migration model, model verification, and the practical application of the model in risk assessment. First, simple and sensitive methods for detecting analyte residues and migration were developed by headspace GC-MS. Then, the migration models were established based on the migration data from 5 min to 168 h and verified using 11 ABS samples. The results showed that the predicted values of the models and the experimental values had a good fit (RMSE=0.10-8.72 %). Subsequently, the migration of analytes in 94 ABS toys was predicted with these models at specific migration times. The daily average exposure level to styrene and acrylonitrile were estimated for children (3 months to 3 years). At last, the migration models reasonably predicted that the cancer risk of styrene and acrylonitrile in ABS toys were 1.6 × 10-1.4 × 10 and 3.1 × 10-1.6 × 10, respectively. This research contributes to promote toy safety and child health by enriching migration models and risk assessments.
Topics: Child; Humans; Styrene; Acrylonitrile; Plastics; Butadienes; Risk Assessment
PubMed: 36706528
DOI: 10.1016/j.ecoenv.2023.114570 -
Current Organic Synthesis 2019In the synthesis of heterocyclic compounds, acrylonitrile derivatives are the most important and appropriate precursors. These compounds are the most important...
AIMS AND OBJECTIVE
In the synthesis of heterocyclic compounds, acrylonitrile derivatives are the most important and appropriate precursors. These compounds are the most important intermediates and subunits for the enhancement of molecules having pharmaceutical or biological interests. Nitrogen-containing compounds have received extensive consideration in the literature over the years.
MATERIALS AND METHODS
A facile, economic and efficient method has been developed for the synthesis of acrylonitrile derivatives using p-nitrophenylacetonitrile and aromatic/heterocyclic aldehydes in the presence of zinc chloride at room temperature. Spectroscopic data were obtained using the following instruments: Fourier transform infrared spectra (KBr discs, 4000-400 cm-1) by Shimadzu IR-408 Perkin-Elmer 1800 instrument; 1H NMR and 13C NMR spectra by Bruker Avance-II 400 MHz using DMSO-d6 as a solvent containing TMS as the internal standard.
RESULTS
To continue our ongoing studies to synthesize heterocyclic and pharmaceutical compounds by mild, facile and efficient protocols, herein we wish to report our experimental results on the synthesis of acrylonitrile derivatives, using various aromatic/heterocyclic aldehydes and p-nitrophenylacetonitrile in the presence of zinc chloride in ethanolic media at room temperature. Some of the new compounds were tested for their human serum albumin activity (HSA) while a study of interaction with HSA protein was performed for compounds 3a and 3b. The results show that compound 3b binds tightly to HSA as compared to compound 3a.
CONCLUSION
It can be concluded that acrylonitrile derivatives can be synthesized by an efficient method via the reaction of p-nitrophenylacetonitrile with aromatic/heterocyclic aldehydes by the use of zinc chloride as an effective solid catalyst. The remarkable features of this procedure include excellent yields (90-95%), short reaction period (30 min.), moderate reaction environment, easy workup procedure and managing of the catalyst. This method may find a wide significance in organic synthesis for the synthesis of the Z-acrylonitrile.
Topics: Acetonitriles; Acrylonitrile; Aldehydes; Catalysis; Chlorides; Crystallization; Humans; Protein Binding; Protein Conformation; Serum Albumin, Human; Solvents; X-Rays; Zinc Compounds
PubMed: 31984921
DOI: 10.2174/1570179416666191008085806 -
AMB Express Dec 2018Acrylonitrile (CHN) widely used in chemical raw materials has biological toxicity with -CN bond, so it is the key to removal of cyanide from acrylonitrile wastewater. In...
Acrylonitrile (CHN) widely used in chemical raw materials has biological toxicity with -CN bond, so it is the key to removal of cyanide from acrylonitrile wastewater. In our previous research and investigation, a strain was identified as Arthrobacter nitroguajacolicus named ZJUTB06-99 and was proved to be capable of degrading acrylonitrile. In this paper, the strain ZJUTB06-99 was domesticated with acrylonitrile-containing medium and its decyanidation and denitrification in simulated acrylonitrile wastewater were studied. The intermediate product of acrylonitrile in degradation process was identified through gas chromatography-mass spectrometer, as well as the biodegradation pathway of acrylonitrile in wastewater was deduced tentatively. The kinetics equation of biodegradation of acrylonitrile was lnC = - 0.1784t + 5.3349, with the degradation half-life of acrylonitrile in wastewater by 3.885 h. The results of this study showed that the optimum levels of temperature, pH and bacteria concentration to attain the maximum biodegradation were obtained as 30 °C, 6 and 100 g/L, respectively. The disadvantages of the biodegradation with this strain and its possible enhanced method to degrade acrylonitrile in wastewater were also discussed.
PubMed: 30511127
DOI: 10.1186/s13568-018-0719-8 -
Environmental Science & Technology Sep 2023The rise of electronics inevitably induced the co-pollution of novel brominated flame retardants (NBFRs) and microplastics (MPs). However, studies on how they interact...
The rise of electronics inevitably induced the co-pollution of novel brominated flame retardants (NBFRs) and microplastics (MPs). However, studies on how they interact to influence their bioavailability are scarce. Here, we explored the influence mechanism of acrylonitrile butadiene styrene (ABS)-MPs on the bioaccumulation of decabromodiphenyl ethane (DBDPE) in soil-earthworm microcosms. The influence exhibited a temporal pattern characterized by short-term inhibition and long-term promotion. After 28 days of exposure, DBDPE bioaccumulation in a co-exposure (10 mg kg DBDPE accompanied by 1000 mg kg ABS-MPs) was 2.61 times higher than that in a separate exposure. The adsorption process in the soil, intestines, and mucus introduced DBDPE-carried MPs, which had a higher concentration of DBDPE than the surrounding soil and directly affected the bioavailability of DBDPE. MP-pre-exposure (100, 1000, and 10000 mg kg) reduced epidermal soundness, mucus secretion, and worm cast production. This eventually promoted the contact between earthworm and soil particles and enhanced the DBDPE of earthworm tissue by 6%-61% in the next DBDPE-postexposure period, confirming that MPs increased DBDPE bioaccumulation indirectly by impairing the earthworm health. This study indicates that MPs promoted DBDPE bioaccumulation via adsorption and self-toxicity, providing new insight into the combined risk of MPs and NBFRs.
Topics: Animals; Bioaccumulation; Oligochaeta; Microplastics; Plastics; Acrylonitrile; Flame Retardants; Soil
PubMed: 37668438
DOI: 10.1021/acs.est.3c02915 -
Small (Weinheim An Der Bergstrasse,... Sep 2021Herein, alkoxylation chemistry is introduced as a "one-stone-three-birds" solution for exploring a new family of highly-fluorescent octupolar 2D-conjugated organic...
Herein, alkoxylation chemistry is introduced as a "one-stone-three-birds" solution for exploring a new family of highly-fluorescent octupolar 2D-conjugated organic polymers/frameworks (OCOPs/OCOFs) combining far-red emission, high fluorescence quantum yield (QY), and strong two-photon absorption (TPA). Both alkoxy-substituted OCOP and OCOF comprising acrylonitrile-bridged strongly-coupled donor3-(acceptor core) chromophores densely packed in either disordered or ordered forms, exhibit significantly redshifted emission. They produce high QY of 22.2% and 27.8% in tetrahydrofuran, large TPA cross section of 600 and 1124 GM, and 2-3 folds and 15-30 folds that of non-alkoxylate amorphous counterpart respectively. Combined theoretical and experimental studies reveal unique "one-stone-three-birds" role of the alkoxylation in realizing red-shifted-emission, improved QY and TPA enabled by inducing steric hindrance effect for weakened π-π stacking, and triggering p-π conjugation effect for electronically engineering octupolar chromophores, while the crystalline engineering enables enforced coplanarity conformation and improved π-electron delocalization for further improved QY and TPA. The robust and biocompatible pentoxy-substituted polymer can be used not only as metal-free red-emissive phosphor for efficient warm white light-emitting diodes, but also as efficient two-photon fluorescence probes for bio-imaging.
Topics: Acrylonitrile; Electrons; Photons; Polymers; Spectrometry, Fluorescence
PubMed: 34319656
DOI: 10.1002/smll.202100955 -
Molecules (Basel, Switzerland) Aug 2021Newly designed and synthesized cyano, amidino and acrylonitrile 2,5-disubstituted furane derivatives with either benzimidazole/benzothiazole nuclei have been evaluated...
Newly designed and synthesized cyano, amidino and acrylonitrile 2,5-disubstituted furane derivatives with either benzimidazole/benzothiazole nuclei have been evaluated for antitumor and antimicrobial activity. For potential antitumor activity, the compounds were tested in 2D and 3D cell culture methods on three human lung cancer cell lines, A549, HCC827 and NCI-H358, with MTS cytotoxicity and BrdU proliferation assays in vitro. Compounds , , , and have been proven to be compounds with potential antitumor activity with high potential to stop the proliferation of cells. In general, benzothiazole derivatives were more active in comparison to benzimidazole derivatives. Antimicrobial activity was evaluated with Broth microdilution testing (according to CLSI (Clinical Laboratory Standards Institute) guidelines) on Gram-negative and Gram-positive . Additionally, was included in testing as a eukaryotic model organism. Compounds , , , and showed the most promising antibacterial activity. In general, the compounds showed antitumor activity, higher in 2D assays in comparison with 3D assays, on all three cell lines in both assays. In natural conditions, compounds with such an activity profile (less toxic but still effective against tumor growth) could be promising new antitumor drugs. Some of the tested compounds showed antimicrobial activity. In contrast to ctDNA, the presence of nitro group or chlorine in selected furane-benzothiazole structures did not influence the binding mode with AT-DNA. All compounds dominantly bound inside the minor groove of AT-DNA either in form of monomers or dimer and higher-order aggregates.
Topics: Anti-Infective Agents; Antineoplastic Agents; Benzimidazoles; Benzothiazoles; Cell Line, Tumor; Cell Proliferation; Drug Screening Assays, Antitumor; Humans; Molecular Structure; Neoplasms; Staphylococcus aureus; Structure-Activity Relationship
PubMed: 34443523
DOI: 10.3390/molecules26164935 -
ACS Chemical Biology Oct 2022Nanopore direct RNA sequencing (dRNA-Seq) reads reveal RNA modifications through consistent error profiles specific to a modified nucleobase. However, a null data set is...
Nanopore direct RNA sequencing (dRNA-Seq) reads reveal RNA modifications through consistent error profiles specific to a modified nucleobase. However, a null data set is required to identify actual RNA modification-associated errors for distinguishing it from confounding highly intrinsic sequencing errors. Here, we reveal that inosine creates a signature mismatch error in dRNA-Seq reads and obviates the need for a null data set by harnessing the selective reactivity of acrylonitrile for validating the presence of actual inosine modifications. Selective reactivity of acrylonitrile toward inosine altered multiple dRNA-Seq parameters like signal intensity and trace value. We also deduced the stoichiometry of inosine modification through deviation in signal intensity and trace value using this chemical biology approach. Furthermore, we devised Nano ICE-Seq, a protocol to overcome the low coverage issue associated with direct RNA sequencing. Taken together, our chemical probe-based approach may facilitate the knockout-free detection of disease-associated RNA modifications in clinical scenarios.
Topics: Nanopore Sequencing; High-Throughput Nucleotide Sequencing; Acrylonitrile; Inosine; RNA
PubMed: 36190780
DOI: 10.1021/acschembio.2c00221 -
Journal of Medical Radiation Sciences Dec 2022This cross-sectional survey aimed to collect data from radiation therapy departments around Australia and New Zealand to establish a baseline of 3D printer and product...
INTRODUCTION
This cross-sectional survey aimed to collect data from radiation therapy departments around Australia and New Zealand to establish a baseline of 3D printer and product use.
METHODS
Each department in Australia and New Zealand was contacted to determine the most appropriate person to answer the survey. A Microsoft Forms link to the survey was sent to the individual. The survey contained 47 questions in relation to what 3D printing device departments had (if any), how it was being utilised, and what 3D printed products were in use.
RESULTS
A total of 112 departments completed the survey (100% response rate), with 22.3% reporting 3D printer ownership, and thirty-four departments (30.4%) outsourcing 3D printed products. The primary use of 3D printers was bolus production (60.9%). Public departments represented 84% of printer ownership, while private departments were the greatest users of outsourced 3D printed products (91.4%). 3D Slicer was the most common software used for Digital Imaging and Communications in Medicine (DICOM) file conversion (42.3%), while polylactic acid (PLA) and acrylonitrile butadiene styrene (ABS) were the most common filaments in use, 46% and 14%, respectively.
CONCLUSION
This research established a baseline for 3D printer and product use within the Australian and New Zealand radiotherapy setting.
Topics: Humans; Cross-Sectional Studies; New Zealand; Australia; Printing, Three-Dimensional; Acrylonitrile
PubMed: 36097141
DOI: 10.1002/jmrs.613 -
Medical Gas Research 2023Acrylonitrile is a potential carcinogen for humans, and exposure to this substance can cause adverse effects for workers. This study aimed to carcinogenic and health...
Quantitative risk assessment of respiratory exposure to acrylonitrile vapor in petrochemical industry by U.S. Environmental Protection Agency method: a cross-sectional study.
Acrylonitrile is a potential carcinogen for humans, and exposure to this substance can cause adverse effects for workers. This study aimed to carcinogenic and health risk assessment of acrylonitrile vapor exposure in exposed personnel of a petrochemical complex. This crosssectional study was performed in 2019 in a petrochemical complex. In this study, to sample and determine acrylonitrile's respiratory exposure, the method provided by the National Institute of Occupational Safety and Health (NIOSH 1601) was used, and a total of 45 inhaled air samples were sampled from men workers, aged 39.43 ± 9.37 years. All subjects' mean exposure to acrylonitrile vapors was 71.1 ± 122.8 μg/m. Also, the mean exposure index among all subjects was 0.02 ± 0.034. The non-carcinogenic risk assessment results showed that the mean Hazard quotient index was 4.04 ± 6.93. The mean lifetime cancer risk index was also 2.1 × 10 ± 3.5 × 10 and was in the definite risk range. Considering that both carcinogenicity and health indicators of exposure to acrylonitrile in the studied petrochemical complex are more than the recommended limits, the necessary engineering and management measures to control and manage the risk to an acceptable level are essential to improving the worker's health.
Topics: Male; United States; Humans; Acrylonitrile; Cross-Sectional Studies; Occupational Exposure; United States Environmental Protection Agency; Carcinogens; Risk Assessment
PubMed: 36571380
DOI: 10.4103/2045-9912.350859