-
Hormones (Athens, Greece) Mar 2023Metanephrines (MTNs) are metabolites of catecholamines and are constantly produced in high amounts by pheochromocytomas and paragangliomas (PPGLs). Marked MTN elevations...
INTRODUCTION
Metanephrines (MTNs) are metabolites of catecholamines and are constantly produced in high amounts by pheochromocytomas and paragangliomas (PPGLs). Marked MTN elevations (> 3 times the upper limit of normal [ULN]) are highly suggestive of PPGL. The frequency of marked MTN elevations in non-PPGL hypertensive emergencies (HTNEs) is unknown.
METHODS
We retrospectively analyzed plasma free metanephrine (PMTN) and 24-h urinary fractionated metanephrine (UMTN) levels in 48 consecutive patients (59.7 ± 15.6 years; 48% female; BMI: 31 ± 9.7 kg/m) hospitalized for HTNE, defined as systolic blood pressure (SBP) > 180 mmHg or diastolic blood pressure (DBP) > 120 mmHg with end-organ damage. PMTNs were measured in 47 patients, UMTNs were measured in 16 patients, and both PMTNs and UMTNs were measured in 15 patients.
RESULTS
PMTN/UMTN levels were not associated with SBP/DBP, comorbidities, end-organ damage, or interfering medications, the exception being that plasma normetanephrines (PNMNs) were significantly associated with comorbidities (Adj. R = 0.16; p = 0.04) and interfering medications (Adj. R = 0.15; p = 0.03), although with weak correlation. Marked MTN (specifically PNMN) elevations (647, 521, and 453 pg/mL; normal ≤ 148 pg/mL) were noted in only three patients (6%).
DISCUSSION
Marked MTN elevations in HTNE are uncommon. Therefore, we recommend against measuring MTN in the setting of an apparent precipitating cause of HTNE to avoid unnecessary testing and imaging. Testing for MTN in HTNE should be pursued only when there is no clear precipitating cause and in cases where there is strong underlying clinical suspicion for PPGL. However, should testing be performed, marked MTN elevations should not be disregarded as being a commonly occurring result of HTNE.
Topics: Humans; Female; Male; Metanephrine; Retrospective Studies; Pheochromocytoma; Paraganglioma; Adrenal Gland Neoplasms
PubMed: 36596928
DOI: 10.1007/s42000-022-00422-6 -
European Archives of... Jul 2017The aim of this study was to present our experiences with patients operated on for the recurrence of papillary thyroid cancer with the combined use of preoperative...
The aim of this study was to present our experiences with patients operated on for the recurrence of papillary thyroid cancer with the combined use of preoperative ultrasonographic mapping and radioguided occult lesion localization (ROLL). Twenty patients who had already undergone total thyroidectomy and central/lateral neck dissection for papillary thyroid carcinoma were reoperated on due to locoregional metastasis. The patients with proven recurrences and high Tg wash-out levels in cytopathologic aspirates were operated on. For each patient, numbers of marked and non-marked lesions, and the metastatic and total numbers of marked/non-marked and non-mentioned lesions in the maps were recorded. Thirty-four of 40 (85%) lesions removed with ROLL were found to be malignant. In addition to the marked lesions during mapping, 60 additional lesions had been defined as suspicious. Fifty-six of these lesions were found at exact anatomic sites and localizations described and removed. Of 56 lesions, 36 (64%) were found to be metastatic. During postoperative follow-up, chylous leak with spontaneous regression in 7 days and seroma occurred in one patient. Radioguided occult lesion localization and preoperative mapping contribute to the safety and comfort of patients in planned reoperations on lateral and central neck regions.
Topics: Adult; Aged; Carcinoma, Papillary; Female; Humans; Male; Middle Aged; Neck Dissection; Neoplasm Recurrence, Local; Preoperative Care; Reoperation; Surgery, Computer-Assisted; Thyroid Cancer, Papillary; Thyroid Neoplasms; Thyroidectomy; Ultrasonography
PubMed: 28409262
DOI: 10.1007/s00405-017-4563-2 -
Veterinary Medicine and Science Jul 2022Canine eosinophilia has not been evaluated over the last two decades. As in human local differences, changes in the prevalence and associated diseases over time can be...
BACKGROUND
Canine eosinophilia has not been evaluated over the last two decades. As in human local differences, changes in the prevalence and associated diseases over time can be expected.
OBJECTIVE
This study aims to determine the prevalence and causes of marked blood eosinophilia in dogs.
METHODS
Retrospective study. A total of 317 clinical histories of dogs with an eosinophil concentration > 1.5 × 10 /L (marked eosinophilia) between 2013 and 2017 were evaluated. Patients were allocated to 10 groups according to their major clinical findings.
RESULTS
Eosinophilia was present in 1,592 of 10,829 dogs (14.7%); it was mild (0.8-1.49 × 10 /L) in 78.4%, moderate (1.5 - 4.9 × 10 /L) in 20.5% and severe (> 5 × 10 /L) in 1.1% of cases. Rottweilers were overrepresented (16.1%). Of 317 cases with marked eosinophilia, 19.6% had neoplasia, 19.1% gastrointestinal disorders, 13.6% health check, 10.4% endoparasites, 6% respiratory, 5.4% neurologic, 5.4% dermatologic, 4.8% urogenital, 3.2% endocrine disorders and 12.6% miscellaneous. Lymphomas (29%) and mast cell tumours (12.9%) were the most frequent tumours in the neoplasia group. A total of 72.6% of tumour-bearing dogs were older than 8 years, while 63.6% of dogs had endoparasites, and 86% of apparently healthy dogs were younger than 5 years. Eosinophilia was significantly higher in patients with respiratory disorders (p < 0.0146). Leukocytosis was found in 50.2% of cases.
CONCLUSION
Malignancy was the most common cause of marked blood eosinophilia in older dogs and endoparasitism in younger dogs. Eosinophilia was common in apparently healthy young dogs and may be related to undiagnosed parasitic infestations.
Topics: Animals; Dog Diseases; Dogs; Ectoparasitic Infestations; Eosinophilia; Humans; Leukocyte Count; Prevalence; Retrospective Studies
PubMed: 35654102
DOI: 10.1002/vms3.832 -
Polymers Feb 2023The basic intention of the present work is to analyze the influence of the incorporated microporous membrane and the technology of the needling process on the functional...
The basic intention of the present work is to analyze the influence of the incorporated microporous membrane and the technology of the needling process on the functional properties of nonwovens designed as an insulating layer for protective gloves for protection against high temperatures. The investigated nonwovens are produced in carded nonwoven formation and mechanically bonded with needle bonding. The studied nonwovens contain a microporous membrane of polyester (PES) with a thickness of 20 µm (samples marked as ST and STL). In the theoretical part of the research work, the nonwovens and some technology stages are presented. The experimental part of the present work deals with the mechanical properties: breaking stress and strain, viscoelastic properties (yield strength, elastic modulus) and elastic recovery after cyclic loading and thermal conduction. In the experimental part, permeability properties (water vapor permeability, air permeability) are also analyzed. The results of the investigation show that the samples marked as ST and STL, which contain a microporous PES membrane, have a higher breaking stress than the samples marked as T and TL without the microporous PES membrane. Samples marked as ST and STL also exhibit higher values of elongation at break and limit of recoverable deformation (stress and strain at yield) and a lower modulus of elasticity than samples marked as T and TL. The samples marked as ST and STL are mechanically bonded to the lamellar plate using forked needles and therefore have a textured (ribbed) shape that affects the improved mechanical properties. The TL and STL samples, which contain a microporous PES membrane, have higher elastic recovery and lower air permeability than the T and TL samples, while water vapor permeability is lower only for the ST sample.
PubMed: 36772086
DOI: 10.3390/polym15030785 -
Cureus Jul 2022Remdesivir has been extensively employed during the coronavirus disease 2019 (COVID-19) pandemic as it has proven to be efficacious against the causative SARS-CoV-2....
Remdesivir has been extensively employed during the coronavirus disease 2019 (COVID-19) pandemic as it has proven to be efficacious against the causative SARS-CoV-2. However, there is not much evidence on the cardiovascular adverse effect profile of remdesivir. In addition, limited data support the occurrence of sinus bradycardia associated with remdesivir. Herein we chronicle a clinical encounter of a patient suffering from COVID-19 whose clinical course was complicated by marked sinus bradycardia that began acutely after remdesivir initiation and resolved on cessation of the medication. The patient denied symptoms and completed a 5-day course with a resolution of bradycardia on completion of medication. We suggest that the physicians be cognizant of this rare side effect of remdesivir and suggest a continuation of this medication unless symptomatic bradycardia precludes management.
PubMed: 36035063
DOI: 10.7759/cureus.27249 -
Acta Neurologica Scandinavica Dec 2018Studies on long-term progression of white matter hyperintensities (WMH) after ischemic stroke are scarce. Here, we sought to investigate this progression and its...
OBJECTIVES
Studies on long-term progression of white matter hyperintensities (WMH) after ischemic stroke are scarce. Here, we sought to investigate this progression and its predictors in a cohort presenting with ischemic stroke before 70 years of age.
MATERIALS AND METHODS
Participants in the Sahlgrenska Academy Study on Ischemic Stroke who underwent magnetic resonance imaging (MRI) of the brain at index stroke were examined by MRI again after 7 years (n = 188, mean age 53 years at index stroke, 35% females). WMH at index stroke and progression were assessed according to Fazekas' grades and the WMH change scale. Stroke subtype was classified according to TOAST.
RESULTS
Marked WMH at index stroke were present in 20% of the participants and were significantly associated with age, hypertension, and subtype. Progression of WMH after 7 years was observed in 63% and 35% of the participants for subcortical and periventricular locations, respectively. Significant independent predictors of progression were age and marked WMH at baseline for both locations, whereas no significant associations were detected for vascular risk factors or subtype in multivariable analyses. In participants with no or only mild WMH at baseline, 20% showed marked WMH at follow-up. Age and hypertension, but not subtype, were independently associated with this acquisition of marked WMH.
CONCLUSIONS
Age and marked WMH at index stroke, but not stroke subtype, predicted long-term WMH progression after ischemic stroke before 70 years of age, whereas age and hypertension predicted acquisition of marked WMH in those with no or only mild WMH at baseline.
Topics: Aged; Brain Ischemia; Cohort Studies; Disease Progression; Female; Humans; Magnetic Resonance Imaging; Male; Middle Aged; Risk Factors; Stroke; Time; White Matter
PubMed: 30152523
DOI: 10.1111/ane.13019 -
Cultural Diversity & Ethnic Minority... Nov 2023The present study identified unique profiles of cultural stressors (i.e., bicultural stress, discrimination, and negative context of reception) and acculturative...
OBJECTIVE
The present study identified unique profiles of cultural stressors (i.e., bicultural stress, discrimination, and negative context of reception) and acculturative strategies (i.e., heritage practices, heritage identification, U.S. practices, and U.S. identification), in Hispanic/Latinx (HL) emerging adults. Additionally, we examined associations between positive and negative psychosocial functioning, with profiles of acculturative strategies and cultural stressors.
METHOD
The present study utilized a baseline sample of 779 HL college students (75.8% female, = 20.80 years, = 2.66) drawn from a daily diary study on acculturation.
RESULTS
Latent profile analysis identified four distinct profiles. The Bicultural and Low Cultural Stressors (B-LowCS; 53.55%) was marked by strong heritage and U.S. cultural orientation and low levels across all cultural stressors. The Marginalization and High Acculturative Stressors (M-HighAS; 20.13%) was marked by weak heritage and U.S. cultural orientation, high acculturative stressors, and low discrimination. The third profile, the Heritage Rejection and Low Cultural Stressors (HR-LowCS; 16.05%) was marked by rejection of heritage culture and low cultural stressors. Finally, the Separation and High Cultural Stressors (S-HighCS; 10.26%) was marked by weak U.S. cultural orientation and high cultural stressors. Consistent with past research, the B-LowCS profile was marked by the highest level of positive psychosocial functioning and the lowest levels of internalizing and externalizing symptoms.
CONCLUSIONS
The results of the present study highlight the usefulness of person-centered approaches for understanding the interplay between acculturative strategies and cultural stressors, and the implications of these distinct profiles on psychosocial functioning in HL emerging adults. (PsycInfo Database Record (c) 2024 APA, all rights reserved).
PubMed: 37917482
DOI: 10.1037/cdp0000625 -
EcoHealth Dec 2022Flies form high-density associations with human settlements and groups of nonhuman primates and are implicated in transmitting pathogens. We investigate the movement of...
Flies form high-density associations with human settlements and groups of nonhuman primates and are implicated in transmitting pathogens. We investigate the movement of nonhuman primate-associated flies across landscapes surrounding Kibale National Park, Uganda, using a mark-recapture experiment. Flies were marked in nine nonhuman primate groups at the forest edge ([Formula: see text] = 929 flies per group), and we then attempted to recapture them in more anthropized areas (50 m, 200 m and 500 m from where marked; 2-21 days after marking). Flies marked in nonhuman primate groups were recaptured in human areas (19/28,615 recaptured). Metabarcoding of the flies in nonhuman primate groups revealed the DNA of multiple eukaryotic primate parasites. Taken together, these results demonstrate the potential of flies to serve as vectors between nonhuman primates, livestock and humans at this biodiverse interface.
Topics: Humans; Animals; Animals, Wild; Diptera; Primates; Livestock; DNA
PubMed: 36629957
DOI: 10.1007/s10393-022-01621-8 -
Forensic Sciences Research 2022Hallucinogenic mushroom is a kind of toxic strain containing psychoactive tryptamine substances such as psilocybin, psilocin and ibotenic acid, etc. The mushrooms...
Hallucinogenic mushroom is a kind of toxic strain containing psychoactive tryptamine substances such as psilocybin, psilocin and ibotenic acid, etc. The mushrooms containing hallucinogenic components are various, widely distributed and lack of standard to define, which made a great challenge to identification. Traditional identification methods, such as morphology and toxicology analysis, showed shortcomings in old or processed samples, while the DNA-based identification of hallucinogenic mushrooms would allow to identify these samples due to the stability of DNA. In this paper, four primer sets are designed to target DNA for increasing resolution of present identification method, and the target markers include largest subunit of RNA polymerase II (marked as PC-R1), psilocybin-related phosphotransferase gene (marked as PC-PT), glyceraldehyde 3-phosphate dehydrogenase (marked as PC-3) and translation EF1α (marked as PC-EF). Real-time PCR with high-resolution melting (HRM) assay were used for the differentiation of the fragments amplified by these primer sets, which were tested for specificity, reproducibility, sensitivity, mixture analysis and multiplex PCR. It was shown that the melting temperatures of PC-R1, PC-PT, PC-3 and PC-EF of were (87.93 ± 0.12) °C, (82.21 ± 0.14) °C, (79.72 ± 0.12) °C and (80.11 ± 0.19) °C in our kinds of independent experiments. Significant HRM characteristic can be shown with a low concentration of 62.5 pg/µL DNA sample, and could be detected in mixtures with or . In summary, the method of HRM analysis can quickly and specifically distinguish from other species, which could be utilized for forensic science, medical diagnosis and drug trafficking cases. Supplemental data for this article are available online at https://doi.org/10.1080/20961790.2021.1875580.
PubMed: 36353314
DOI: 10.1080/20961790.2021.1875580 -
Journal of the History of the... 2017An acerbic footnote in Volume 3 (1818) of the five-volume great work of Franz Joseph Gall and Johann Gaspar Spurzheim, Anatomy and Physiology of the Nervous System in...
An acerbic footnote in Volume 3 (1818) of the five-volume great work of Franz Joseph Gall and Johann Gaspar Spurzheim, Anatomy and Physiology of the Nervous System in General and of the Brain in Particular with Observations on the Possibility of Understanding the Many Moral and Intellectual Dispositions of Man and Animals by the Configuration of Their Heads, marked the end of the collaboration between Gall, the founder of organologie, and Spurzheim, promoter of phrenology. We discuss the background of this note and the nature of the rift that marked the end of Gall and Spurzheim's collaboration.
Topics: Brain; Conflict, Psychological; History, 18th Century; History, 19th Century; Humans; Mentors; Neurosciences; Phrenology
PubMed: 27767377
DOI: 10.1080/0964704X.2016.1204807