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Acupuncture for neurogenesis in experimental ischemic stroke: a systematic review and meta-analysis.Scientific Reports Jan 2016Acupuncture has been used for patients with stroke and post-stroke rehabilitation for thousands of years. Previous studies reported that acupuncture enhanced stroke... (Meta-Analysis)
Meta-Analysis Review
Acupuncture has been used for patients with stroke and post-stroke rehabilitation for thousands of years. Previous studies reported that acupuncture enhanced stroke recovery through neurogenesis. Hence, we conducted a systematic review and meta-analysis for preclinical studies to assess the current evidence for acupuncture effect on neurogenesis in treating ischaemic stroke. Studies were obtained from six databases, including PubMed, EMBASE, Cochrane Library, Chinese National Knowledge Infrastructure, VIP information database, and Chinese Biomedical Literature Database, Ultimately, 34 studies containing 1617 animals were identified. Neurogenesis markers of Brdu, Nestin, PSA-NCAM, NeuN and GFAP were selected as major outcomes. The pooled results of 15 studies marked with Brdu showed significant effects of acupuncture for improving proliferation when compared with control groups (P < 0.01); 13 studies marked with Nestin showed significant effects of acupuncture for increasing proliferation when compared with control groups (P < 0.01); 4 studies marked with PSA-NCAM showed significant effects of acupuncture for enhancing migration when compared with control groups (P < 0.01); 4 studies marked with NeuN showed significant effects of acupuncture for stimulating differentiation when compared with control groups (P < 0.01). The findings suggest that acupuncture is a prospective therapy targeting neurogenesis for ischemic stroke.
Topics: Acupuncture; Acupuncture Therapy; Animals; Biomarkers; Brain; Cell Differentiation; Cell Movement; Cell Proliferation; Disease Models, Animal; Humans; Neurogenesis; Publication Bias; Stroke; Treatment Outcome
PubMed: 26786869
DOI: 10.1038/srep19521 -
Brazilian Journal of Physical Therapy 2021Executive dysfunction and risk of falling are hallmarks of Parkinson's disease (PD). However, it is unclear how executive dysfunction predisposes people with PD to...
BACKGROUND
Executive dysfunction and risk of falling are hallmarks of Parkinson's disease (PD). However, it is unclear how executive dysfunction predisposes people with PD to falling.
OBJECTIVES
To: (i) identify sensorimotor, balance, and cardiovascular risk factors for falls that discriminate between those with normal executive function and those with mild and marked executive dysfunction in people with PD and (ii) determine whether mild and marked executive dysfunction are significant risk factors for falls when adjusting for PD duration and severity and freezing of gait (FOG).
METHODS
Using the Frontal Assessment Battery, 243 participants were classified into normal executive function (n = 87), mild executive dysfunction (n = 100), and marked executive dysfunction (n = 56) groups. Participants were asked if they had episodes of FOG in the last month and were assessed with the Movement Disorders Society - Unified Parkinson's Disease Rating Scale (MDS-UPDRS), the Hoehn and Yahr Scale, the physiological profile assessment, and tests of orthostatic hypotension, coordinated stability, and gait and were then followed-up prospectively for falls for 32-52 weeks.
RESULTS
Several PD-specific (elevated Hoehn and Yahr stage, higher MDS-UPDRS scale scores, a history of FOG, Postural Instability and Gait Difficulty subtype, and longer PD duration), sensorimotor (poor vision, knee extension weakness, slow simple reaction time), and balance (greater postural sway and poor controlled leaning balance) factors discriminated among the normal executive function and mild and marked executive dysfunction groups. Fall rates (mean ± SD) differed significantly among the groups (normal executive function: 1.0 ± 1.7; mild executive dysfunction: 2.8 ± 5.2; marked executive dysfunction: 4.7 ± 7.3) with the presence of both mild and marked executive dysfunction identified as significant risk factors for falls when adjusting for three measures of PD severity (Hoehn and Yahr scale scores, disease duration, and FOG).
CONCLUSIONS
Several PD-specific, sensorimotor, and balance factors differed significantly among the normal, mild, and marked executive dysfunction groups and both mild and marked executive dysfunction were identified as independent risk factors for falls in people with PD.
Topics: Cognitive Dysfunction; Executive Function; Gait Disorders, Neurologic; Humans; Parkinson Disease; Postural Balance; Risk Factors; Severity of Illness Index
PubMed: 33349526
DOI: 10.1016/j.bjpt.2020.11.005 -
Scientific Reports Aug 2023Automated text recognition techniques have made significant advancements; however, certain tasks still present challenges. This study is motivated by the need to...
Automated text recognition techniques have made significant advancements; however, certain tasks still present challenges. This study is motivated by the need to automatically recognize hand-marked text on construction defect tags among millions of photographs. To address this challenge, we investigated three methods for automating hand-marked semantic text recognition (HMSTR)-a modified scene text recognition-based (STR) approach, a two-step HMSTR approach, and a lumped approach. The STR approach involves locating marked text using an object detection model and recognizing it using a competition-winning STR model. Similarly, the two-step HMSTR approach first localizes the marked text and then recognizes the semantic text using an image classification model. By contrast, the lumped approach performs both localization and identification of marked semantic text in a single step using object detection. Among these approaches, the two-step HMSTR approach achieved the highest F1 score (0.92) for recognizing circled text, followed by the STR approach (0.87) and the lumped approach (0.78). To validate the generalizability of the two-step HMSTR approach, subsequent experiments were conducted using check-marked text, resulting in an F1 score of 0.88. Although the proposed methods have been tested specifically with tags, they can be extended to recognize marked text in reports or books.
PubMed: 37648714
DOI: 10.1038/s41598-023-41489-4 -
Annals of Combinatorics 2022In this paper, we expand on the notion of , first introduced explicitly by Aguiar and Mahajan in 2010 but already present in the literature in some other points of view....
In this paper, we expand on the notion of , first introduced explicitly by Aguiar and Mahajan in 2010 but already present in the literature in some other points of view. We do this by adapting the algebraic framework of species to the study of substructures in combinatorics. Afterwards, we consider functions that count the number of patterns of objects and endow the linear span of these functions with a product and a coproduct. In this way, any well-behaved family of combinatorial objects that admits a notion of substructure generates a Hopf algebra, and this association is functorial. For example, the Hopf algebra on permutations studied by Vargas in 2014 and the Hopf algebra on symmetric functions are particular cases of this construction. A specific family of pattern Hopf algebras of interest are the ones arising from . This includes the presheaves on graphs, posets and generalized permutahedra. Here, we show that all the pattern Hopf algebras corresponding to commutative presheaves are free. We also study a remarkable non-commutative presheaf structure on marked permutations, permutations with a marked element. These objects have a natural product called inflation, which is an operation motivated by factorization theorems for permutations. In this paper, we find new factorization theorems for marked permutations. We use these theorems to show that the pattern Hopf algebra for marked permutations is also free, using Lyndon words techniques.
PubMed: 35782409
DOI: 10.1007/s00026-022-00578-3 -
Pain Management May 2022Better documentation of vulvar pain is needed. We examined pain locations marked on general body and genital specific outlines among women with vulvodynia. 62 women...
Better documentation of vulvar pain is needed. We examined pain locations marked on general body and genital specific outlines among women with vulvodynia. 62 women (mean age 32.1 ± 9.5 years) with vulvodynia marked their pain on a digital genital specific outline (22 segments) and 59 of those women also marked their pain on a digital general body outline (48 segments). We used ImageJ software to determine body surface area (BSA) for each outline. On the general body outline, 24/48 segments were marked; 22/22 segments were marked on the genital specific outline. There was a moderate correlation ( = 0.43; p = 0.001) between the BSA marked on the general body outline and the BSA marked on the genital area outline. Findings support concurrent validity of the BSA as a measure of pain location using either outline.
Topics: Adult; Documentation; Female; Humans; Pain; Vulvodynia; Young Adult
PubMed: 35060761
DOI: 10.2217/pmt-2021-0110 -
Neuropsychobiology 2014The aims of the present study were to explore whether symptoms in different anxiety disorders are associated with Cloninger's model temperament dimensions novelty... (Meta-Analysis)
Meta-Analysis Review
BACKGROUND
The aims of the present study were to explore whether symptoms in different anxiety disorders are associated with Cloninger's model temperament dimensions novelty seeking (NS), harm avoidance (HA), reward dependence and persistence compared with control subjects in clinical samples of adults or late adolescents.
METHOD
Literature search in the following databases: Cochrane Library, PubMed (Medline), Web of Science, Psycinfo and PsycArticles. Systematic review, grading the level of evidence and meta-analysis for each disorder by comparing the temperament dimension scores between patient and control samples in single studies.
RESULTS
A total of 40 papers fulfilled the inclusion criteria. Meta-analyses were conducted on a total of 24 studies focusing on panic disorder (PD), social anxiety disorder (SAD) and obsessive-compulsive disorder (OCD). The primary finding was a constant and clinically marked positive association between the HA temperament dimension and symptoms of PD, SAD and OCD, with a most marked effect in SAD, and a moderate effect in OCD and PD. Second, less marked and clinically marginal associations between NS score and SAD and OCD (negative associations), but no associations with PD were observed. The meta-analyses revealed heterogeneity between the results of individual studies, especially in the analyses including SAD and OCD.
CONCLUSIONS
PD, SAD and OCD share a marked and state-dependent avoidant behavioral pattern, which is common for all anxiety disorders. However, PD showed a different pattern of arousal to novel stimuli from that of SAD and OCD. The findings are state dependent and based on cross-sectional studies.
Topics: Humans; Obsessive-Compulsive Disorder; Panic Disorder; Personality Inventory; Phobic Disorders; Stress Disorders, Post-Traumatic; Temperament
PubMed: 24852727
DOI: 10.1159/000360738 -
Neurology India Sep 2005Protein aggregate myopathies (PAM) are an emerging group of muscle diseases characterized by structural abnormalities. Protein aggregate myopathies are marked by the... (Review)
Review
Protein aggregate myopathies (PAM) are an emerging group of muscle diseases characterized by structural abnormalities. Protein aggregate myopathies are marked by the aggregation of intrinsic proteins within muscle fibers and fall into four major groups or conditions: (1) desmin-related myopathies (DRM) that include desminopathies, a-B crystallinopathies, selenoproteinopathies caused by mutations in the, a-B crystallin and selenoprotein N1 genes, (2) hereditary inclusion body myopathies, several of which have been linked to different chromosomal gene loci, but with as yet unidentified protein product, (3) actinopathies marked by mutations in the sarcomeric ACTA1 gene, and (4) myosinopathy marked by a mutation in the MYH-7 gene. While PAM forms 1 and 2 are probably based on impaired extralysosomal protein degradation, resulting in the accumulation of numerous and diverse proteins (in familial types in addition to respective mutant proteins), PAM forms 3 and 4 may represent anabolic or developmental defects because of preservation of sarcomeres outside of the actin and myosin aggregates and dearth or absence of other proteins in these actin or myosin aggregates, respectively. The pathogenetic principles governing protein aggregation within muscle fibers and subsequent structural sarcomeres are still largely unknown in both the putative catabolic and anabolic forms of PAM. Presence of inclusions and their protein composition in other congenital myopathies such as reducing bodies, cylindrical spirals, tubular aggregates and others await clarification. The hitherto described PAMs were first identified by immunohistochemistry of proteins and subsequently by molecular analysis of their genes.
Topics: Actins; Chromosome Mapping; Desmin; Humans; Mutation; Myopathies, Structural, Congenital; Proteins
PubMed: 16230791
DOI: 10.4103/0028-3886.16921 -
Molecular Genetics and Metabolism... 2014Marked hyperalphalipoproteinemia (HAL) is a heterogeneous syndrome. To clarify the pathophysiological significance of HAL, we compared clinical profiles between marked...
Marked hyperalphalipoproteinemia (HAL) is a heterogeneous syndrome. To clarify the pathophysiological significance of HAL, we compared clinical profiles between marked HAL subjects with and without cholesteryl ester transfer protein (CETP) deficiency. CETP deficiency was associated with cardiovascular diseases and strokes in the HAL population, particularly in female. HAL women without CETP deficiency tended to have higher prevalence with cancer history. HAL may not always be a longevity marker, but be sometimes accompanied with pathological conditions.
PubMed: 27896098
DOI: 10.1016/j.ymgmr.2014.06.001 -
Plastic and Reconstructive Surgery.... Sep 2022Transposition flaps are useful for reconstruction of many skin defects. Limberg described a rhomboid rotation flap in 1946. Dufourmentel described an improved version of...
Transposition flaps are useful for reconstruction of many skin defects. Limberg described a rhomboid rotation flap in 1946. Dufourmentel described an improved version of the Limberg flap in 1962. The Dufourmentel flap is also a quadrangular rhomboid flap which can be used in any area of the body except for the central face, the fingers, and the volar hand. The design of the Dufourmentel flap creates a wider base for this random flap, thus making it more reliable. Where tissue loss is significant, or where skin and soft tissue elasticity is limited, double opposing Dufourmentel flaps are useful. A variation of the Dufourmentel flap is described where a circular defect is converted to a square. The line of greatest extensibility is marked through the circular defect or lesion. A square is marked around the circle with one corner of the square tilted 10-20 degrees counterclockwise from the line of greatest extensibility. After marking corners A, B, C, and D, lines are marked extending BD and CD. The first incision, DE, will bisect the angle created by extending BD and CD. The second incision, EF, is roughly perpendicular to CD extended, but the angle at E is opened up a bit to create a wider base for the flap. Point D will rotate to point B, E rotates to C, and F translates to D. The invisible line DF should be approximately parallel to the line of greatest extensibility. When the defect is relatively large or where the surrounding tissues have limited elasticity, the above-described ideal variation of the Dufourmentel flap may not be possible because the flap may not rotate and advance all the way around without tension. In this case, double opposing Dufourmentel type flaps have been found to be useful by meeting each other at the halfway point.
PubMed: 36148032
DOI: 10.1097/GOX.0000000000004183