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Veterinary Radiology & Ultrasound : the... Jul 2023Knowledge of lagomorph confluence sinuum anatomy on contrast-enhanced CT may prevent the misdiagnoses of intracranial, extra-axial masses. The purpose of this... (Observational Study)
Observational Study
Knowledge of lagomorph confluence sinuum anatomy on contrast-enhanced CT may prevent the misdiagnoses of intracranial, extra-axial masses. The purpose of this retrospective, observational, descriptive study was to describe the characteristics of the confluence sinuum in rabbits on contrast-enhanced CT. Images of 24 rabbits who had pre- and postcontrast CT sequences of the skull were reviewed by an American College of Veterinary Radiology-certified veterinary radiologist and third-year radiology resident. Degree of contrast enhancement within the region of the confluence sinuum was graded based on consensus as no (0), mild (1), moderate (2), or marked (3) contrast enhancement. Hounsfield units (HU) of the confluence sinuum was measured in three different regions of interest, averaged for each patient, and divided into each group for comparison using one-way ANOVA analysis. Contrast enhancement was mild in 45.8% (11/24) rabbits, moderate in 33.3% (8/24), marked in 20.8% (5/24), and none in 0.0% (0/24). There were significant differences (P < 0.05) between the average HU of the mild and marked group (P-value = 0.0001) and moderate and marked groups (P-value = 0.0010). Two rabbits with marked contrast enhancement were initially misdiagnosed with an intracranial, extra-axial mass along the parietal lobe based on contrast-enhanced CT. On necropsy, no gross or histopathological abnormalities were identified in the brain for these rabbits. In summary, contrast enhancement was identified in all rabbits (24/24) on contrast-enhanced CT imaging . This normal structure can be variable in size should not be mistaken for a pathological lesion in the absence of mass effect, secondary calvarial lysis, or hyperostosis.
Topics: Rabbits; Animals; Tomography, X-Ray Computed; Contrast Media; Lagomorpha; Retrospective Studies
PubMed: 37133973
DOI: 10.1111/vru.13243 -
Digestive Diseases and Sciences Jul 2023Among liver injury causes, few result in marked elevation of liver enzymes to a level > 1,000 international units per liter (IU/L). This review summarizes common... (Meta-Analysis)
Meta-Analysis Review
BACKGROUND
Among liver injury causes, few result in marked elevation of liver enzymes to a level > 1,000 international units per liter (IU/L). This review summarizes common etiologies of marked transaminase elevation and associated prognostic factors.
METHODS
We performed a comprehensive search on PubMed, EMBASE, Cochrane Library, and Google Scholar from inception through December 2022 using MOOSE guidelines for studies reporting frequency of etiologies of marked transaminase elevation. We used a proportion meta-analysis to pool frequencies with corresponding 95% confidence interval (CI). I was used to adjudicate heterogeneity. We used CMA software for statistical analysis.
RESULTS
Seven relevant studies (n = 1608 patients) were included. The pooled frequency of ischemic hepatitis was 51% (95% CI 42-60%, I = 91%), viral hepatitis was 13.1% (95% CI 9.7-17.6%, I = 80%), toxins or drug-induced liver injury (DILI) was 13% (95% CI 8-18%, I = 85%), and pancreaticobiliary-related injury was 7.8% (95% CI 4.4-13.6%, I = 89%). Mortality was significantly higher in ischemic hepatitis versus other causes of marked transaminase elevation, with an odds ratio of 21 (95% CI 9.9-44.8, P value < 0.0001, I = 64% Q 11.1).
DISCUSSION
This is the first meta-analysis to examine etiologies of marked transaminase elevation > 1000 IU/L. Liver ischemia is the most common cause, while other causes include DILI or toxins, viral hepatitis, and biliary pathologies. We found biliary pathologies to be the fourth most common cause. This is clinically relevant as it has been traditionally linked to a cholestatic pattern of liver injury. Being aware of this presentation may help prevent delayed or missed diagnoses and unnecessary testing.
Topics: Humans; Alanine Transaminase; Liver Diseases; Cholestasis; Chemical and Drug Induced Liver Injury; Hepatitis, Viral, Human; Aspartate Aminotransferases
PubMed: 37184617
DOI: 10.1007/s10620-023-07962-w -
Sexuality Research & Social Policy :... Mar 2022Research has documented multiple levels of influences on adolescent sexual behavior, but has generally focused less on the relational nature of this behavior. Studies...
BACKGROUND
Research has documented multiple levels of influences on adolescent sexual behavior, but has generally focused less on the relational nature of this behavior. Studies with dyadic data have provided important findings on relationship process, including the role of gender in different-sex dyads. However, both of these bodies of literature typically utilize a variable-centered approach, which examines average influences of particular variables on sexual behavior. This study expands upon this research by presenting a dyad-centered approach to adolescent sexual behavior that can identify types of couples based on patterns of multidimensional risk and protective factors.
METHODS
I demonstrate the dyad-centered approach using data from different-sex dyads in the National Longitudinal Study of Adolescent to Adult Health to uncover profiles marked by individual, parent, peer, and religion predictors for both male and female partners.
RESULTS
Analyses uncovered five classes of dyadic influences, four of which were marked by relative similarity between partners and one marked by lesser approval of sex for women compared to men. Dyads marked by both partners intending to have sex and being in a context that is more approving of sex were more likely to engage in sexual intercourse.
CONCLUSIONS
Findings demonstrate the heterogeneity of influences and intentions to have sex among adolescent couples, and identify profiles of dyads who are more likely to engage in sexual intercourse. This approach can explicate dyadic processes involved in sexual behavior and the types of couples that exist in a population, leading to more tailored and efficacious interventions.
PubMed: 35990880
DOI: 10.1007/s13178-020-00528-9 -
Frontiers in Pharmacology 2021Hepatic ischemia-reperfusion (HIR) induces remote organs injury, including the brain. The homeostasis of the brain is maintained by the blood-brain barrier (BBB); thus,...
Hepatic ischemia-reperfusion (HIR) induces remote organs injury, including the brain. The homeostasis of the brain is maintained by the blood-brain barrier (BBB); thus, we aimed to investigate whether HIR impaired BBB and attempted to elucidate its underlying mechanism. Cell viability of human cerebral microvascular endothelial cells (hCMEC/D3) was measured following 24 h incubation with a serum of HIR rat undergoing 1 h ischemia and 4 h reperfusion, liver homogenate, or lysate of primary hepatocytes of the rat. The liver homogenate was precipitated using (NH)SO followed by separation on three columns and electrophoresis to identify the toxic molecule. Cell activity, apoptosis, proliferation, cell cycle, and expressions of proteins related to cell cycle were measured in hCMEC/D3 cells incubated with identified toxic molecules. HIR rats undergoing 1 h ischemia and 24 h reperfusion were developed to determine the release of an identified toxic molecule. BBB function was indexed as permeability to fluorescein and brain water. Endothelial cell proliferation and expressions of proteins related to the cell cycle in cerebral microvessels were measured by immunofluorescence and western blot. Toxic molecule to BBB in the liver was identified to be arginase. Arginase inhibitor nor-NOHA efficiently attenuated hCMEC/D3 damage caused by liver homogenate and serum of HIR rats. Both arginase and serum of HIR rats significantly lowered arginine (Arg) in the culture medium. Arg addition efficiently attenuated the impairment of hCMEC/D3 caused by arginase or Arg deficiency, demonstrating that arginase impaired hCMEC/D3 depriving Arg. Both arginase and Arg deficiency damaged hCMEC/D3 cells by inhibiting cell proliferation, retarding the cell cycle to G1 phase, and downregulating expressions of cyclin A, cyclin D, CDK2, and CDK4. HIR notably increased plasma arginase activity and lowered Arg level, increased the BBB permeability accompanied with enhanced brain water, and decreased the proliferative cells (marked by Ki67) in cerebral microvessels (marked by CD31) and protein expressions of cyclin A, cyclin D, CDK2 and CDK4 in isolated brain microvessels. Oral supplement of Arg remarkably attenuated these HIR-induced alterations. HIR leads to substantial release of arginase from the injured liver and then deprives systemic Arg. The Arg deficiency further impairs BBB inhibiting the proliferation of brain microvascular endothelial cells by cell cycle arrest.
PubMed: 34721021
DOI: 10.3389/fphar.2021.724471 -
International Journal of Cancer Jun 2015Cutaneous melanomas are postulated to arise through at least two causal pathways, namely the "chronic sun exposure" and "nevus" pathways. While chronic sun exposure...
Cutaneous melanomas are postulated to arise through at least two causal pathways, namely the "chronic sun exposure" and "nevus" pathways. While chronic sun exposure probably causes many head/neck melanomas, its role at other sites is unclear. In a population-based, case-case comparison study conducted in Brisbane, Australia, we determined the prevalence and epidemiologic correlates of chronic solar damage in skin adjacent to invasive, incident melanomas on the trunk (n = 418) or head/neck (n = 92) among patients aged 18-79 in 2007-2010. Participants self-reported information about environmental and phenotypic factors, and a dermatologist counted nevi and actinic keratoses. Dermatopathologists assessed solar elastosis adjacent to each melanoma using a four-point scale (nil, mild, moderate, marked), and noted the presence or absence of adjacent neval remnants. We measured associations between various factors and solar elastosis using polytomous logistic regression. Marked or moderate solar elastosis was observed in 10% and 27%, respectively, of trunk melanomas, and 60% and 17%, respectively, of head/neck melanomas. At both sites, marked elastosis was positively associated with age (p(trend) < 0.0001) and inversely associated with neval remnants (p(trend) < 0.001). For trunk melanomas, marked elastosis was associated with highest quartiles of total sun exposure [odds-ratio (OR) = 5.47, 95% confidence interval (CI) = 1.08-27.60] and facial freckling (OR = 2.98, 95% CI = 1.17-7.56), and inversely associated with deeply tanning skin (OR = 0.29, 95% CI = 0.08-1.11) and high nevus counts (OR = 0.08, 95% CI = 0.01-0.66). Mostly similar associations were observed with moderate solar elastosis. About one in three trunk melanomas in Queensland have evidence of moderate-to-marked sun damage, and they differ in risk associations from those without.
Topics: Adolescent; Adult; Aged; Australia; Dermatology; Face; Female; Humans; Logistic Models; Male; Melanoma; Middle Aged; Neck; Nevus; Nevus, Pigmented; Severity of Illness Index; Skin; Skin Diseases; Skin Neoplasms; Sunlight; Young Adult; Melanoma, Cutaneous Malignant
PubMed: 25403328
DOI: 10.1002/ijc.29335 -
Veterinary Clinical Pathology Dec 2022A 7-year-old mixed-breed neutered male cat was presented with a history of chronic vomiting with increased frequency in the last month, progressing to depression and...
A 7-year-old mixed-breed neutered male cat was presented with a history of chronic vomiting with increased frequency in the last month, progressing to depression and profuse projectile vomiting. Abdominal ultrasonography revealed an area of marked segmental duodenal thickening associated with a nodule, and euthanasia was performed due to a poor prognosis. Grossly, at the postmortem examination, the wall of a duodenal segment was severely expanded by a nodule measuring 5.0 cm in diameter, resulting in marked luminal narrowing and obstruction. Smears were made by scraping the cut surface of the tumor during the postmortem examination. The smears were highly cellular and contained mesenchymal cells arranged individually or in large non-cohesive aggregates. Cells varied in morphology from spindle to round to stellate-shaped with marked anisocytosis and anisokaryosis. Numerous bi- and multinucleated neoplastic cells were observed. Histologic examination revealed a densely cellular neoplastic proliferation of mesenchymal cells that effaced the duodenal submucosa, muscularis externa, and serosa layers. Most cells were spindle-shaped; however, some tumor areas had numerous round cells and bi- and multinucleated neoplastic cells. Spindle cells showed variable cytoplasmic immunoreactivity for vimentin, smooth muscle actin, and desmin. Round, bi-, and multinucleated giant cells only had marked multifocal cytoplasmic immunoreactivity for vimentin. Neoplastic cells did not have immunoreactivity for cytokeratin, GFAP, S100, and CD117. A final diagnosis of duodenal leiomyosarcoma was made. This article reports the pathologic, cytologic, and immunohistochemical findings of this case and discusses the main differential diagnoses in cases of intestinal sarcomas in domestic animals.
Topics: Cats; Male; Animals; Leiomyosarcoma; Vimentin; Sarcoma; Diagnosis, Differential; Vomiting; Cat Diseases
PubMed: 35466406
DOI: 10.1111/vcp.13124 -
MethodsX 2021We designed a marking stand for the Dermojet , which substantially improves fish marking via needleless subcutaneous injection of dye. The marking stand allows to...
We designed a marking stand for the Dermojet , which substantially improves fish marking via needleless subcutaneous injection of dye. The marking stand allows to increase the nozzle-to-fish distance, adjust this position and to keep the jet injector fixed during operation as well as dye refilling. A laser pointer enables a precise and small-scale aiming. Using this marking stand we marked the caudal fin of small fish with Alcian blue for a flume experiment. In total we marked 204 gudgeon () and spirlin () of 9-14 cm length with up to two dots per fish. Weighing, measuring and marking one sedated fish took 30 to 60 s. Immediate marking success was 100%. Fish were kept indoors in tanks for 7-12 days post-marking and the colour mark remained visible for the complete study period. During our flume experiment the colour marks at the caudal fin were detectable on all fish regardless of swimming position. With this easy and fast method fish can be marked gently, reliably and efficiently.•Application of a high-pressure jet injector for needleless and accurate colour marking of fish.•Manual for marking the caudal fin of small fish with Alcian blue.
PubMed: 34754781
DOI: 10.1016/j.mex.2021.101510 -
Sensors (Basel, Switzerland) Jul 2023When forming the radar situation of a terrain, in order to increase its information content and to extract useful information, multi-position spatially distributed...
When forming the radar situation of a terrain, in order to increase its information content and to extract useful information, multi-position spatially distributed systems for integrating multi-angle radar data established by small-sized UAV-based airborne radars are used. In this case, each radar station belonging to a multi-position system as a probing signal must have its own unique marked signal. Such a setup will allow the signals reflected from ground objects and zones to be "attached" to specific receiving-transmitting positions of the multi-position system. This requirement results from the fact that each transceiver position emits one probing signal, and then receives all the echo signals reflected from the underlying surface and previously emitted by other radar devices of the multi-position system. Such a setup of multi-position systems requires the researcher to look for and investigate specialized systems of marked code structures used to modulate the probing signals in order to identify them in a joint radar channel. Thus, the problem at hand is how to look for and investigate novel marked code structures used to generate a system of probing signals, the use of which will allow it to be "attached" to a specific receiving-transmitting position of a multi-position onboard system and to identify them in a joint radar channel in the course of the remote sensing of the underlying surface. The purpose of this work is to conduct a study on the subject of the squeak and choice of a system of code structures that have a low level of side lobes of autocorrelation functions and uniformly distributed values of the levels of the cross-correlation function. To achieve this goal, the relevance of the study is substantiated in the introduction. The second section analyzes the level of side lobes for classical and modified Barker codes with an asymmetric alphabet. On the basis of this analysis, it was concluded that it is expedient to apply this approach for codes longer than Barker codes. Therefore, in the third section, the features of the generation of M-sequences are considered. The fourth section presents a technique for searching for new marked code structures, taking into account their mutual correlation properties for modifying M-sequences in order to implement multi-positional systems. The fifth section presents computer experiments on the search for marked code structures based on the modifications of M-sequences and presents the numerical characteristics of the correlation properties of the considered marked codes. And finally, in the sixth section, the final conclusions of the study are presented and recommendations are given for their further practical application. The practical significance of this study lies in the fact that the proposed new marked code structures are necessary for the synthesis of probing signals in the implementation of spatially distributed systems that function for the high-probability detection and high-precision determination of the coordinates of physical objects and are also necessary for the formation of radar images in a multi-position mode.
PubMed: 37571618
DOI: 10.3390/s23156835 -
European Child & Adolescent Psychiatry Apr 2024
PubMed: 38261032
DOI: 10.1007/s00787-023-02360-z -
The American Journal of Medicine Dec 2017The aim of this study was to investigate the association of albumin levels on admission and change in levels during hospitalization with hospitalization outcomes.
BACKGROUND
The aim of this study was to investigate the association of albumin levels on admission and change in levels during hospitalization with hospitalization outcomes.
METHODS
Historical prospective data of patients hospitalized between 2011 and 2013 were collected. Levels of albumin were classified as marked hypoalbuminemia (<2.5 mg/dL), mild hypoalbuminemia (2.5-3.5 mg/dL), normal albumin (3.5-4.5 mg/dL), and hyperalbuminemia (>4.5 mg/dL). Main outcomes were length of hospitalization, in-hospital mortality, and long-term mortality.
RESULTS
The cohort included 30,732 patients (mean age 67 ± 18 years, 51% male). Most patients had normal albumin levels on admission (n = 20,124, 65%), 29% of patients had hypoalbuminemia, mostly mild (n = 7,334, 24%), and 5% of patients had marked hypoalbuminemia (n = 1436). Hyperalbuminemia on admission was evident in 6% of the patients (n = 1838). Follow-up (median ± standard deviation) was 1675 ± 325 days. Compared with in-hospital mortality with normal albumin on admission (2%), mortality was higher with mild (12%) and marked hypoalbuminemia (34%) and lower with hyperalbuminemia (0.3%). Mortality rate at the end of follow-up was 29% with normal albumin levels, 67% and 83% with mild and marked hypoalbuminemia, respectively. Patients with hyperalbuminemia on admission and before discharge have the best short- and long-term survival. This pattern was similar when analyzed separately in different age groups. In patients with hypoalbuminemia on admission, normalization of albumin levels before discharge was associated with better short- and long-term survival, compared with patients with hypoalbuminemia before discharge.
CONCLUSIONS
Low albumin levels on admission are associated with increased short- and long-term mortality. Normalization of albumin levels before discharge was associated with lower mortality risk, compared with hypoalbuminemia before discharge.
Topics: Adult; Aged; Aged, 80 and over; Female; Follow-Up Studies; Hospital Mortality; Hospitalization; Humans; Hypoalbuminemia; Male; Middle Aged; Retrospective Studies; Risk Assessment
PubMed: 28803138
DOI: 10.1016/j.amjmed.2017.07.020