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Lymphatic Research and Biology Jun 2021Until now, lymphatic ultrasound was performed with the patients in the prone position. The aim of this study was to evaluate the change in the lymphatic diameter in...
Until now, lymphatic ultrasound was performed with the patients in the prone position. The aim of this study was to evaluate the change in the lymphatic diameter in different body positions. We performed a retrospective study. We performed indocyanine green (ICG) lymphography and lymphatic ultrasound as a pre-operative examination for lymphaticovenous anastomosis (LVA). ICG was injected at three lymphosomes per limb (the saphenous lymphatics, lateral thigh lymphatics, and lateral calf lymphatics). For the lymphatic ultrasound, a commonly used ultrasound device with an 18 MHz linear probe was employed. We measured the lymphatic diameter in the designed LVA sites in prone, sitting, and upright position. We investigated 61 limbs of 31 female patients with lower limb lymphedema. The mean age was 62.0 (range: 42-86) years. We measured the lymphatic diameter at 78 sites in the thigh and 76 sites in the lower leg. In the thigh, the mean lymphatic diameters in the supine and upright positions were 0.43 ± 0.02 mm and 0.40 ± 0.02 mm, respectively, with no significant difference ( = 0.10). In the lower leg, the mean lymphatic diameters in the supine, sitting, and upright positions were 0.68 ± 0.04 mm, 0.63 ± 0.04 mm, and 0.63 ± 0.04, respectively. A significant decrease was noted between the supine and sitting positions ( = 0.02). The lymphatic diameter in the lymphedematous lower limbs tended to decrease when the patients changed their body position from supine to the sitting or upright positions.
Topics: Female; Humans; Indocyanine Green; Lymphatic Vessels; Lymphedema; Lymphography; Middle Aged; Retrospective Studies
PubMed: 33058749
DOI: 10.1089/lrb.2020.0081 -
European Heart Journal. Cardiovascular... Jun 2022The role of atherosclerosis in the pathogenesis of aortic enlargement is uncertain. We aimed to evaluate the relationship between the diameters of the ascending,...
AIMS
The role of atherosclerosis in the pathogenesis of aortic enlargement is uncertain. We aimed to evaluate the relationship between the diameters of the ascending, descending and abdominal aorta, and coronary artery calcification.
METHODS AND RESULTS
Individuals in the Copenhagen General Population Study underwent thoracic and abdominal computed tomography. Maximal aortic diameters were measured in each aortic segment and coronary artery calcium scores (CACS) were calculated. Participants were stratified into five predefined groups according to CACSs and compared to aortic dimensions. The relation between aortic diameter and CACS was adjusted for risk factors for aortic dilatation in a multivariable model. A total of 2678 eligible individuals were included. In all segments of the aorta, aortic diameter was associated to CACSs, with mean increases in aortic diameters ranging from 0.7 to 3.5 mm in individuals with calcified coronary arteries compared to non-calcified subjects (P-value < 0.001). After correction for risk factors, individuals with CACS above 400 had larger ascending, descending and abdominal aortic diameter than the non-calcified reference group (P-value < 0.01).
CONCLUSION
Enlarged thoracic and abdominal aortic vascular segments are associated with co-existing coronary artery calcification in the general population.
Topics: Aorta, Abdominal; Aortic Diseases; Coronary Artery Disease; Humans; Risk Factors; Vascular Calcification
PubMed: 34166489
DOI: 10.1093/ehjci/jeab122 -
Annals of Vascular Surgery Feb 2021Aneurysm sac remodeling is a complex multifactorial process with unknown factors influencing sac regression after endovascular aortic aneurysm repair (EVAR). We sought...
BACKGROUND
Aneurysm sac remodeling is a complex multifactorial process with unknown factors influencing sac regression after endovascular aortic aneurysm repair (EVAR). We sought to identify factors associated with this process by analyzing data obtained from patients treated with the GORE EXCLUDER endovascular aneurysm repair (EVAR) endoprosthesis from December 2010 to October 2016 enrolled in the Global Registry for Endovascular Aortic Treatment (GREAT).
METHODS
All patients enrolled in GREAT with three years CT angiography (CTA) follow-up in each of the three successive years after EVAR were included. The percentage of sac size reduction toward device diameter was calculated and used as a surrogate for sac regression with the formula used being: sac size reduction = ((AAA baseline diameter - AAA diameter at follow-up)/(AAA baseline diameter - device diameter))∗100. The cohort was divided into two groups in accordance with the percentage of aneurysm sac reduction at three years; one with the top quartile of patients and the other with the lowest three quartiles. Demographic and procedural variables were analyzed using univariate and regression modeling to determine factors predictive of sac regression.
RESULTS
There were 3265 subjects enrolled with follow-up as of May 2018 of which 526 (16.2%) had three years of CTA surveillance. Overall aneurysm sac size decreased from a mean of 58.0 mm (Std Dev: 10.4, range: 34.2, 100.0) to a mean of 49.3 mm (Std Dev: 14.1, range: 0, 140) for a percentage reduction toward device diameter of a mean 28.2% (Std Dev: 39.0, range: -103.7, 183.9). On multivariate logistic regression model; two factors proved to be statistically significant contributors to a larger percentage reduction in aneurysm sac: a conical neck (odds ratio [OR] = 1.64, P-value = 0.023) and a larger proximal device diameter (OR = 1.09, P-value = 0.023). On the other hand, two factors were negative predictors of sac shrinkage, namely: old age (OR = 0.96, P-value = 0.002) and larger baseline aneurysm sac diameter (OR = 0.98, P-value = 0.028).
CONCLUSIONS
Aneurysms with conical necks and larger proximal device neck diameters have an increased percentage change in sac size over time after EVAR. Older age and larger initial diameters of aneurysms were negatively associated with percentage change in sac size as well as sac regression. Further study is needed to determine the clinical utility of these observations and applicability across multiple endoprosthesis platforms.
Topics: Age Factors; Aged; Aged, 80 and over; Aortic Aneurysm; Aortography; Australia; Blood Vessel Prosthesis; Blood Vessel Prosthesis Implantation; Brazil; Computed Tomography Angiography; Endovascular Procedures; Europe; Female; Humans; Male; Middle Aged; New Zealand; Prosthesis Design; Registries; Retrospective Studies; Risk Assessment; Risk Factors; Time Factors; Treatment Outcome; United States; Vascular Remodeling
PubMed: 32889165
DOI: 10.1016/j.avsg.2020.08.110 -
Archivio Italiano Di Urologia,... Mar 2022The objective of this study was to assess the relationship between retinal vessel diameters, such as retinal arteriolar diameter, retinal venular diameter, and...
OBJECTIVE
The objective of this study was to assess the relationship between retinal vessel diameters, such as retinal arteriolar diameter, retinal venular diameter, and arteriolar/venular ratio (AVR), as clinical parameters of fertility in varicocele patients.
MATERIALS AND METHODS
Sixty-eight (68) infertile varicocele men with abnormal semen parameters and sixty-one (61) varicocele normozoospermic men were included in the study. Moreover, fifty-eight (58) healthy normozoospermic men without varicocele were enrolled as a control group. For each participant, retinal vascular diameters were measured from the digital retinal photographs as a central retinal arteriolar equivalent (CRAE), central retinal venular equivalent (CRVE), and AVR. In addition, hormones (total testosterone and FSH), and semen parameters were assessed and correlated with retinal vessel diameters.
RESULTS
The mean CRAE, CRVE, and AVR values were 147.8 ± 15.8 μm, 198.3 ± 39.3 μm, and 0.61 ± 0.01 in infertile varicocele patients, respectively. Significant difference of CRAE, CRVE, and AVR were found when comparing infertile varicocele patients with both varicocele and control normozoospermic male groups (p = 0.01, p = 0.006, and p = 0.007; respectively). Larger retinal venular caliber and smaller AVR ratio showed a significant inverse correlation with both sperm parameters and hormones (total testosterone and FSH) (p < 0.05). No significant correlations were found between CRAE with both sperm parameters and hormonal values (total testosterone and FSH) (p > 0.05).
CONCLUSIONS
Infertile patients with varicocele showed a significant relationship with the retinal vascular diameter (CRVE and AVR ratio). This finding supports recommendation for regular eye examinations in the varicocele population.
Topics: Humans; Infertility; Male; Photography; Retinal Vessels; Varicocele
PubMed: 35352529
DOI: 10.4081/aiua.2022.1.70 -
Cureus Jun 2023Background The inconsistent morphology of the scapula is based on variable dimensions of its glenoid cavity, in addition to its broadened and truncated lateral angle....
Background The inconsistent morphology of the scapula is based on variable dimensions of its glenoid cavity, in addition to its broadened and truncated lateral angle. Its variable shapes are attributed to the spinoglenoid cavity (superior and posterior aspect of the scapula), which appears oval, inverted comma-shaped, and piriform (pear-shaped). Traumatic conditions often lead to glenoid dislocation/fracture. The precise administration of total shoulder arthroplasty with glenoid component adjustment warrants a comprehensive knowledge of scapular morphology. This study aims to assess the glenoid cavity/scapula shapes (anthropometric assessment) among individuals located in Odisha, India. Methods This cross-sectional analysis was undertaken on 74 left-sided and 70 right-sided, dry, and undeteriorated scapulae of human adult specimens obtained from the anatomy department irrespective of their gender and age. Results The glenoid cavity was most commonly inverted comma-shaped (34.02%) and pear-shaped (48.61%) while 17.36% of scapulae had oval-shaped glenoid cavities. The mean scapular breadth and length dimensions were 98.12±7.87mm and 135.76±12.85mm, respectively. Statistically insignificant bilateral variations were observed between the glenoid cavity index (mean value: 68.44±7.98%), glenoid diameter-2 (anteroposterior; mean value: 16.17±2.24mm), glenoid diameter-1 (anteroposterior; mean value: 22.67±1.53mm), and glenoid diameter (superoinferior; mean value: 36.03±2.15mm). Conclusion The size and shape of the glenoid cavity are directly associated with the dislocation of the shoulder joint and may disturb the results of total shoulder arthroplasty and rotator cuff surgeries. The current study analyzed the morphological types and diameters of the glenoid cavity in the scapulae to improve efficiency and lessen the failure proportions in shoulder arthroplasty. The study shows that morphological measurement of scapulae plays a vital role in the effective maintenance of posture and shoulder functions.
PubMed: 37415989
DOI: 10.7759/cureus.39981 -
Paediatric Anaesthesia Apr 2021Balloon-tipped bronchial blocker catheters are widely used in pediatric thoracic anesthesia to establish single-lung ventilation. In clinical practice, their balloons...
Inflation volume-balloon diameter and inflation pressure-balloon diameter characteristics of commonly used bronchial blocker balloons for single-lung ventilation in children.
BACKGROUND
Balloon-tipped bronchial blocker catheters are widely used in pediatric thoracic anesthesia to establish single-lung ventilation. In clinical practice, their balloons demonstrate sudden expansion when inflated with air. In addition, there are concerns related to the high inflation pressures required to expand the balloons.
METHODS
This in vitro study assessed inflation volume- and inflation pressure-balloon diameter characteristics of the Fogarty arterial embolectomy catheters and Arndt endobronchial blockers. Balloon diameters were photographically assessed during unrestricted volume- and pressure-guided inflation, using air up to the maximum allowed inflation volume as indicated by the manufacturers. Inflation pressures required to open the blocker balloons and inflation pressures needed to expand them to maximum indicated diameter were measured.
RESULTS
Volume-guided inflation demonstrated a late acute rise in diameter in Fogarty blocker balloons, whereas in the Arndt endobronchial blocker balloons almost linear inflation volume-to-diameter characteristics were observed. Pressure-guided inflation on the other hand demonstrated low-volume, high-pressure characteristics in the Fogarty blocker balloons, with inflation pressures required to expand the balloons to maximum diameters ranging from (mean (SD)) 636 (75) to 947 (152) cmH O. The inflation pressures required to open the Fogarty blocker balloons were even >1000 cmH O. Inflation pressures required to expand the 5 F, 7 F, and 9 F Arndt endobronchial blocker balloons to maximum indicated diameter were much lower, namely at 218 (15), 252 (28), and 163 (8) cmH O.
CONCLUSION
Based on these study findings, the balloons of Fogarty arterial embolectomy catheters represent high-pressure devices and do not permit stepwise controlled bronchial blockage. The Arndt endobronchial blockers have some advantages over the Fogarty blocker devices, but also represent high-pressure equipment and must be used with caution and limited duration. Manufacturers are asked to design pediatric endobronchial blocker catheters with truly high-volume, low-pressure balloons in accordance to age-related pediatric airway dimensions.
Topics: Bronchi; Catheterization; Child; Humans; Insufflation; One-Lung Ventilation
PubMed: 33406307
DOI: 10.1111/pan.14123 -
Journal of Personalized Medicine May 2022To investigate the association between Aorta (Ao), pulmonary artery (PA) diameters and the PA/Ao ratio with right (RV) and left ventricle (LV) volumetric properties in...
To investigate the association between Aorta (Ao), pulmonary artery (PA) diameters and the PA/Ao ratio with right (RV) and left ventricle (LV) volumetric properties in subjects free of cardiovascular diseases. In the KORA-MRI study, 339 subjects (mean age 56.3 ± 9.1 years; 43.7% female) underwent whole-body 3T-MRI. Ao and PA were measured on DIXON sequences. Cvi42 quantified cardiac functional parameters from a SSFP sequence. The relationship between ascending (AAo), and descending aorta (DAo), as well as PA diameters, and RV and LV function were assessed using linear regression models adjusted for age, sex, and cardiovascular risk factors. AAo and DAo diameter were associated with LV end-diastolic volume (β = 4.52, = 0.015; ß = 7.1, ≤ 0.001), LV end-systolic volume (β = 2.37, = 0.031; ß = 3.66, = 0.002), while DAo associated with RV end-diastolic volume (β = 6.45, = 0.006) and RV end-systolic volume (β = 3.9, = 0.011). PA diameter was associated with LV end-diastolic volume (β = 4.81, = 0.003). Interestingly, the PA/Ao ratio was only associated with RV end-diastolic and end-systolic volume (β = 4.48, = 0.029; ß = 2.82, = 0.037). Furthermore, we found different relationships between men and women. Ao and PA diameter were associated with LV and RV volumetric parameters in subjects free of cardiovascular diseases suggesting that ventricular volumetric performance directly relates to vascular diameter properties.
PubMed: 35743674
DOI: 10.3390/jpm12060889 -
Ophthalmic & Physiological Optics : the... Sep 2022To investigate the validity of Placido-based corneal topography parameters to predict corneoscleral sagittal heights measured by Fourier-based profilometry at various...
PURPOSE
To investigate the validity of Placido-based corneal topography parameters to predict corneoscleral sagittal heights measured by Fourier-based profilometry at various diameters.
METHODS
Minimal (Min ), maximal (Max ) sagittal height, toricity (Max - Min ) and axis of the flattest meridian (Min ) of 36 subjects (mean age 25.4 SD ± 3.2 years; 21 female) were measured using the Eye Surface Profiler and analysed for diameters (chord length) of 8 to 16 mm (in 2-mm intervals). Furthermore, corneal central radii, corneal astigmatism, eccentricity and diameter were measured using the Keratograph 5 M.
RESULTS
Using multiple linear regression analysis, the best equation for predicting the sagittal heights for 8 mm (r = 0.95), and 10 mm (r = 0.93) diameters included corneal central radii and eccentricity. The best equation for predicting sagittal heights for 12 mm (r = 0.86), 14 mm (r = 0.78) and 16 mm (r = 0.65) diameters included corneal central radii, eccentricity and corneal diameter. Corneal astigmatism was significantly correlated with sagittal height toricity for 8 and 10 mm diameters (r = 0.50 and 0.29; p < 0.01), while no correlation was observed for 12, 14 and 16 mm diameters (p = 0.18 to p = 0.76). The axis of the flattest corneal meridian measured by Placido-based topography was significantly correlated with the axis of the flattest meridian measured by Fourier-based profilometry for 8, 10 and 12 mm diameters (r = 0.17 to 0.44; p < 0.05), while there was no correlation for 14 and 16 mm diameters (p = 0.48 and p = 0.75). For a typical soft contact lens diameter of 14 mm, 78% of the variance could be determined with a corneal topographer and 68% with keratometry and corneal diameter measurement.
CONCLUSIONS
The combination of corneal central radii, eccentricity and corneal diameter measured by Placido-based topography is a valid predictor of the corneoscleral sagittal height in healthy eyes. Scleral toricity and axis of the flattest meridian seem to be independent from Placido-based corneal parameters and requires additional measuring tools.
Topics: Adult; Astigmatism; Contact Lenses, Hydrophilic; Cornea; Corneal Diseases; Corneal Topography; Female; Humans; Sclera
PubMed: 35703419
DOI: 10.1111/opo.13017 -
AJR. American Journal of Roentgenology Jun 2020The purpose of this study was to evaluate size criteria for retroperitoneal and pelvic lymph nodes in healthy children. We identified all trauma patients younger than...
The purpose of this study was to evaluate size criteria for retroperitoneal and pelvic lymph nodes in healthy children. We identified all trauma patients younger than 18 years old without underlying disease and with CT scans without abnormalities in the abdomen and pelvis during 2014-2015. Two pediatric radiologists reviewed the studies independently and recorded the number of retroperitoneal and pelvic lymph nodes with a long diameter 5 mm or greater and the size (two perpendicular diameters) of the largest lymph node in five anatomic locations. Discrepant results were reviewed in consensus. The relationship of short diameter to age and interobserver variability was evaluated. A total of 166 patients (86 boys) with a mean age of 7.2 years old (range, 0.1-18.0 years old) were identified. More than 95% of lymph nodes in the retroperitoneum and pelvis had a short diameter measuring at most 7 and 8 mm, respectively, by consensus. The size of the largest short diameter of lymph nodes did not vary with age. More than four lymph nodes were identified in any anatomic location in only three patients, by only one of the radiologists. Agreement for lymph nodes with largest diameter of 5 mm or greater between radiologists ranged from 70.5% to 97.6% for the five anatomic locations with poor interobserver agreement (κ, 0.2-0.3). The size and number of retroperitoneal and pelvic lymph nodes in children are less than in adults. A short diameter threshold of 7 mm (retroperitoneal) and 8 mm (pelvic) and more than four lymph nodes with long diameter of 5 mm or greater in one location may define disease.
Topics: Adolescent; Child; Child, Preschool; Contrast Media; Female; Humans; Infant; Lymph Nodes; Male; Pelvis; Reference Values; Retroperitoneal Space; Tomography, X-Ray Computed
PubMed: 32228324
DOI: 10.2214/AJR.19.22316 -
Cureus Sep 2021Purpose Variation among aqueous humor outflow from venting slits performed on glaucoma drainage device tubing often occurs even when physician technique and equipment...
Purpose Variation among aqueous humor outflow from venting slits performed on glaucoma drainage device tubing often occurs even when physician technique and equipment are held constant. Our hypothesis is that there are dimensional differences within the tubing, even among the same make and model of glaucoma drainage device (GDD) implants. Methods Prior to surgical implantation, excess glaucoma drainage tubing was collected for analysis. The tubing samples were sliced horizontally, and the external tube, internal lumen, and wall dimension measurements were collected microscopically. Groups were divided based upon brand and model and then statistically analyzed using an independent t-test. A total of 28 tubes were analyzed, consisting of 7 Molteno and 21 Baerveldt implants. Results The mean external diameter for the Molteno group was 656 ± 20µm, significantly larger than the Baerveldt external diameter of 620 ± 13µm (P<0.05). The mean internal diameter among Molteno lumens was 344 ± 13µm, also statistically larger than the mean internal diameter of 309 ± 18µm for Baerveldt tubes (P<0.05). The Molteno luminal wall width varied significantly less than the Baerveldt wall, 18% versus 28%, respectively (P<0.05). The tubings' wall widths variation translated into highly significant off-centered lumens among both brands. Conclusion Our findings suggest that there are significant variations among glaucoma implant dimensions between and within the multiple makes and models. The discrepancies among tubal wall thickness and off-centered lumens are undetectable to the naked eye. Importantly, this may result in significant aqueous humor outflow variation following the creation of venting slits secondary to the found irregular luminal diameters and tube wall thicknesses.
PubMed: 34659982
DOI: 10.7759/cureus.17771