-
Veterinary Dermatology Oct 2021Luliconazole (LCZ) is an imidazole antifungal medication that exhibits excellent activity against dermatophytes. As a topical cream and lotion (approved for human use),...
BACKGROUND
Luliconazole (LCZ) is an imidazole antifungal medication that exhibits excellent activity against dermatophytes. As a topical cream and lotion (approved for human use), LCZ has demonstrated a broad spectrum of activity against human dermatophytoses.
OBJECTIVES
This is the first study to investigate the in vitro susceptibility of clinical isolates from horse dermatophytoses to LCZ.
ANIMALS
No animals were used in this study.
METHODS AND MATERIALS
In the present study, the in vitro susceptibilities of clinical isolates of dermatophytes to LCZ, clotrimazole (CTZ), miconazole (MCZ) and terbinafine (TRF) were investigated using the Clinical & Laboratory Standards Institute M38-A2 test.
RESULTS
The minimum inhibitory concentrations (MICs) for all 16 clinical isolates of Trichophyton equinum, Microsporum equinum/canis and M. gypseum for LCZ were <0.03 mg/L. The MICs of all isolates were <0.03-0.5 mg/L for CTZ, 0.03-16 mg/L for MCZ and <0.03-1 mg/L for TRF.
CONCLUSIONS
LCZ demonstrated a broad spectrum of activity against clinical isolates from horse dermatophytoses. We consider that LCZ will become the primary antifungal agent for treating horse dermatophytosis.
Topics: Animals; Antifungal Agents; Arthrodermataceae; Horses; Japan; Microbial Sensitivity Tests; Microsporum; Trichophyton
PubMed: 34189781
DOI: 10.1111/vde.12993 -
Advanced Biomedical Research 2020Dermatomycoses contain superficial fungal infections of keratinized layers of the body such as skin, hair, and nail that affect more than 20%-25% of people and animals...
BACKGROUND
Dermatomycoses contain superficial fungal infections of keratinized layers of the body such as skin, hair, and nail that affect more than 20%-25% of people and animals worldwide. Some fungi can cause superficial infections in animals after accidental penetration and colonization on injured skin and can be transmitted to humans by exposure. The infection caused mainly by dermatophyte species and may also be caused rarely by yeasts and nondermatophytic molds.
MATERIALS AND METHODS
Eighty-two skin scrapings and hair samples were collected from animals (sheep, cow, cat, camel, calf, goat, horse, and dog) in three specialized pet clinics and three livestock and slaughterhouses. The isolates were identified using direct microscopy, culture, and polymerase chain reaction-sequencing of ITS1-5.8SrDNA-ITS2 region.
RESULTS
Thirteen mold strains out of 82 clinical samples (15.8%) were isolated from animal lesions. ( = 4; 30.7%), ( = 2; 15.4%), ( = 2; 15.4%), ( = 1; 7.7%), ( = 1; 7.7%), ( = 1; 7.7%), ( = 1; 7.7%), and ( = 1; 7.7%) were isolated from clinical specimens.
CONCLUSION
Since opportunistic fungi are increasing as etiological agents of dermatomycoses, isolation of these molds from wounds can be a warning to veterinarians, and daily cleaning of wounds with a proper disinfectant is recommended for the prevention of fungal colonization.
PubMed: 32055538
DOI: 10.4103/abr.abr_230_19