-
Glia May 2023Optic nerve head (ONH) astrocytes provide structural and metabolic support to neuronal axons in developmental, physiological, and pathological progression....
Optic nerve head (ONH) astrocytes provide structural and metabolic support to neuronal axons in developmental, physiological, and pathological progression. Mechanosensitive properties of astrocytes allow them to sense and respond to mechanical cues from the local environment. We confirmed that ONH astrocytes express the mechanosensitive ion channel Piezo1 in vivo. By manipulating Piezo1 knockdown or overexpression in vitro, we found that Piezo1 is necessary but insufficient for ONH astrocyte proliferation. Loss of Piezo1 can lead to cell cycle arrest at G0/G1 phase, a possible mechanism involving decreased yes-associated protein (YAP) nuclear localization and downregulation of YAP-target cell cycle-associated factors, including cyclin D1 and c-Myc. Gene ontology enrichment analysis of differential expression genes from RNA-seq data indicates that the absence of Piezo1 affects biological processes involving cell division. Our results demonstrate that Piezo1 is an essential regulator in cell cycle progression in ONH astrocytes.
Topics: Optic Disk; Astrocytes; Cell Division; Ion Channels; Cell Cycle
PubMed: 36598105
DOI: 10.1002/glia.24334 -
Eye (London, England) Jan 2021Optical coherence tomography (OCT) is a non-invasive medical imaging technology that is playing an increasing role in the routine assessment and management of patients... (Review)
Review
Optical coherence tomography (OCT) is a non-invasive medical imaging technology that is playing an increasing role in the routine assessment and management of patients with neuro-ophthalmic conditions. Its ability to characterise the optic nerve head, peripapillary retinal nerve fibre layer and cellular layers of the macula including the ganglion cell layer enables qualitative and quantitative assessment of optic nerve disease. In this review, we discuss technical features of OCT and OCT-based imaging techniques in the neuro-ophthalmic context, potential pitfalls to be aware of, and specific applications in more common neuro-ophthalmic conditions including demyelinating, inflammatory, ischaemic and compressive optic neuropathies, optic disc drusen and raised intracranial pressure. We also review emerging applications of OCT angiography within neuro-ophthalmology.
Topics: Humans; Ophthalmology; Optic Disk; Optic Disk Drusen; Optic Nerve Diseases; Tomography, Optical Coherence
PubMed: 33239763
DOI: 10.1038/s41433-020-01288-x -
Survey of Ophthalmology 2024Intraretinal or subretinal fluid in the peripapillary area can be clinically visualized in conditions such as peripapillary choroidal neovascularization, optic disc pit... (Review)
Review
Intraretinal or subretinal fluid in the peripapillary area can be clinically visualized in conditions such as peripapillary choroidal neovascularization, optic disc pit maculopathy, and optic nerve head tumors and granulomas. Optical coherence tomography (OCT) helps to visualize peripapillary fluid in many other chorioretinal conditions such as peripapillary pachychoroid syndrome, posterior uveitis, central retinal vein occlusion, malignant hypertension, hypotonic maculopathy as well as neuro-ophthalmological conditions such as glaucoma, microcystic macular edema and disc edema due papilledema, non-arteritic anterior ischemic optic neuropathy, neuroretinitis, and diabetic papillopathy. Often, the differential diagnosis of peripapillary fluid is a bit tricky and may lead to misdiagnosis and improper management. We describe a diagnostic algorithm for peripapillary fluid on OCT and outline the salient features and management of these conditions.
Topics: Humans; Tomography, Optical Coherence; Optic Disk; Subretinal Fluid; Diagnosis, Differential; Retinal Diseases
PubMed: 38016521
DOI: 10.1016/j.survophthal.2023.11.004 -
Ophthalmology Mar 2016
Topics: Female; Humans; Male; Optic Disk; Optic Nerve Diseases; Retina; Tomography, Optical Coherence
PubMed: 26902568
DOI: 10.1016/j.ophtha.2015.09.033 -
Annals of the Academy of Medicine,... Feb 2020
Topics: Glaucoma; Humans; Optic Disk
PubMed: 32246705
DOI: No ID Found -
The British Journal of Ophthalmology Oct 2019Myopic eyes have an increased risk of glaucoma. However, glaucomatous changes in a myopic eye are often difficult to detect. Classic structural and functional... (Review)
Review
Myopic eyes have an increased risk of glaucoma. However, glaucomatous changes in a myopic eye are often difficult to detect. Classic structural and functional investigations to diagnose glaucoma may be confounded by myopia. Here, we identify some of the common pitfalls in interpreting these structural parameters, and the possible solutions that could be taken to overcome them. For instance, in myopic eyes, we discuss the limitations and potential sources of error when using neuroretinal rim parameters, and retinal nerve fibre layer and ganglion cell-inner plexiform layer thickness measurements. In addition, we also review new developments and potential adjuncts in structural imaging such as the assessment of the retinal nerve fibre layer texture, and the examination of the microcirculation of the optic nerve head using optical coherence tomography angiography. For the functional assessment of glaucoma, we discuss perimetric strategies that may aid in detecting characteristic visual field defects in myopic glaucoma. Ultimately, the evaluation of glaucoma in myopia requires a multimodal approach, to allow correlation between structural and functional assessments. This review provides overview on how to navigate this diagnostic dilemma.
Topics: Fluorescein Angiography; Glaucoma; Humans; Microcirculation; Myopia; Nerve Fibers; Optic Disk; Retinal Ganglion Cells; Tomography, Optical Coherence; Vision Disorders; Visual Fields
PubMed: 31040131
DOI: 10.1136/bjophthalmol-2018-313530 -
Journal of Neuro-ophthalmology : the... Jun 2023
Topics: Humans; Papilledema; Optic Disk
PubMed: 37184970
DOI: 10.1097/WNO.0000000000001842 -
Ophthalmology Jul 2023
Topics: Humans; Optic Disk; Intraocular Pressure
PubMed: 36229273
DOI: 10.1016/j.ophtha.2022.08.016 -
Arquivos Brasileiros de Oftalmologia 2022Evaluation of the optic disc is important for the correct diagnosis and follow-up of optic neuropathies, especially glaucoma. The characteristics of the optic disc... (Review)
Review
Evaluation of the optic disc is important for the correct diagnosis and follow-up of optic neuropathies, especially glaucoma. The characteristics of the optic disc depend on various factors, including demographic and population aspects, and analysis of these characteristics may vary according to the methods used. The size and format of the neural rim along with the nerve fiber layer are important to the clinician's judgment regarding the susceptibility of the subject to develop glaucoma. In this study, we reviewed the literature to summarize the main methods and its characteristics in the evaluation of the optic nerve head.
Topics: Humans; Optic Disk; Glaucoma; Optic Nerve Diseases
PubMed: 35170637
DOI: 10.5935/0004-2749.20220080 -
Archives of Pathology & Laboratory... Jan 2017Ischemic optic neuropathy (ION) describes a state of hypoxic injury of the optic nerve. Clinically, ION is divided into anterior and posterior forms defined by the... (Review)
Review
Ischemic optic neuropathy (ION) describes a state of hypoxic injury of the optic nerve. Clinically, ION is divided into anterior and posterior forms defined by the presence or absence of optic disc swelling, respectively. It is further classified as arteritic when secondary to vasculitis, and nonarteritic when not. The site of vascular occlusion for anterior ION from giant cell arteritis is the short posterior ciliary arteries, but mechanical vascular obstruction does not play a role in most nonarteritic cases. Histologically, ION is characterized by axon and glial necrosis, edema, and a sparse mononuclear response. Like other ischemic injuries, the morphologic alternations in the nerve are time dependent. A variant of ION called cavernous degeneration (of Schnabel) features large cystic spaces filled with mucin. Several conditions can histologically mimic cavernous degeneration of the optic nerve. The scarcity of cases of ION examined histologically has contributed to an incomplete understanding of its pathogenesis.
Topics: Arteritis; Diagnosis, Differential; Humans; Optic Disk; Optic Nerve; Optic Neuropathy, Ischemic
PubMed: 28029908
DOI: 10.5858/arpa.2016-0027-RS