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Transplantation Mar 2020
Topics: Ecuador; Female; Geography; History, 20th Century; History, 21st Century; Humans; Intersectoral Collaboration; Male; Organ Transplantation; Quality of Life; Tissue and Organ Procurement
PubMed: 32106198
DOI: 10.1097/TP.0000000000002974 -
Biomedica : Revista Del Instituto... Jun 2017
Topics: Colombia; Humans; Organ Transplantation; Time Factors; Tissue and Organ Procurement
PubMed: 28527275
DOI: 10.7705/biomedica.v37i2.3909 -
Current Opinion in Organ Transplantation Aug 2019To provide an update on the current landscape of antimicrobial stewardship in solid organ transplant (SOT) recipients. (Review)
Review
PURPOSE OF REVIEW
To provide an update on the current landscape of antimicrobial stewardship in solid organ transplant (SOT) recipients.
RECENT FINDINGS
Constructing personalized antimicrobial prescribing approaches to avoid untoward consequences of antimicrobials while improving outcomes is an emerging and critical aspect of transplant medicine. Stewardship activities encompassing the specialized interests of transplant patients and programs are evolving. New literature evaluating strategies to optimize antimicrobial agent selection, dosing, and duration have been published. Additionally, consensus guidance for certain infectious clinical syndromes is available and should inform institutional clinical practice guidelines. Novel metrics for stewardship-related outcomes in transplantation are desperately needed. Though exciting new molecular diagnostic technologies will likely be pivotal in the care of immunocompromised patients, optimal clinical adaptation and appropriate integration remains unclear. Important studies understanding the behaviors influencing antimicrobial prescribing in organizational transplant cultures are needed to optimize interventions.
SUMMARY
Consequences of antimicrobial use, such as Clostridiodes difficile and infections with multidrug-resistant organisms disproportionately affect SOT recipients and are associated with poor allograft and patient outcomes. Application of ASP interventions tailored to SOT recipients is recommended though further studies are needed to provide guidance for best practice.
Topics: Antimicrobial Stewardship; Humans; Organ Transplantation
PubMed: 31145159
DOI: 10.1097/MOT.0000000000000661 -
The Surgical Clinics of North America Feb 2019The successful development of multivisceral and composite visceral transplantation is among the milestones in the recent history of human organ transplantation. All... (Review)
Review
The successful development of multivisceral and composite visceral transplantation is among the milestones in the recent history of human organ transplantation. All types of gastrointestinal transplantation have evolved to be the standard of care for patients with gut failure and complex abdominal pathologic conditions. The outcome has markedly improved over the last 3 decades owing to technical innovation, novel immunosuppression, and better postoperative care. Recent data documented significant improvement in the long-term therapeutic indices of all types of visceral transplantation close to that achieved with thoracic and solid abdominal organs.
Topics: Graft Survival; Humans; Organ Transplantation; Patient Selection; Terminology as Topic; Treatment Outcome; Viscera
PubMed: 30471738
DOI: 10.1016/j.suc.2018.09.010 -
Arquivos Brasileiros de Cardiologia Aug 2022
Topics: Exercise Therapy; Humans; Organ Transplantation
PubMed: 35946687
DOI: 10.36660/abc.20220373 -
Intensive Care Medicine Mar 2019
Topics: Humans; Organ Transplantation; Prognosis; Treatment Outcome
PubMed: 30483836
DOI: 10.1007/s00134-018-5472-6 -
Cellular Immunology Sep 2020
Topics: Humans; Organ Transplantation; Transplantation Immunology
PubMed: 32619810
DOI: 10.1016/j.cellimm.2020.104156 -
Current Opinion in Organ Transplantation Aug 2019The purpose of the review is an update of diagnosis and treatment of coccidioidomycosis infection in solid organ transplant (SOT) patients. Endemic fungal infections... (Review)
Review
PURPOSE OF REVIEW
The purpose of the review is an update of diagnosis and treatment of coccidioidomycosis infection in solid organ transplant (SOT) patients. Endemic fungal infections continue to be a cause of serious morbidity and mortality in transplant recipients.
RECENT FINDINGS
In transplant patients there are recommendations regarding screening in areas that are endemic for coccidioidomycosis. This screening involves serologic testing and chest imaging. In endemic areas pretransplant seropositivity varies from 1.4 to 5.6%. In immunocompromised patients with elevated complement fixation titers, evaluation of cerebrospinal fluid is recommended even in the absence of symptoms. Although coccidioidomycosis can be a self-limited disease in immunocompotent patients, all SOT patients should be treated regardless of severity. This may include intravenous amphotericin B in severe cases and fluconazole therapy in milder episodes. In those SOT recipients with evidence of prior coccidioidomycosis, lifelong secondary prophylaxis with fluconazole given risk of recurrent disease.
SUMMARY
Coccidioidomycosis continues to be a cause of serious morbidity and mortality in transplant recipients but with proper screening and treatment can be successfully managed.
Topics: Coccidioidomycosis; Humans; Organ Transplantation; Transplant Recipients
PubMed: 31192818
DOI: 10.1097/MOT.0000000000000668 -
Cold Spring Harbor Protocols Mar 2017Ovary transplantation is a useful technique when there is a valuable female mouse (e.g., transgenic, unique allele) that is ill, not breeding, or cannot breed naturally....
Ovary transplantation is a useful technique when there is a valuable female mouse (e.g., transgenic, unique allele) that is ill, not breeding, or cannot breed naturally. The ovaries from the valuable female are transplanted into a histocompatible wild-type female recipient whose ovaries have been surgically removed. The donor ovaries can then function in the wild-type recipient to generate oocytes that will be ovulated and can be fertilized after natural matings. The donor ovaries can be cut into smaller pieces and each piece can be transplanted into separate females. Newborn ovaries or cryorecovered ovaries can also be transplanted. The removal of the recipient ovary leaves the surrounding bursal membrane intact, providing a convenient sac to insert and hold the donor ovary or ovarian fragments.
Topics: Animals; Female; Mice; Organ Transplantation; Ovary
PubMed: 28250216
DOI: 10.1101/pdb.prot094458 -
Pediatrics May 2020The demand for transplantable solid organs far exceeds the supply of deceased donor organs. Patient selection criteria are determined by individual transplant programs;... (Review)
Review
The demand for transplantable solid organs far exceeds the supply of deceased donor organs. Patient selection criteria are determined by individual transplant programs; given the scarcity of solid organs for transplant, allocation to those most likely to benefit takes into consideration both medical and psychosocial factors. Children with intellectual and developmental disabilities have historically been excluded as potential recipients of organ transplants. When a transplant is likely to provide significant health benefits, denying a transplant to otherwise eligible children with disabilities may constitute illegal and unjustified discrimination. Children with intellectual and developmental disabilities should not be excluded from the potential pool of recipients and should be referred for evaluation as recipients of solid organ transplants.
Topics: Child; Developmental Disabilities; Humans; Intellectual Disability; Organ Transplantation; Transplant Recipients
PubMed: 32312907
DOI: 10.1542/peds.2020-0625