Review

Authors: Asghar Ali, Elisabeth Kemter, Eckhard Wolf...

End-stage organ failure can result from various preexisting conditions and occurs in patients of all ages, and organ transplantation remains its only treatment. In recent years, extensive research has been done to explore the possibility of transplanting animal organs into humans, a process referred to as xenotransplantation. Due to their matching organ sizes and other anatomical and physiological similarities with humans, pigs are the preferred organ donor species. Organ rejection due to host immune response and possible interspecies infectious pathogen transmission have been the biggest hurdles to xenotransplantation's success. Use of genetically engineered pigs as tissue and organ donors for xenotransplantation has helped to address these hurdles. Although several preclinical trials have been conducted in nonhuman primates, some barriers still exist and demand further efforts. This review focuses on the recent advances and remaining challenges in organ and tissue xenotransplantation.

Topics: Animals; Humans; Swine; Transplantation, Heterologous; Organ Transplantation; Genetic Engineering; Transplants

PubMed: 37906838
DOI: 10.1146/annurev-animal-021122-102606

Authors: Carla Prezioso, Valeria Pietropaolo

As guest editors, we are pleased to present this Special Issue on BK virus (BKV) and transplantation with the intention of exploring some aspects related to BKV-associated diseases in transplant recipients, since they are still unclear [...].

Topics: BK Virus; Disease Susceptibility; Humans; Kidney Transplantation; Organ Transplantation; Polyomavirus Infections; Transplant Recipients; Tumor Virus Infections

PubMed: 33922350
DOI: 10.3390/v13050733

Authors: Olivier Detry, Dominique Van Deynse, Hans Van Vlierberghe...

Topics: Belgium; Delivery of Health Care, Integrated; Diffusion of Innovation; Forecasting; Health Policy; History, 20th Century; History, 21st Century; Humans; Models, Organizational; Organ Transplantation; Policy Making; Time Factors; Tissue Donors; Tissue and Organ Procurement; Waiting Lists

PubMed: 28832443
DOI: 10.1097/TP.0000000000001866

The International thoracic organ transplant registry of the international society for heart and lung transplantation: Thirty-ninth adult heart transplantation report-2022; focus on transplant for restrictive heart disease.

Authors: Eileen Hsich, Tajinder P Singh, Wida S Cherikh...

Topics: Adult; Heart Diseases; Heart Transplantation; Heart-Lung Transplantation; Humans; Lung Transplantation; Organ Transplantation; Registries; Societies, Medical; Survival Rate

PubMed: 36031520
DOI: 10.1016/j.healun.2022.07.018

Authors: Larry A Weinrauch, John A D'Elia

Topics: Air Pollution; Heart Transplantation; Organ Transplantation

PubMed: 32498817
DOI: 10.1016/j.jacc.2020.01.065

Authors: Frederike Ambagtsheer, Coby Annema, John Forsythe...

Topics: Humans; Tissue and Organ Procurement; Organ Transplantation; Tissue Donors

PubMed: 38655205
DOI: 10.3389/ti.2024.13011

Authors: Sanjay Rajagopalan, Sadeer G Al-Kindi

Topics: Air Pollution; Heart Transplantation; Humans; Organ Transplantation; Tissue and Organ Procurement

PubMed: 32498819
DOI: 10.1016/j.jacc.2020.04.025

Authors: Tong Wu, Yangyang Wu, Kebing Nie...

AIM

The purpose of this study was to characterize publication patterns, academic influence, research trends, and the recent developments in uterus transplantation (UTx) across the globe.

METHODS

The Web of Science Core Collection database was searched for documents published from the time the database began to include relevant articles to 15 December 2023. With the use of VOSviewer, Citespace, BICOMB, and Incites, a cross-sectional bibliometric analysis was conducted to extract or calculate the evaluative indexes. Publications were categorized by country, institution, author, journal, highly cited papers, and keywords. The variables were compared in terms of publication and academic influence, which further included citation count, citation impact, Hirsh index, journal impact factor, total link strength, collaboration metrics, and impact relative to the world.

RESULTS

A total of 581 papers concerning UTx were initially identified after retrieval, and 425 documents were included. Of the 41 countries participating in relevant studies, the USA and Sweden were in leading positions in terms of publications, citations, and academic influence. The most versatile institution was the University of Gothenburg, followed by Baylor University. The most productive scholars and journals were Brännström M. and Fertility and Sterility , respectively. Five groups of cutting-edge keywords were identified: venous drainage, donors and donation, women, fertility preservation, and fertility. Topics about surgery, first live birth, risk, and in vitro fertilization remain hot in this field.

CONCLUSIONS

UTx is anticipated to enter a golden era in the coming years. This study provides some guidance concerning the authors involved in promoting UTx research, the current development of UTx, and journals to submit their innovative research. This also helps to reach a comprehensive insight and prospect in the near future. In order to establish recognized standards and benefit more patients who are disturbed by uterine infertility, large-scale and well-designed clinical trials are required.

Topics: Humans; Bibliometrics; Female; Uterus; Organ Transplantation; Cross-Sectional Studies; Journal Impact Factor

PubMed: 38626445
DOI: 10.1097/JS9.0000000000001470

Review

Authors: Craig S Brown, Glenn K Wakam, Michael J Englesbe...

PURPOSE OF REVIEW

The development and implementation of 'increased risk donor' (IRD) status by the Centers for Disease Control (CDC) was intended to guide patients and providers in decision making regarding risk of infectious transmission via solid organ transplantation. Several contemporary studies have shown underutilization of these organs. This review summarizes the issues surrounding IRD status as well as recent advances in our understanding of the risks and benefits of increased risk organs and their appropriate utilization.

RECENT FINDINGS

Risk of window-period infection remains exceedingly low, and implementation of nucleic acid testing for HIV and hepatitis C virus (HCV) has resulted in decreasing risk of window-period infection often by an order of magnitude or more. Surgeons remain hesitant to utilize IRD organs. In addition, surgeon assessment of risk by donor behaviour was often discordant with known risks of those behaviours. Studies investigating outcomes of utilization of IRD organs suggest long-term mortality and graft survival is at least equivalent to non-IRD organs. Contemporary results suggest that IRD organs continue to be underutilized, particularly adult kidneys and lungs, with hundreds of wasted organs per year.

SUMMARY

CDC IRD labelling has led to an underutilization of organs for transplantation. The risks associated with acceptance of an IRD organ are inflated by surgeons and patients, and outcomes for patients who undergo transplantation with increased risk organs are similar to or better than those for patients whom accept standard risk organs. The rate of transmission of window-period infection from IRD organs is exceptionally low. The harms regarding the utility of Public Health Service increased risk classification outweigh the benefits for patients in need of transplant.

Topics: Humans; Organ Transplantation; Risk Factors; Tissue Donors

PubMed: 32073497
DOI: 10.1097/MOT.0000000000000735

Authors: Alexandra K Glazier

Topics: Health Care Rationing; Health Policy; Humans; Organ Transplantation; Resource Allocation; Tissue Donors; Tissue and Organ Procurement

PubMed: 31267655
DOI: 10.1111/ajt.15521