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BMC Anesthesiology Mar 2019
Topics: Anesthesiology; Animals; Humans; Organ Transplantation; Specialization
PubMed: 30832567
DOI: 10.1186/s12871-019-0704-z -
Viruses Apr 2021As guest editors, we are pleased to present this Special Issue on BK virus (BKV) and transplantation with the intention of exploring some aspects related to...
As guest editors, we are pleased to present this Special Issue on BK virus (BKV) and transplantation with the intention of exploring some aspects related to BKV-associated diseases in transplant recipients, since they are still unclear [...].
Topics: BK Virus; Disease Susceptibility; Humans; Kidney Transplantation; Organ Transplantation; Polyomavirus Infections; Transplant Recipients; Tumor Virus Infections
PubMed: 33922350
DOI: 10.3390/v13050733 -
Transplantation Sep 2017
Topics: Belgium; Delivery of Health Care, Integrated; Diffusion of Innovation; Forecasting; Health Policy; History, 20th Century; History, 21st Century; Humans; Models, Organizational; Organ Transplantation; Policy Making; Time Factors; Tissue Donors; Tissue and Organ Procurement; Waiting Lists
PubMed: 28832443
DOI: 10.1097/TP.0000000000001866 -
Journal of the American College of... Jun 2020
Topics: Air Pollution; Heart Transplantation; Organ Transplantation
PubMed: 32498817
DOI: 10.1016/j.jacc.2020.01.065 -
American Journal of Transplantation :... Dec 2020
Topics: Animals; Mice; Models, Theoretical; Organ Transplantation; Urinary Bladder; Vascularized Composite Allotransplantation
PubMed: 32406153
DOI: 10.1111/ajt.16008 -
The Journal of Heart and Lung... Oct 2022
The International thoracic organ transplant registry of the international society for heart and lung transplantation: Thirty-ninth adult heart transplantation report-2022; focus on transplant for restrictive heart disease.
Topics: Adult; Heart Diseases; Heart Transplantation; Heart-Lung Transplantation; Humans; Lung Transplantation; Organ Transplantation; Registries; Societies, Medical; Survival Rate
PubMed: 36031520
DOI: 10.1016/j.healun.2022.07.018 -
American Journal of Transplantation :... Jan 2016While the costs to Medicare of solid organ transplants are varied and considerable, the total Medicare expenditure of $4.2 billion for solid organ transplant recipients...
While the costs to Medicare of solid organ transplants are varied and considerable, the total Medicare expenditure of $4.2 billion for solid organ transplant recipients in 2013 remains less than 1% of all Medicare expenditures. Kidney transplant remains one of the most cost-effective surgical interventions in medicine and exhibits a rare feature in that it is generally known to be cost-saving in the long term. For patients covered by Medicare, lung transplant is one of the more costly solid organ transplants performed. This chapter reports pretransplant costs for lung candidates to allow investigators to further explore the relative cost of lung transplant compared with alternative management.
Topics: Adolescent; Adult; Aged; Child; Child, Preschool; Cost-Benefit Analysis; Health Care Costs; Humans; Infant; Infant, Newborn; Medicare; Middle Aged; Models, Economic; Organ Transplantation; Patient Readmission; United States; Young Adult
PubMed: 26755268
DOI: 10.1111/ajt.13672 -
EBioMedicine Nov 2020
Topics: Humans; Organ Transplantation; Quality Improvement; Tissue and Organ Procurement
PubMed: 33213763
DOI: 10.1016/j.ebiom.2020.103135 -
Acta Haematologica 2020Amyloidosis comprises a diverse group of diseases characterized by misfolding of precursor proteins which eventually form amyloid aggregates and preceding... (Review)
Review
Amyloidosis comprises a diverse group of diseases characterized by misfolding of precursor proteins which eventually form amyloid aggregates and preceding intermediaries, which are deposited in target tissues causing progressive organ damage. In all forms of amyloidosis, vital organs may fail; depending on the specific amyloidosis type, this may occur rapidly or progress slowly. Beyond therapies to reduce the precursor protein (chemotherapy for light chain [AL] amyloidosis, anti-inflammatory therapy in serum A amyloid-osis [AA], and antisense RNA therapy in transthyretin amyloidosis [ATTR]), organ transplantation may also be a means to reduce amyloidogenic protein, e.g., in types of amyloid-osis in which the variant precursor is produced by the liver. Heart transplantation is a life-saving approach to the treatment of patients with advanced cardiac amyloidosis; however, amyloidosis may still be considered a contraindication to the procedure despite data supporting improved outcomes, similar to patients with other indications. Kidney transplantation is associated with particularly favorable outcomes in patients with amyloidosis, especially if the precursor protein has been eliminated. Overall, outcomes of solid organ transplantation are improving, but more data are needed to refine the selection criteria and the timing for organ transplantation, which should be performed in highly experienced centers involving multidisciplinary teams with close patient follow-up to detect amyloid recurrence.
Topics: Amyloidosis; Disease Management; Humans; Immunoglobulin Light-chain Amyloidosis; Organ Transplantation; Treatment Outcome
PubMed: 32535598
DOI: 10.1159/000508262 -
Annual Review of Animal Biosciences Feb 2024End-stage organ failure can result from various preexisting conditions and occurs in patients of all ages, and organ transplantation remains its only treatment. In... (Review)
Review
End-stage organ failure can result from various preexisting conditions and occurs in patients of all ages, and organ transplantation remains its only treatment. In recent years, extensive research has been done to explore the possibility of transplanting animal organs into humans, a process referred to as xenotransplantation. Due to their matching organ sizes and other anatomical and physiological similarities with humans, pigs are the preferred organ donor species. Organ rejection due to host immune response and possible interspecies infectious pathogen transmission have been the biggest hurdles to xenotransplantation's success. Use of genetically engineered pigs as tissue and organ donors for xenotransplantation has helped to address these hurdles. Although several preclinical trials have been conducted in nonhuman primates, some barriers still exist and demand further efforts. This review focuses on the recent advances and remaining challenges in organ and tissue xenotransplantation.
Topics: Animals; Humans; Swine; Transplantation, Heterologous; Organ Transplantation; Genetic Engineering; Transplants
PubMed: 37906838
DOI: 10.1146/annurev-animal-021122-102606