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Journal of Pharmacological and... 2018
Topics: Animals; Cardiology; Drug Evaluation, Preclinical; Drug and Narcotic Control; Drug-Related Side Effects and Adverse Reactions; Humans; Pharmacology; Safety
PubMed: 29936032
DOI: 10.1016/j.vascn.2018.06.004 -
Behavioural Pharmacology Apr 2018
Topics: Animals; Behavior; Brain; Gastrointestinal Microbiome; Humans; Pharmacology
PubMed: 29543646
DOI: 10.1097/FBP.0000000000000401 -
Pharmaceutical Research Oct 2018
Topics: Chemistry, Pharmaceutical; Drug Compounding; Drug Development
PubMed: 30338408
DOI: 10.1007/s11095-018-2510-6 -
Pharmacological Research Sep 2017
Topics: Animals; Clinical Trials as Topic; Drug Discovery; Female; Humans; Male; Pharmacology; Sex Characteristics; Sex Factors
PubMed: 28694145
DOI: 10.1016/j.phrs.2017.07.001 -
Biochemistry Oct 2017Genetics and pharmacology are often seen as two distinct approaches to interrogating, elucidating, and manipulating biological systems. The former is renowned for its... (Review)
Review
Genetics and pharmacology are often seen as two distinct approaches to interrogating, elucidating, and manipulating biological systems. The former is renowned for its precision whereas the latter for its fast kinetics, reversibility, and practicality. Here, we show that both can be joined as "tethered pharmacology", wherein a genetically programmed bioconjugation site provides selectivity and a tethered pharmacophore provides function. The speed of onset, and especially cessation, of pharmacological activity can be greatly enhanced by incorporating photoswitches and using light as the trigger ("tethered photopharmacology"). Genetically encoded, tethered photopharmacology is a variant of optogenetics and could even play a role in medicine wherever gene therapy is viable. However, gene therapy may not be necessary if sufficiently selective tethering strategies that operate on wild-type receptors can be developed.
Topics: Humans; Optogenetics; Pharmacology; Time Factors
PubMed: 28876905
DOI: 10.1021/acs.biochem.7b00687 -
Pharmacological Reviews Jun 2024
Topics: Precision Medicine; Humans; Clinical Medicine; Pharmacology
PubMed: 38876496
DOI: 10.1124/pharmrev.124.001017 -
Clinical Pharmacology and Therapeutics Jan 2019Online learning, an essential component of most traditional contact-based educational programs, must be of high quality to contribute effectively to learning. The... (Review)
Review
Online learning, an essential component of most traditional contact-based educational programs, must be of high quality to contribute effectively to learning. The availability of first-class web-based materials is particularly valued by both learners and educators in resource-poor nations. In this Practice article, we introduce the International Union of Basic and Clinical Pharmacology (IUPHAR) Pharmacology Education Project (PEP) (https://www.pharmacologyeducation.org/), a freely accessible online learning resource intended to support education and training in pharmacological sciences worldwide.
Topics: Education, Distance; Humans; Internationality; Pharmacology
PubMed: 30588614
DOI: 10.1002/cpt.1278 -
Journal of Pharmaceutical Sciences Feb 2016
Topics: Humans; Pharmacology; Pharmacy
PubMed: 26869405
DOI: 10.1016/S0022-3549(15)00179-3 -
Clinical Pharmacology and Therapeutics Oct 2021Low- and middle-income countries (LMICs) have the highest rates of mortality and morbidity globally, but lag behind high-income countries in the number of clinical... (Review)
Review
Low- and middle-income countries (LMICs) have the highest rates of mortality and morbidity globally, but lag behind high-income countries in the number of clinical trials and trained researchers, as well as research data pertaining to their populations. Lack of local clinical pharmacology and pharmacometrics expertise, limited training opportunities, and lack of local genomic data may contribute to health inequalities and limit the application of precision medicine. Continuing to develop health care infrastructure, including well-designed clinical pharmacology training and data collection in LMICs, can help address these challenges. International collaboration aimed at improving training and infrastructure and encouraging locally driven research and clinical trials will be of benefit. This review describes several examples where clinical pharmacology expertise could be leveraged, including opportunities for pharmacogenomic expertise that could drive improved recommendations for clinical guidelines. Also described are clinical pharmacology and pharmacometrics training programs in Africa, and the personal experience of a Tanzanian researcher currently on a training sabbatical in the United States, as illustrative examples of how training in clinical pharmacology can be effectively implemented in LMICs. These training efforts will benefit from advocacy for employment opportunities and career development pathways for clinical pharmacologists that are gradually being recognized and developed in LMICs. Clinical pharmacologists have a key role to play in global health, and development of training and research infrastructure to advance this expertise in LMICs will be of tremendous benefit.
Topics: Biomedical Research; Career Choice; Career Mobility; Clinical Trials as Topic; Developing Countries; Global Health; Humans; Pharmacogenetics; Pharmacology, Clinical
PubMed: 33893656
DOI: 10.1002/cpt.2274 -
Journal of Pharmaceutical Sciences Sep 2017
Topics: Chemistry, Pharmaceutical; History, 21st Century; Japan; Pharmacology
PubMed: 28549904
DOI: 10.1016/j.xphs.2017.05.013