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Zeitschrift Fur Medizinische Physik Feb 2023Positron emission tomography is a highly sensitive molecular imaging modality, based on the coincident detection of annihilation photons after positron decay. The most... (Review)
Review
Positron emission tomography is a highly sensitive molecular imaging modality, based on the coincident detection of annihilation photons after positron decay. The most used detector is based on dense, fast, and luminous scintillators read out by light sensors. This review covers the various detector concepts for clinical and preclinical systems.
Topics: Positron-Emission Tomography; Photons
PubMed: 36208967
DOI: 10.1016/j.zemedi.2022.08.004 -
International Review of Neurobiology 2018The hybrid PET/MR scanner represents the first implementation of the effective integration of two modalities allowing truly synchronous/simultaneous acquisition of their... (Review)
Review
The hybrid PET/MR scanner represents the first implementation of the effective integration of two modalities allowing truly synchronous/simultaneous acquisition of their imaging signals. This integration, resulting from the innovation and development of specific hardware components has paved the way for new approaches in the study of neurodegenerative diseases. This chapter will describe the hardware development that has led to the availability of different clinical solutions for PET/MR imaging as well as the still-open technological challenges and opportunities related to the processing and exploitation of the simultaneous acquisition in neurological studies.
Topics: Brain; Humans; Magnetic Resonance Imaging; Multimodal Imaging; Neuroimaging; Positron-Emission Tomography
PubMed: 30314608
DOI: 10.1016/bs.irn.2018.07.026 -
Cardiology Clinics May 2023Systemic vasculitides comprise a group of autoimmune diseases affecting blood vessels. [18F]-fluoro-2-deoxy-d-glucose positron emission tomography/computed tomography... (Review)
Review
Systemic vasculitides comprise a group of autoimmune diseases affecting blood vessels. [18F]-fluoro-2-deoxy-d-glucose positron emission tomography/computed tomography (FDG-PET/CT) plays an important role in the diagnosis and therapeutic monitoring of vasculitides affecting large-sized and medium-sized vessels. FDG-PET/CT also provides complementary information to other vascular imaging tools. The resolution and sensitivity of newer generation scanners continues to increase, hereby improving the ability of FDG-PET/CT to accurately assess the full disease extent in patients with vasculitis. Novel tracers targeting specific immune cells will allow for more detailed detection of vascular infiltrates.
Topics: Humans; Positron Emission Tomography Computed Tomography; Fluorodeoxyglucose F18; Radiopharmaceuticals; Positron-Emission Tomography; Vasculitis
PubMed: 37003681
DOI: 10.1016/j.ccl.2023.01.012 -
Cell Aug 2023Development of radiopharmaceuticals for in vivo positron emission tomography imaging of alpha-synuclein aggregates has the potential to revolutionize Lewy body disease...
Development of radiopharmaceuticals for in vivo positron emission tomography imaging of alpha-synuclein aggregates has the potential to revolutionize Lewy body disease diagnosis and treatment. Reporting in this issue of Cell, Xiang et al. developed a high-affinity positron emission tomography tracer for alpha-synuclein.
Topics: Humans; alpha-Synuclein; Lewy Body Disease; Positron-Emission Tomography; Radiopharmaceuticals
PubMed: 37541192
DOI: 10.1016/j.cell.2023.06.018 -
Methods in Molecular Biology (Clifton,... 2022Positron emission tomography (PET) is a quantitative imaging technique that uses molecules labeled with positron-emitting radionuclides to visualize and measure...
Positron emission tomography (PET) is a quantitative imaging technique that uses molecules labeled with positron-emitting radionuclides to visualize and measure biochemical processes in the tissues of living subjects. In recent years, different PET tracers have been evaluated for their ability to characterize the atherosclerotic process in order to study the activity of the disease. Here, we describe detailed PET methods for preclinical studies of atherosclerosis and summarize the key methodological aspects of PET imaging in clinical studies of atherosclerosis.
Topics: Atherosclerosis; Fluorodeoxyglucose F18; Humans; Positron-Emission Tomography; Radioisotopes; Radiopharmaceuticals
PubMed: 35238004
DOI: 10.1007/978-1-0716-1924-7_50 -
Cancer Jul 2022During the past several decades, numerous studies have provided insights into biological characteristics of cancer cells and identified various hallmarks of cancer... (Review)
Review
During the past several decades, numerous studies have provided insights into biological characteristics of cancer cells and identified various hallmarks of cancer acquired in the tumorigenic processes. However, it is still challenging to image these distinctive traits of cancer to facilitate the management of patients in clinical settings. The rapidly evolving field of positron emission tomography (PET) imaging has provided opportunities to investigate cancer's biological characteristics in vivo. This article reviews the current status of PET imaging on characterizing hallmarks of cancer and discusses the future directions of PET imaging strategies facilitating in vivo cancer phenotyping.
Topics: Humans; Molecular Imaging; Neoplasms; Positron-Emission Tomography
PubMed: 35417604
DOI: 10.1002/cncr.34228 -
Journal of Nuclear Cardiology :... Apr 2022
Topics: Amyloidosis; Humans; Positron Emission Tomography Computed Tomography; Positron-Emission Tomography; Tomography, X-Ray Computed
PubMed: 33502696
DOI: 10.1007/s12350-021-02524-x -
Heart (British Cardiac Society) Nov 2020Positron emission tomography (PET) imaging is useful in cardiovascular disease across several areas, from assessment of myocardial perfusion and viability, to... (Review)
Review
Positron emission tomography (PET) imaging is useful in cardiovascular disease across several areas, from assessment of myocardial perfusion and viability, to highlighting atherosclerotic plaque activity and measuring the extent of cardiac innervation in heart failure. Other important roles of PET have emerged in prosthetic valve endocarditis, implanted device infection, infiltrative cardiomyopathies, aortic stenosis and cardio-oncology. Advances in scanner technology, including hybrid PET/MRI and total body PET imaging, as well as the development of novel PET tracers and cardiac-specific postprocessing techniques using artificial intelligence will undoubtedly continue to progress the field.
Topics: Artificial Intelligence; Cardiovascular Diseases; Humans; Positron-Emission Tomography
PubMed: 32571959
DOI: 10.1136/heartjnl-2019-315183 -
Molecules (Basel, Switzerland) May 2022The use of immunotherapy has revolutionized the treatment regimen of certain cancer types, but response assessment has become a difficult task with conventional methods... (Review)
Review
The use of immunotherapy has revolutionized the treatment regimen of certain cancer types, but response assessment has become a difficult task with conventional methods such as CT/MRT or FDG PET-CT and the classical response criteria such as RECIST or PERCIST which have been developed for chemotherapeutic treatment. Plenty of new tracers have been published to improve the assessment of treatment response and to stratify the patient population. We gathered the information on published tracers (in total, 106 individual SPECT/PET tracers were identified) and performed a descriptor-based analysis; in this way, we classify the tracers with regard to target choice, developability (probability to progress from preclinical stage into the clinic), translatability (probability to be widely applied in the 'real world'), and (assumed) diagnostic quality. In our analysis, we show that most tracers are targeting PD-L1, PD-1, CTLA-4, and CD8 receptors by using antibodies or their fragments. Another finding is that plenty of tracers possess only minor iterations regarding chelators and nuclides instead of approaching the problem in a new innovative way. Based on the data, we suggest an orthogonal approach by targeting intracellular targets with PET-activatable small molecules that are currently underrepresented.
Topics: Humans; Immunotherapy; Neoplasms; Positron Emission Tomography Computed Tomography; Positron-Emission Tomography; Tomography, Emission-Computed, Single-Photon
PubMed: 35630835
DOI: 10.3390/molecules27103354 -
Brain Research Sep 2017The application of positron emission tomography (PET) in brain research has increased substantially during the past 20years, and is still growing. PET provides a unique... (Review)
Review
The application of positron emission tomography (PET) in brain research has increased substantially during the past 20years, and is still growing. PET provides a unique insight into physiological and pathological processes in vivo. In this article we introduce the fundamentals of PET, and the methods available for acquiring quantitative estimates of the parameters of interest. A short introduction to different areas of application is also given, including basic research of brain function and in neurology, psychiatry, drug receptor occupancy studies, and its application in diagnostics of neurodegenerative disorders such as Alzheimer's disease and Parkinson's disease. Our aim is to inform the unfamiliar reader of the underlying basics and potential applications of PET, hoping to inspire the reader into considering how the technique could be of benefit for his or her own research.
Topics: Alzheimer Disease; Animals; Brain; Humans; Neurodegenerative Diseases; Parkinson Disease; Positron-Emission Tomography
PubMed: 28652218
DOI: 10.1016/j.brainres.2017.06.022