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PET Clinics Apr 2016In 2010, the first whole-body PET/MRI scanners installed for clinical use were the sequential Philips PET/MRI with PMT-based, TOF-capable technology and the integrated... (Review)
Review
In 2010, the first whole-body PET/MRI scanners installed for clinical use were the sequential Philips PET/MRI with PMT-based, TOF-capable technology and the integrated simultaneous Siemens PET/MRI. Avalanche photodiodes as non-magneto-sensitive readout electronics allowed PET integrated within the MRI. The experiences with these scanners showed that improvements of software aspects, such as attenuation correction, were necessary and that efficient protocols combining optimally PET and MRI must be still developed. In 2014, General Electric issued an integrated PET/MRI with SiPM-based PET detectors, allowing TOF-PET. Looking at the MRI components of current PET/MR imaging systems, primary improvements come from sequences and new coils.
Topics: Equipment Design; Humans; Magnetic Resonance Imaging; Multimodal Imaging; Positron-Emission Tomography; Whole Body Imaging
PubMed: 26952724
DOI: 10.1016/j.cpet.2015.09.001 -
Annals of Nuclear Medicine Sep 2022Microcalcification, a type of vascular calcification, increases the instability of plaque and easily leads to acute clinical events. Positron emission tomography (PET)... (Review)
Review
Microcalcification, a type of vascular calcification, increases the instability of plaque and easily leads to acute clinical events. Positron emission tomography (PET) is a new examination technology with significant advantages in identifying vascular calcification, especially microcalcification. The use of the F-NaF is undoubtedly the benchmark, and other PET tracers related to vascular calcification are also currently in development. Despite all this, a large number of studies are still needed to further clarify the specific mechanisms and characteristics. This review aimed at providing a summary of the application and progress of different PET tracers and also the future development direction.
Topics: Fluorine Radioisotopes; Humans; Plaque, Atherosclerotic; Positron Emission Tomography Computed Tomography; Positron-Emission Tomography; Radiopharmaceuticals; Sodium Fluoride; Vascular Calcification
PubMed: 35834116
DOI: 10.1007/s12149-022-01771-3 -
Methods in Molecular Biology (Clifton,... 2022Positron emission tomography (PET) is an imaging technology that measures 3D spatial distribution and kinetics of radio-tagged biomolecules in a living subject...
Positron emission tomography (PET) is an imaging technology that measures 3D spatial distribution and kinetics of radio-tagged biomolecules in a living subject quantitatively and nondestructively. Commonly used positron-emitting radionuclides include C, N, and O, which are essential elements for plant growth. Combining radiotracer techniques with PET, this in vivo molecular imaging capability offers plant biologists a powerful tool for molecular phenotyping research. While PET is widely used clinically for cancer diagnosis and pre-clinically for drug development, it is an unfamiliar imaging tool for plant biologists. This chapter introduces the basic principles of PET, factors that affect the quantitative accuracy of PET when imaging plants, and techniques for administering radiotracers to plants for a variety of molecular plant imaging applications.
Topics: Electrons; Positron-Emission Tomography; Radioisotopes
PubMed: 35895200
DOI: 10.1007/978-1-0716-2537-8_11 -
Heart Failure Reviews Sep 2022Cardiac amyloidosis, characterized by progressive restrictive cardiomyopathy, presents unusual diagnostic challenges. Conventional cardiac scintigraphy has shown limited... (Review)
Review
Cardiac amyloidosis, characterized by progressive restrictive cardiomyopathy, presents unusual diagnostic challenges. Conventional cardiac scintigraphy has shown limited utility in the quantification of disease burden and serial follow-up of cardiac amyloidosis. The advent of specialized positron emission tomography with specific amyloid-binding radiotracers has the potential to change currently employed diagnostic algorithms for the imaging of cardiac amyloidosis. This review aims to discuss the diagnostic utility of amyloid-binding radiotracers, including Pittsburg compound B, florbetapir, florbetapan, and sodium fluoride. These tracers have promising potential for the early detection of the particular type of cardiac amyloidosis, pursuing relevant medical intervention, assessing amyloid burden, monitoring treatment response, and overall prognostication.
Topics: Amyloidosis; Heart; Heart Diseases; Humans; Positron-Emission Tomography; Radionuclide Imaging
PubMed: 34743267
DOI: 10.1007/s10741-021-10183-w -
Angewandte Chemie (International Ed. in... Nov 2022The excellent features of non-invasive molecular imaging, its progressive technology (real-time, whole-body imaging and quantification), and global impact by a growing... (Review)
Review
The excellent features of non-invasive molecular imaging, its progressive technology (real-time, whole-body imaging and quantification), and global impact by a growing infrastructure for positron emission tomography (PET) scanners are encouraging prospects to investigate new concepts, which could transform clinical care of complex infectious diseases. Researchers are aiming towards the extension beyond the routinely available radiopharmaceuticals and are looking for more effective tools that interact directly with causative pathogens. We reviewed and critically evaluated (challenges or pitfalls) antibiotic-derived PET radiopharmaceutical development efforts aimed at infection imaging. We considered both radiotracer development for infection imaging and radio-antibiotic PET imaging supplementing other tools for pharmacologic drug characterization; overall, a total of 20 original PET radiotracers derived from eleven approved antibiotics.
Topics: Anti-Bacterial Agents; Positron-Emission Tomography; Radiopharmaceuticals
PubMed: 35834311
DOI: 10.1002/anie.202204955 -
Best Practice & Research. Clinical... Mar 2023The use of fluorodeoxyglucose-positron emission tomography (FDG-PET) imaging to detect vascular inflammation is increasingly common in the clinical management of... (Review)
Review
The use of fluorodeoxyglucose-positron emission tomography (FDG-PET) imaging to detect vascular inflammation is increasingly common in the clinical management of patients with large-vessel vasculitis (LVV). In this review, the role of FDG-PET imaging to diagnose and monitor vascular disease activity will be detailed. Suggestions on incorporation of FDG-PET imaging into a clinical workflow will be provided with emphasis on patient preparation, image acquisition, and image interpretation. If FDG-PET imaging is obtained, multimodal imaging assessment, whereby FDG-PET imaging and non-invasive angiography are obtained concurrently, and correlation of imaging findings with clinical assessment is generally advisable. Considering the clinical scenario and treatment status of the patient is important when interpreting vascular FDG-PET image findings.
Topics: Humans; Fluorodeoxyglucose F18; Positron Emission Tomography Computed Tomography; Workflow; Positron-Emission Tomography; Vasculitis; Molecular Imaging; Giant Cell Arteritis
PubMed: 37516606
DOI: 10.1016/j.berh.2023.101856 -
International Journal of Cardiology Jan 2023
Topics: Humans; Tomography, X-Ray Computed; Positron-Emission Tomography; Heart; Risk Assessment; Positron Emission Tomography Computed Tomography
PubMed: 36179906
DOI: 10.1016/j.ijcard.2022.09.057 -
Medicina (Kaunas, Lithuania) Jul 2018Cardiac positron emission tomography (PET) and positron emission tomography/computed tomography (PET/CT) are encouraging precise non-invasive imaging modalities that... (Review)
Review
Cardiac positron emission tomography (PET) and positron emission tomography/computed tomography (PET/CT) are encouraging precise non-invasive imaging modalities that allow imaging of the cellular function of the heart, while other non-invasive cardiovascular imaging modalities are considered to be techniques for imaging the anatomy, morphology, structure, function and tissue characteristics. The role of cardiac PET has been growing rapidly and providing high diagnostic accuracy of coronary artery disease (CAD). Clinical cardiology has established PET as a criterion for the assessment of myocardial viability and is recommended for the proper management of reduced left ventricle (LV) function and ischemic cardiomyopathy. Hybrid PET/CT imaging has enabled simultaneous integration of the coronary anatomy with myocardial perfusion and metabolism and has improved characterization of dysfunctional areas in chronic CAD. Also, the availability of quantitative myocardial blood flow (MBF) evaluation with various PET perfusion tracers provides additional prognostic information and enhances the diagnostic performance of nuclear imaging.
Topics: Coronary Artery Disease; Heart; Humans; Myocardial Perfusion Imaging; Positron Emission Tomography Computed Tomography; Positron-Emission Tomography; Radiopharmaceuticals
PubMed: 30344278
DOI: 10.3390/medicina54030047 -
PET Clinics Apr 2019PET imaging is a continuously developing clinical tool for the imaging of different markers of cardiovascular diseases. In this article, some important PET tracers for... (Review)
Review
PET imaging is a continuously developing clinical tool for the imaging of different markers of cardiovascular diseases. In this article, some important PET tracers for several diseases affecting the heart and the vessels are highlighted; these include myocardial blood flow, atherosclerosis, fatty acid metabolism, and pathologies in the cardiac autonomic nervous system.
Topics: Autonomic Nervous System Diseases; Cardiovascular Diseases; Coronary Artery Disease; Coronary Circulation; Fatty Acids; Forecasting; Humans; Plaque, Atherosclerotic; Positron-Emission Tomography; Radioisotopes; Radiopharmaceuticals
PubMed: 30826026
DOI: 10.1016/j.cpet.2018.12.010 -
Journal of Labelled Compounds &... Mar 2018The increasing importance of the positron emission tomography (PET) in clinical diagnosis led to the development of a multitude of radiotracers labelled with... (Review)
Review
The increasing importance of the positron emission tomography (PET) in clinical diagnosis led to the development of a multitude of radiotracers labelled with positron-emitting radionuclides of groups 15 (pnicogens) and 16 (chalcogens) of the periodic table of elements. The positron emitters of the endogenous occurring elements nitrogen, phosphorus, oxygen, and sulphur are characterized by very short half-lives compared with the most commonly used PET radionuclides carbon-11 or fluorine-18. Therefore, the potential of their synthesis and possible applications in PET is challenging and limited. On the other hand, the nonstandard positron emitters arsenic-72, arsenic-74, and selenium-73 have half-lives in the range of hours to days and, thus, are of interest for PET studies of processes with long biological half-lives, but novel methods have to be developed for their application, especially in the no-carrier-added state. This review summarizes recent research concerning the positron emitters of pnicogens and chalcogens for radiolabelling applications.
Topics: Electrons; Positron-Emission Tomography; Radioisotopes; Radiopharmaceuticals
PubMed: 29023892
DOI: 10.1002/jlcr.3574