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Nutrients Oct 2019The purpose of this randomized, placebo-controlled, blind study was to investigate the effects of the drinkable nutraceutical ELASTEN (QUIRIS Healthcare, Gütersloh,... (Randomized Controlled Trial)
Randomized Controlled Trial
The purpose of this randomized, placebo-controlled, blind study was to investigate the effects of the drinkable nutraceutical ELASTEN (QUIRIS Healthcare, Gütersloh, Germany) on skin aging and skin health. Drinking ampoules provides a blend of 2.5 g of collagen peptides, acerola fruit extract, vitamin C, zinc, biotin, and a native vitamin E complex. This controlled interventional trial was performed on 72 healthy women aged 35 years or older. They received either the food supplement ( = 36) or a placebo ( = 36) for twelve weeks. A skin assessment was carried out and based on objective validated methods, including corneometry (skin hydration), cutometry (elasticity), the use of silicon skin replicas with optical 3D phase-shift rapid in-vivo measurements (PRIMOS) (roughness), and skin sonography (density). The verum group was followed for an additional four weeks (without intake of the test product) to evaluate the sustainability of the changes induced by the intake of the test product. The test product significantly improved skin hydration, elasticity, roughness, and density. The differences between the verum group and the placebo group were statistically significant for all test parameters. These positive effects were substantially retained during the follow-up. The measured effects were fully consistent with the subjective assessments of the study participants. The nutraceutical was well tolerated.
Topics: Administration, Oral; Adult; Aged; Collagen; Dietary Supplements; Female; Humans; Middle Aged; Skin; Skin Aging; Surveys and Questionnaires
PubMed: 31627309
DOI: 10.3390/nu11102494 -
Journal of Dairy Science Dec 2017Reproductive technology revolutionized dairy production during the past century. Artificial insemination was first successfully applied to cattle in the early 1900s. The... (Review)
Review
Reproductive technology revolutionized dairy production during the past century. Artificial insemination was first successfully applied to cattle in the early 1900s. The next major developments involved semen extenders, invention of the electroejaculator, progeny testing, addition of antibiotics to semen during the 1930s and 1940s, and the major discovery of sperm cryopreservation with glycerol in 1949. The 1950s and 1960s were particularly productive with the development of protocols for the superovulation of cattle with both pregnant mare serum gonadotrophin/equine chorionic gonadotrophin and FSH, the first successful bovine embryo transfer, the discovery of sperm capacitation, the birth of rabbits after in vitro fertilization, and the development of insulated liquid nitrogen tanks. Improved semen extenders and the replacement of glass ampules with plastic semen straws followed. Some of the most noteworthy developments in the 1970s included the initial successes with in vitro culture of embryos, calves born after chromosomal sexing as embryos, embryo splitting resulting in the birth of twins, and development of computer-assisted semen analysis. The 1980s brought flow cytometric separation of X- and Y-bearing sperm, in vitro fertilization leading to the birth of live calves, clones produced by nuclear transfer from embryonic cells, and ovum pick-up via ultrasound-guided follicular aspiration. The 20th century ended with the birth of calves produced from AI with sexed semen, sheep and cattle clones produced by nuclear transfer from adult somatic cell nuclei, and the birth of transgenic cloned calves. The 21st century has seen the introduction of perhaps the most powerful biotechnology since the development of artificial insemination and cryopreservation. Quick, inexpensive genomic analysis via the use of single nucleotide polymorphism genotyping chips is revolutionizing the cattle breeding industry. Now, with the introduction of genome editing technology, the changes are becoming almost too rapid to fully digest.
Topics: Animals; Breeding; Cattle; Dairying; Female; Insemination, Artificial; Male; Pregnancy; Reproductive Techniques; Semen; Sheep
PubMed: 29153167
DOI: 10.3168/jds.2017-13138 -
IUCrData Aug 2023The title compound, digadolinium(III) oxidodisilicate, Gd[SiO], was obtained in its -type crystal structure after attempts to synthesize GdBr[AsO] as a by-product from...
The title compound, digadolinium(III) oxidodisilicate, Gd[SiO], was obtained in its -type crystal structure after attempts to synthesize GdBr[AsO] as a by-product from fused silica ampoules. It crystallizes isotypically with -type Eu[SiO]. This structure consists of layers of ecliptically arranged oxidodisilicate [SiO] units separated from each other by bilayers consisting of Gd cations.
PubMed: 37693777
DOI: 10.1107/S2414314623006545 -
IUCrData Jul 2023The title compound, dicerium(III) oxidodisilicate, Ce[SiO], was obtained as a by-product in its -type structure after attempts to synthesize CeSbOCl from fused silica...
The title compound, dicerium(III) oxidodisilicate, Ce[SiO], was obtained as a by-product in its -type structure after attempts to synthesize CeSbOCl from fused silica ampoules. It crystallizes isotypically with -La[SiO]. The four crystallographically distinct Ce cations form distorted square anti-prisms, capped square anti-prisms, and bicapped square anti-prisms as coordination polyhedra consisting of oxygen atoms. Four crystallographically different silicon atoms recruit the centers of two different isolated [SiO] units.
PubMed: 37937134
DOI: 10.1107/S2414314623005916 -
Applied Radiation and Isotopes :... Oct 2023Lu decays through low-energy β- and γ-emissions in addition to conversion and Auger electrons. To support the use of this radiopharmaceutical in Switzerland, a Lu...
Lu decays through low-energy β- and γ-emissions in addition to conversion and Auger electrons. To support the use of this radiopharmaceutical in Switzerland, a Lu solution was standardised using the β-γ coincidence technique, as well as the TDCR method. The solution had no Lu impurity. Primary coincidence measurements, with plastic scintillators for beta detection, were carried out using both analogue and digital electronics. TDCR measurements using only defocusing were also made. Monte Carlo calculations were used to compute the detection efficiency. The coincidence measurements with both analogue and digital electronics are compatible within one standard uncertainty, but they are lower than (and discrepant with) the TDCR measurements. An ampoule of this solution was submitted to the BIPM as a contribution to the Système International de Référence.
PubMed: 37597267
DOI: 10.1016/j.apradiso.2023.110986 -
JBJS Essential Surgical Techniques Mar 2018Effective anesthesia of the hand and wrist has many uses inside and outside the operating room. In the emergency department or fracture clinic, a wrist block may be used... (Review)
Review
Effective anesthesia of the hand and wrist has many uses inside and outside the operating room. In the emergency department or fracture clinic, a wrist block may be used for closed reductions of dislocations and fractures or for effective inspection and treatment of wounds. In the operating room, surgery may be carried out under a wrist block alone or a wrist block may be used as an adjunct to general anesthesia as the block is an opiate-sparing option to facilitate outpatient surgery and to provide many hours of postoperative analgesia, particularly if administered prior to the commencement of surgery. The landmark technique for distal peripheral nerve blocks at the wrist is a well-recognized method and is described for the median nerve, ulnar nerve, superficial branch of the radial nerve, and dorsal branch of the ulnar nerve at the wrist. To make this technique more effective for carpal surgery, blocks of the posterior interosseous and anterior interosseous nerves are added.Step 1: The patient is counseled about the procedure and the expected outcomes.Step 2: Drug allergies are checked.Step 3: The maximum safe dose of the chosen local anesthetic agent is calculated using the weight of the patient.Step 4: The drug ampules are checked for the name and concentration of the drug as well as the expiration date.Step 5: The drug is drawn up into a 10-mL syringe, and a needle is fitted for injection.Step 6: For each of the 6 nerves to be blocked, the anatomical landmarks are identified along with surrounding structures at risk.Step 7: The skin is prepared with an antiseptic agent.Step 8: The nerve block injections are administered using the techniques in the accompanying video, while checking that there are no signs of intraneural or intravascular injection. The landmark technique for wrist block is an effective method in the situations described above. However, there are occasional failures to provide sufficient analgesia as with all peripheral nerve block techniques. There is a possibility of intraneural injection, which must be avoided. There is also a risk of direct nerve fascicular injury with the needle, which therefore requires a thoughtful technique. There is little if any motor block, which makes the technique particularly suitable when intraoperative active motion is required or when physiotherapy is started directly postoperatively. The technique is very rapid to administer, and it does not require any equipment other than a syringe and needle, making it very inexpensive and suitable for austere environments.
PubMed: 30233979
DOI: 10.2106/JBJS.ST.16.00082 -
Anesthesia, Essays and Researches 2019The frequency of blunders perioperative because of anesthesia is expanding, and the precise occurrence is significantly thought little of practically due to... (Review)
Review
The frequency of blunders perioperative because of anesthesia is expanding, and the precise occurrence is significantly thought little of practically due to underreporting. Root cause analysis of majority of anesthesia errors due to lack of knowledge, unfollow the patient procedures and guidelines, medications errors and lack of communication between the members of anesthesia team leading to morbidity or even mortality. The cornerstone in the operating room environment is the communication, especially the patient's data are accumulated and changed continuously during a patient's anesthesia. Continuous attempts for establishing Iideal strategies to reduce the incidence and chance of anesthesia errors. The advancement of a nonaccuse condition where mistakes are transparently revealed and talked about, and guidelines for naming the medication holders, vials, and ampoules are focused. All endeavors ought to be made in the revealing and anticipation of medical drug errors. It is time to incorporate electronic and digital concepts to encourage the evolution of anesthesia-related drug delivery system.
PubMed: 31198229
DOI: 10.4103/aer.AER_47_19