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American Journal of Transplantation :... Jan 2016While the costs to Medicare of solid organ transplants are varied and considerable, the total Medicare expenditure of $4.2 billion for solid organ transplant recipients...
While the costs to Medicare of solid organ transplants are varied and considerable, the total Medicare expenditure of $4.2 billion for solid organ transplant recipients in 2013 remains less than 1% of all Medicare expenditures. Kidney transplant remains one of the most cost-effective surgical interventions in medicine and exhibits a rare feature in that it is generally known to be cost-saving in the long term. For patients covered by Medicare, lung transplant is one of the more costly solid organ transplants performed. This chapter reports pretransplant costs for lung candidates to allow investigators to further explore the relative cost of lung transplant compared with alternative management.
Topics: Adolescent; Adult; Aged; Child; Child, Preschool; Cost-Benefit Analysis; Health Care Costs; Humans; Infant; Infant, Newborn; Medicare; Middle Aged; Models, Economic; Organ Transplantation; Patient Readmission; United States; Young Adult
PubMed: 26755268
DOI: 10.1111/ajt.13672 -
American Journal of Transplantation :... Aug 2019
Topics: Brain Death; Death; Decision Making; Humans; Organ Transplantation; Tissue Donors; Tissue and Organ Procurement
PubMed: 31343845
DOI: 10.1111/ajt.15510 -
American Journal of Transplantation :... Sep 2017Breast cancer is an important cancer among solid organ transplant recipients. While the incidence of breast cancer in solid organ transplant recipients is comparable to... (Review)
Review
Breast cancer is an important cancer among solid organ transplant recipients. While the incidence of breast cancer in solid organ transplant recipients is comparable to the age-matched general population, the outcomes are generally poor. Interventions such as cancer screening that preclude the development of late-stage disease through early detection are not well studied, and clinical practice guidelines for cancer screening rely solely on recommendations from the general population. Among patients with a prior breast cancer history, disease recurrence after transplantation is a rare but fearful event. Once disease recurs, the risk of death is high. The focus of this review is to present the epidemiology of breast cancer in solid organ transplant recipients, screening and preventive strategies for those who may be at risk, novel genomic profiling for determining tumor progression, and the newer targeted interventions for recipients who have developed breast cancers after solid organ transplantation.
Topics: Breast Neoplasms; Female; Humans; Organ Transplantation; Prognosis
PubMed: 28544474
DOI: 10.1111/ajt.14368 -
American Journal of Transplantation :... Nov 2020The COVID pandemic has impacted solid organ transplantation in unanticipated ways, including organ donation and procurement. Ahmed et al's article is on page 3081.
The COVID pandemic has impacted solid organ transplantation in unanticipated ways, including organ donation and procurement. Ahmed et al's article is on page 3081.
Topics: COVID-19; Humans; Organ Transplantation; Pandemics; SARS-CoV-2; Tissue and Organ Procurement
PubMed: 32761990
DOI: 10.1111/ajt.16235 -
Gastroenterology Clinics of North... Jun 2018Adult intestinal transplantation differs significantly from pediatric intestinal transplantation. While indications have remained largely consistent since 2000,... (Review)
Review
Adult intestinal transplantation differs significantly from pediatric intestinal transplantation. While indications have remained largely consistent since 2000, indications for adults have expanded over the last two decades to include motility disorders and desmoid tumors. Graft type in adult recipients depends on the distinct anatomic characteristics of the adult recipient. Colonic inclusion, while initially speculated to portend unfavorable outcomes due to complex host-bacterial interactions has increased over the past two decades with superior graft survival and improved patient quality of life. Overall, outcomes have steadily improved. For adult intestinal transplant candidates, intestinal transplantation remains a mainstay therapy for complicated intestinal failure and is a promising option for other life threatening and debilitating conditions.
Topics: Adult; Allografts; Donor Selection; Graft Survival; Humans; Intestinal Diseases; Intestines; Organ Transplantation; Patient Selection
PubMed: 29735028
DOI: 10.1016/j.gtc.2018.01.011 -
The Journal of Heart and Lung... Oct 2022
The International Thoracic Organ Transplant Registry of the International Society for Heart and Lung Transplantation: Thirty-ninth adult lung transplantation report-2022; focus on lung transplant recipients with chronic obstructive pulmonary disease.
Topics: Adult; Heart Transplantation; Heart-Lung Transplantation; Humans; Lung; Lung Transplantation; Organ Transplantation; Pulmonary Disease, Chronic Obstructive; Registries; Transplant Recipients
PubMed: 36050206
DOI: 10.1016/j.healun.2022.08.007 -
Xenotransplantation Mar 2023Formal clinical trials of pig-to-human organ transplant-known asxenotransplantation-may begin this decade, with the first trials likely to consist of either adult renal... (Review)
Review
Formal clinical trials of pig-to-human organ transplant-known asxenotransplantation-may begin this decade, with the first trials likely to consist of either adult renal transplants or pediatric cardiac transplant patients. Xenotransplantation as a systematic scientific study only reaches back to the latter half of the 20th century, with episodic xenotransplantation events occurring prior to that. As the science of xenotransplantation has progressed in the 20th and 21st centuries, the public's knowledge of the potential therapy has also increased. With this, there have been shifting ethical stances toward xenotransplantation in key areas, such as religious and public viewpoints towards xenotransplantation, animal rights, and public health concerns. This review provides a historical-ethical account of xenotransplantation and details if or how viewpoints have shifted over time.
Topics: Adult; Humans; Animals; Child; Swine; Transplantation, Heterologous; Organ Transplantation; Heart Transplantation; Kidney Transplantation; Transplants
PubMed: 36943143
DOI: 10.1111/xen.12797 -
Journal of the American College of... Jun 2020
Topics: Air Pollution; Heart Transplantation; Organ Transplantation
PubMed: 32498817
DOI: 10.1016/j.jacc.2020.01.065 -
Acta Haematologica 2020Amyloidosis comprises a diverse group of diseases characterized by misfolding of precursor proteins which eventually form amyloid aggregates and preceding... (Review)
Review
Amyloidosis comprises a diverse group of diseases characterized by misfolding of precursor proteins which eventually form amyloid aggregates and preceding intermediaries, which are deposited in target tissues causing progressive organ damage. In all forms of amyloidosis, vital organs may fail; depending on the specific amyloidosis type, this may occur rapidly or progress slowly. Beyond therapies to reduce the precursor protein (chemotherapy for light chain [AL] amyloidosis, anti-inflammatory therapy in serum A amyloid-osis [AA], and antisense RNA therapy in transthyretin amyloidosis [ATTR]), organ transplantation may also be a means to reduce amyloidogenic protein, e.g., in types of amyloid-osis in which the variant precursor is produced by the liver. Heart transplantation is a life-saving approach to the treatment of patients with advanced cardiac amyloidosis; however, amyloidosis may still be considered a contraindication to the procedure despite data supporting improved outcomes, similar to patients with other indications. Kidney transplantation is associated with particularly favorable outcomes in patients with amyloidosis, especially if the precursor protein has been eliminated. Overall, outcomes of solid organ transplantation are improving, but more data are needed to refine the selection criteria and the timing for organ transplantation, which should be performed in highly experienced centers involving multidisciplinary teams with close patient follow-up to detect amyloid recurrence.
Topics: Amyloidosis; Disease Management; Humans; Immunoglobulin Light-chain Amyloidosis; Organ Transplantation; Treatment Outcome
PubMed: 32535598
DOI: 10.1159/000508262 -
Viruses Oct 2021Solid organ transplant recipients are at increased risk for infections due to chronic immunosuppression. Diarrhea is a commonly encountered problem post transplantation,... (Review)
Review
Solid organ transplant recipients are at increased risk for infections due to chronic immunosuppression. Diarrhea is a commonly encountered problem post transplantation, with infectious causes of diarrhea being a frequent complication. Viral infections/enteritides in solid organ transplant recipients often result from frequently encountered pathogens in this population such as cytomegalovirus, adenovirus, and norovirus. However, several emerging viral pathogens are increasingly being recognized as more sensitive diagnostic techniques become available. Treatment is often limited to supportive care and reduction in immunosuppression, though antiviral therapies mayplay a role in the treatment in certain diseases. Viral enteritis is an important entity that contributes to morbidity and mortality in transplant recipients.
Topics: Adenoviridae; Adenoviridae Infections; Antiviral Agents; Communicable Diseases; Cytomegalovirus; Diarrhea; Enteritis; Humans; Immunocompromised Host; Immunosuppression Therapy; Norovirus; Organ Transplantation; Transplant Recipients; Virus Diseases
PubMed: 34696449
DOI: 10.3390/v13102019