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Chemosphere Feb 2023Per- and polyfluoroalkyl substances (PFAS) are persistent organic pollutants. The first exposure to PFAS occurs in utero, after birth it continues via breast milk, food...
BACKGROUND
Per- and polyfluoroalkyl substances (PFAS) are persistent organic pollutants. The first exposure to PFAS occurs in utero, after birth it continues via breast milk, food intake, environment, and consumer products that contain these chemicals. Our aim was to identify determinants of PFAS concentrations in sensitive population subgroups- pregnant women and newborns.
METHODS
Nine European birth cohorts provided exposure data on PFAS in pregnant women (INMA-Gipuzkoa, Sabadell, Valencia, ELFE and MoBa; total N = 5897) or newborns (3xG study, FLEHS 2, FLEHS 3 and PRENATAL; total N = 940). PFOS, PFOA, PFHxS and PFNA concentrations were measured in maternal or cord blood, depending on the cohort (FLEHS 2 measured only PFOS and PFOA). PFAS concentrations were analysed according to maternal characteristics (age, BMI, parity, previous breastfeeding, smoking, and food consumption during pregnancy) and parental educational level. The association between potential determinants and PFAS concentrations was evaluated using multiple linear regression models.
RESULTS
We observed significant variations in PFAS concentrations among cohorts. Higher PFAS concentrations were associated with higher maternal age, primipara birth, and educational level, both for maternal blood and cord blood. Higher PFAS concentrations in maternal blood were associated with higher consumption of fish and seafood, meat, offal and eggs. In cord blood, higher PFHxS concentrations were associated with daily meat consumption and higher PFNA with offal consumption. Daily milk and dairy consumption were associated with lower concentrations of PFAS in both, pregnant women and newborns.
CONCLUSION
High detection rates of the four most abundant PFAS demonstrate ubiquitous exposure of sensitive populations, which is of concern. This study identified several determinants of PFAS exposure in pregnant women and newborns, including dietary factors, and these findings can be used for proposing measures to reduce PFAS exposure, particularly from dietary sources.
Topics: Animals; Pregnancy; Female; Humans; Vulnerable Populations; Environmental Pollutants; Parity; Diet; Fluorocarbons; Alkanesulfonic Acids
PubMed: 36509187
DOI: 10.1016/j.chemosphere.2022.137530 -
Journal of Dairy Science Feb 2022We investigated the effects of environmental factors on average daily milk yield and day-to-day variation in milk yield of barn-housed Scottish dairy cows milked with an...
We investigated the effects of environmental factors on average daily milk yield and day-to-day variation in milk yield of barn-housed Scottish dairy cows milked with an automated milking system. An incomplete Wood gamma function was fitted to derive parameters describing the milk yield curve including initial milk yield, inclining slope, declining slope, peak milk yield, time of peak, persistency (time in which the cow maintains high yield beyond the peak), and predicted total lactation milk yield (PTLMY). Lactation curves were fitted using generalized linear mixed models incorporating the above parameters (initial milk yield, inclining and declining slopes) and both the indoor and outdoor weather variables (temperature, humidity, and temperature-humidity index) as fixed effects. There was a higher initial milk yield and PTLMY in multiparous cows, but the incline slope parameter and persistency were greatest in primiparous cows. Primiparous cows took 54 d longer to attain a peak yield (mean ± standard error) of 34.25 ± 0.58 kg than multiparous (47.3 ± 0.45 kg); however, multiparous cows yielded 2,209 kg more PTLMY. The best models incorporated 2-d lagged minimum temperature. However, effect of temperature was minimal (primiparous decreased milk yield by 0.006 kg/d and multiparous by 0.001 kg/d for each degree increase in temperature). Both primiparous and multiparous cows significantly decreased in day-to-day variation in milk yield as temperature increased (primiparous cows decreased 0.05 kg/d for every degree increase in 2-d lagged minimum temperature indoors, which was greater than the effect in multiparous cows of 0.008 kg/d). Though the model estimates for both indoor and outdoor were different, a similar pattern of the average daily milk yield and day-to-day variation in milk yield and milk yield's dependence on environmental factors was observed for both primiparous and multiparous cows. In Scotland, primiparous cows were more greatly affected by the 2-d lagged minimum temperature compared with multiparous cows. After peak lactation had been reached, primiparous and multiparous cows decreased milk yield as indoor and outdoor minimum temperature increased.
Topics: Animals; Cattle; Colostrum; Female; Humidity; Lactation; Milk; Parity; Pregnancy
PubMed: 34802739
DOI: 10.3168/jds.2021-20698 -
Asia-Pacific Journal of Public Health Jan 2022This study aimed to analyze the determinants of four or more antenatal care (ANC) visits among working women in Indonesia. The researchers extracted data from the...
This study aimed to analyze the determinants of four or more antenatal care (ANC) visits among working women in Indonesia. The researchers extracted data from the Indonesian Demographic and Health Survey 2017 and obtained a sample size of 8239 working women aged between 15 and 49 years. Women's residence, age, marital status, education level, parity, economic status, and health insurance were selected as the independent variables. Binary logistic regression was used for the analysis. Older working women, married working women, educated working women, those in higher economic status, and those with health insurance were more likely to complete four or more of their ANC visits. The more children the working women had, the less likely they would complete their ANC visits. In conclusion, age, marital status, education, parity, economic status, and health insurance are the determinants for completing ANC visits among working women in Indonesia. At the same time, place of residence does not affect the frequency of ANC visits.
Topics: Adolescent; Adult; Child; Female; Humans; Indonesia; Middle Aged; Parity; Pregnancy; Prenatal Care; Socioeconomic Factors; Women, Working; Young Adult
PubMed: 34670430
DOI: 10.1177/10105395211051237 -
Paediatric and Perinatal Epidemiology Mar 2023Maternal adaptations may vary by foetal sex. Whether male infants influence long-term mortality in mothers remains uncertain.
BACKGROUND
Maternal adaptations may vary by foetal sex. Whether male infants influence long-term mortality in mothers remains uncertain.
OBJECTIVE
The objective of the study was to examine whether male infants increase the risk of maternal mortality.
METHODS
This study included pregnant women enrolled at 12 US sites from 1959 to 1966 in the Collaborative Perinatal Project (CPP). Collaborative Perinatal Project records were linked to the National Death Index and the Social Security Master Death File to ascertain deaths until 2016. Foetal sex was determined by infant sex at birth, defined as the total number of male or female infants in pregnancies prior to or during enrolment in the CPP. In secondary analyses, exposure was defined as infant sex at the last CPP delivery. Outcomes included all-cause and underlying causes of mortality. We used Cox proportional hazards models weighted by the number of prior live births and stratified our models by parity and race/ethnicity.
RESULTS
Among 48,188 women, 50.8% had a male infant at their last registered CPP pregnancy and 39.0% had a recorded death after a mean follow-up of 47.8 years (SD 10.5 years). No linear association was found between the number of liveborn males and all-cause mortality (primipara women: HR 1.02, 95% CI 0.95, 1.09, multipara women, 1 prior live birth: HR 0.96, 95% CI 0.89, 1.03, multipara women, ≥2 prior live births: HR 0.97, 95% CI 0.85, 1.11). A similar trend was noted for cardiovascular- and cancer-related mortality. At the last delivery, women with a male infant did not have an increased risk of all-cause or cause-specific mortality compared to women with a female infant. These findings were consistent across racial/ethnic groups.
CONCLUSIONS
Women who give birth to male infants, regardless of number, are not at increased risk of all-cause and cause-specific mortality. These findings suggest that giving birth to male infants may not independently influence the long-term health of women.
Topics: Humans; Female; Pregnancy; Infant, Newborn; Infant; Adult; Maternal Mortality; Sex Factors; Parity; Mothers
PubMed: 36602298
DOI: 10.1111/ppe.12933 -
International Journal of Environmental... Jan 2023In the context of the global increase in the rate of cesarean deliveries, with an associated higher morbidity and mortality, this study aimed to investigate the role of...
In the context of the global increase in the rate of cesarean deliveries, with an associated higher morbidity and mortality, this study aimed to investigate the role of maternal age and parity in the cesarean section rate among women in the Hail Region of Saudi Arabia. This retrospective cohort study used data collected from the labor ward of the Maternity and Child Health Hospital, Hail, over a period of 8 months, forming a cohort of 500 women. Women were categorized into four different parity classes. The results revealed that there was no significant relationship between cesarean deliveries and maternal age (-value, 0.07). There was no significant difference in the mode of delivery between the study's parity cohort group. A significant increase in cesarean deliveries was noticed among obese women with a BMI between 35-39.9 (52.14%). This increase was even greater among those with a BMI above 40 (63.83%). Fetal distress, malpresentation and abruptio placenta were the most significant indications for CS among all age groups (-value 0.000, 0.021, and 0.048, respectively). Conclusions: The number of cesarean deliveries has no association with parity or age. However, there was a statistically significant association with BMI, a perineal tear after previous vaginal delivery, and a history of diabetes mellitus and gestational diabetes. The most reported reasons for CS were fetal distress, malpresentation, and abruptio placenta among all age groups.
Topics: Child; Pregnancy; Female; Humans; Cesarean Section; Parity; Saudi Arabia; Retrospective Studies; Fetal Distress; Diabetes, Gestational; Labor Presentation
PubMed: 36674239
DOI: 10.3390/ijerph20021486 -
Physiology & Behavior Mar 2019Breeding sows are regularly exposed to on-farm stressors throughout the duration of their production period. The impact of such stressors may differ for primi- and...
Breeding sows are regularly exposed to on-farm stressors throughout the duration of their production period. The impact of such stressors may differ for primi- and multiparous sows, as sows could learn to cope with stressors as they gain experience with them. If parity affects stress in sows, it may also impact their prenatal offspring through differential maternal stress. In addition to parity, litter size is another potential factor involved in stress of sows and piglets. Larger litters may be a source of discomfort for gestating sows, while it can result in intra-uterine growth restriction of piglets. In the current study, we aimed to assess whether parity and litter size affect cortisol measures in breeding sows and their offspring. To do this, we measured salivary cortisol concentrations of 16 primiparous and 16 multiparous sows at three time points: 1) while sows were group housed, 2) after sows were separated from the group prior to moving to the farrowing unit and 3) after handling procedures. In addition, hair cortisol concentration was determined for the sows during late gestation and for their low birth weight (n = 63) and normal birth weight (n = 43) offspring on day 3 after birth, to reflect in-utero cortisol exposure. It was expected that if sows adapt to on-farm stressors, the more experienced, multiparous sows would show decreased stress responses in comparison to primiparous sows. However, we found a comparable acute stress response of primi- and multiparous sows to separation from the group. Handling procedures did not influence sows' salivary cortisol concentrations. Sows' hair cortisol concentration was positively correlated with litter size. Future research is needed to assess whether this finding reflects increased stress in sows carrying larger litters. Parity or litter size did not have a direct effect on their offspring's hair cortisol concentration. Larger litters did have a higher occurrence of low birth weight piglets. For these piglets, females had higher neonatal hair cortisol concentrations than males. Overall, our results indicate that breeding sows do not adapt to all on-farm stressors. In addition, litter size may influence HPA axis activity in both sows and piglets.
Topics: Animals; Birth Weight; Female; Hair; Housing, Animal; Hydrocortisone; Lactation; Litter Size; Male; Parity; Pregnancy; Saliva; Swine
PubMed: 30553897
DOI: 10.1016/j.physbeh.2018.12.014 -
International Journal of Biometeorology Jul 2023Heat stress presents one of the most urgent challenges to modern dairy farming, having major detrimental impacts on cow welfare, health, and production. Understanding...
Heat stress presents one of the most urgent challenges to modern dairy farming, having major detrimental impacts on cow welfare, health, and production. Understanding the effect of cow factors (reproductive status, parity, and lactation stage) on the physiological and behavioural response to hot weather conditions is essential for the accurate detection and practical application of heat mitigation strategies. To study this, collars with commercial accelerometer-based sensors were fitted on 48 lactation dairy cows to record behaviour and heavy breathing from late spring to late summer. The temperature-humidity index (THI) was calculated from measurements of 8 barn sensors. We found that, above a THI of 84, cows in advanced pregnancy (>90 days) spent more time breathing heavily and less time eating and in low activity than other cows, while cows in early pregnancy (≤90 days) spent less time breathing heavily, more time eating and in low activity. Cows with 3+ lactations showed less time breathing heavily and in high activity and more time ruminating and in low activity than cows with fewer lactations. Although lactation stage interacted significantly with THI on time spent breathing heavily, ruminating, eating, and in low activity, there was no clear indication at which lactation stage cows were more sensitive to heat. These findings show that cow factors affect the cow's physiological and behavioural response to heat, which could be used to provide group-specific heat abatement strategies, thereby improving heat stress management.
Topics: Pregnancy; Female; Cattle; Animals; Parity; Hot Temperature; Lactation; Temperature; Humidity; Accelerometry; Milk
PubMed: 37246987
DOI: 10.1007/s00484-023-02496-2 -
Ethiopian Journal of Health Sciences May 2023Increased renal echogenicity is a nonspecific ultrasound finding. It may be a normal variation or suggestive of various underlying conditions like renal amyloidosis,...
BACKGROUND
Increased renal echogenicity is a nonspecific ultrasound finding. It may be a normal variation or suggestive of various underlying conditions like renal amyloidosis, chronic kidney disease, sickle cell disease and HIV associated nephropathy (HIVAN).
OBJECTIVE
To study maternal renal echogenicity in normal pregnancy, and explore its relationship with maternal baseline characteristics in our subregion.
METHODS
This descriptive, cross-sectional study was conducted in the Obstetrics and Radiology Units of the two tertiary health facilities, one secondary facility and one radio-diagnostic facility, all in Bayelsa State, South-South Nigeria, between March-August 2022. The relationships between maternal renal echogenicity and age, parity and gestational age were explored using Chi-square test of proportion, while with an analysis of variance (ANOVA), the mean difference of age, weight and height between the grades of renal echogenicity was investigated. Kruskal Wallis test was deployed to examine parity in the grades of renal echogenicity. The level of significance was set at p<0.05.
RESULTS
The study participants that had Grade 0, 1 and 2 renal echogenicity were 160 (39.7%), 403 (58.3%) and 8 (2.0%), respectively. There were statistically significant relationships between maternal renal echogenicity and maternal age (χ=36.94; p=0.001), parity (χ=64.29; p=0.001), gestational age (χ=16.03; p=0.003) and body mass index (BMI) (χ = 45.15; p - 0.001).
CONCLUSION
Our study revealed a significant relationship between maternal renal echogenicity in normal pregnancy and maternal baseline characteristics (age, parity, gestational age and weight).
Topics: Pregnancy; Humans; Female; Pregnant Women; Birth Weight; Nigeria; Cross-Sectional Studies; Niger; Parity; Ultrasonography; Body Mass Index
PubMed: 37576173
DOI: 10.4314/ejhs.v33i3.10 -
International Journal of Environmental... Jan 2022Despite numerous studies of women having children later in life, evidence of the relationship between maternal factors and newborn outcomes in Central and Eastern...
BACKGROUND
Despite numerous studies of women having children later in life, evidence of the relationship between maternal factors and newborn outcomes in Central and Eastern European countries is limited. This study aimed to examine the association between maternal age, biological determinants, including parity and sex of the newborn, demographic and social background, and birth weight in 3.8 million singleton live births in Poland.
METHODS
The effect of maternal age on birth weight (in grams and Z-scores) adjusted for confounders was assessed using Generalized Linear Models.
RESULTS
The mean (±SD) birth weights of neonates born to primiparous women and multiparous women were 3356.3 ± 524.9 g and 3422.7 ± 538.6 g, respectively, which corresponded to a Z-score of -0.07 ± 0.96 and 0.14 ± 1.00, respectively ( ≤ 0.001). After controlling for biological, demographic, and social factors, a significant decrease in birth weight was found for primiparous women of the age group ≥30 years and multiparous women aged ≥35 years compared to the age group of 25-29 years. The lowest neonatal birth weight was observed in the case of women aged ≥45 years. Confounders did not affect birth weight Z-scores among primiparous women, whereas among multiparous women, together with educational factors, they reversed Z-scores from positive to negative values. The lower birth weight of neonates was overall associated with lower maternal education.
CONCLUSIONS
Regardless of parity, advanced maternal age is strongly associated with a decreased neonatal birth weight, implying complications in early pregnancy and the antenatal period as well as obstetric complications. Counseling to support women's family planning decisions and improving women's education during their reproductive age may help to alleviate unfavorable newborn outcomes.
Topics: Adult; Birth Weight; Child; Female; Humans; Infant, Low Birth Weight; Infant, Newborn; Live Birth; Maternal Age; Middle Aged; Parity; Pregnancy
PubMed: 35162402
DOI: 10.3390/ijerph19031384 -
JAMA Internal Medicine Jul 2022Prior evidence suggests that plasma and platelet transfusions from female and parous donors are associated with adverse clinical outcomes, which has led to the... (Randomized Controlled Trial)
Randomized Controlled Trial
IMPORTANCE
Prior evidence suggests that plasma and platelet transfusions from female and parous donors are associated with adverse clinical outcomes, which has led to the predominant use of male donors for plasma and platelets in many countries. However, studies on red blood cell transfusions have been conflicting.
OBJECTIVE
To determine whether blood donor sex and parity affect mortality of patients undergoing transfusion with red blood cells.
DESIGN, SETTING, AND PARTICIPANTS
This cohort study used nationwide blood bank and health register data in Sweden and involved a natural experiment created by donor sex and parity being concealed and randomly allocated. Patients were included if they were 18 to 90 years old, did not have a history of blood transfusion, and received a transfusion between January 1, 2010, and December 31, 2017. Patients were followed up from their first red blood cell transfusion until death, emigration, or end of study (June 30, 2018). Data analysis was performed between June 15 and December 15, 2021.
EXPOSURES
(1) Female vs male donors and (2) parous or nonparous female vs male donors.
MAIN OUTCOMES AND MEASURES
Overall survival up to 2 years estimated using inverse probability-weighted Kaplan-Meier estimates and relative risk for additional transfusions within 24 hours.
RESULTS
Among the 368 778 included patients (mean [SD] age, 66.3 [17.7] years; 57.3% female), 2-year survival differences comparing red blood cell transfusions from female and parous donors to male donors were -0.1% (95% CI, -1.3% to 1.1%) and 0.3% (95% CI, -0.6% to 1.2%), respectively. No statistically significant survival differences were observed regardless of patient sex or age. Median (IQR) hemoglobin counts for female donors (13.5 [13.0-14.0] g/dL) were lower than for male donors (14.9 [14.4-15.5] g/dL). Red blood cell transfusions from female donors were associated with a relative risk of 1.12 (95% CI, 1.08-1.17) for additional transfusions within 24 hours but not after adjusting for donor hemoglobin counts (relative risk, 1.03; 95% CI, 0.98-1.08). Pretransfusion patient characteristics were naturally distributed as-if randomized.
CONCLUSIONS AND RELEVANCE
In this nationwide cohort study involving a natural experiment, after accounting for the lower hemoglobin values in blood from female donors, patients undergoing transfusion with blood from female or parous donors did not have higher 2-year mortality compared with recipients of blood from male donors.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Blood Transfusion; Cohort Studies; Erythrocyte Transfusion; Female; Hemoglobins; Humans; Male; Middle Aged; Parity; Pregnancy; Young Adult
PubMed: 35696128
DOI: 10.1001/jamainternmed.2022.2115