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Indian Dermatology Online Journal 2024
PubMed: 38283021
DOI: 10.4103/idoj.idoj_490_23 -
Canadian Family Physician Medecin de... Dec 2018To provide family physicians with the information needed to recognize, diagnose, and discuss available treatment options for steatocystoma multiplex (SM). (Review)
Review
OBJECTIVE
To provide family physicians with the information needed to recognize, diagnose, and discuss available treatment options for steatocystoma multiplex (SM).
SOURCES OF INFORMATION
A comprehensive PubMed search using as either a text word or a MeSH term was conducted, and articles reporting on treatment outcomes were included.
MAIN MESSAGE
Steatocystoma multiplex is a benign disorder often characterized by numerous asymptomatic dermal cysts on the trunk, arms, axillae, face, thighs, and scalp. Psychological distress due to these undesirable lesions is not uncommon for this condition. A literature review identified the following SM treatments, all of which were associated with limitations: carbon dioxide laser, modified surgical techniques, cryotherapy, and medical management. Steatocystoma multiplex is challenging to treat and, at this time, effective management is most often achieved through patient education.
CONCLUSION
Family physicians play a critical role in the early diagnosis and management of SM. Education about treatment options and managing patient expectations might greatly alleviate the psychosocial implications of this disease.
Topics: Disease Management; Early Diagnosis; Epidermal Cyst; Female; Humans; Physicians, Family; Steatocystoma Multiplex; Young Adult
PubMed: 30541803
DOI: No ID Found -
International Journal of Trichology 2022Eruptive vellus hair cyst (EVHC) is a rare follicular developmental abnormality of the vellus hair follicles. The usual onset is between 17 and 24 years but may be...
Eruptive vellus hair cyst (EVHC) is a rare follicular developmental abnormality of the vellus hair follicles. The usual onset is between 17 and 24 years but may be congenital. It can arise sporadically or may be inherited in an autosomal dominant fashion. They are caused by an abnormality at the infundibular level of vellus hairs. They usually appear as yellow to reddish-brown papules over the chest, limbs, and abdomen. Histologically, cyst has a stratified squamous epithelium and it contains lamellated keratin and several vellus hairs. We present this rare case of a 12-year-old male because of its unusual morphology and distribution and also to generate awareness about this rarely diagnosed condition. To the best of our knowledge, no case of an axillary variant of EVHC has been reported till date.
PubMed: 35300099
DOI: 10.4103/ijt.ijt_100_20 -
Postepy Dermatologii I Alergologii Feb 2020
PubMed: 32467696
DOI: 10.5114/ada.2018.78999 -
Dermatopathology (Basel, Switzerland) 2018Steatocystoma multiplex is a benign skin disorder originating from the sebaceous and nevoid ducts. Commonly classified under hamartomas, they are distributed over the...
BACKGROUND
Steatocystoma multiplex is a benign skin disorder originating from the sebaceous and nevoid ducts. Commonly classified under hamartomas, they are distributed over the trunk, neck, axillae, and groin.
METHODS
A 28-year-old male patient complained of multiple, asymptomatic skin-colored nodules over the face of 10-year duration. Clinical examination confirmed the historic findings of nontender, polysized, flesh-colored papules and nodules over the said distribution.
RESULTS
On histopathology, a cyst was noted in the mid-dermis, lined by stratified squamous, agranular epithelium, which contained degenerated keratin. Nonpolarized dermoscopy showed a structureless, cream-colored area, and polarized dermoscopy revealed a distinctive, well-circumscribed, yellowish hue which was superimposed over the facial pseudoreticular pigmentary pattern. The findings were compatible with steatocystoma multiplex, and the patient was taken up for radiofrequency ablation.
CONCLUSION
Herein, we report a rare variant of steatocystoma multiplex limited to the face and scalp subjected to dermatoscopy and characteristic histological correlation. To the best of our knowledge and following a literature search, dermoscopic features of this condition have not been reported thus far.
PubMed: 29998099
DOI: 10.1159/000488584 -
KERATIN 17-related recessive atypical pachyonychia congenita with variable hair and tooth anomalies.European Journal of Human Genetics :... Nov 2022We present the first pachyonychia congenita (PC) to involve all ectodermal derivatives and the first recessive KRT17-related PC in total seven members of two...
We present the first pachyonychia congenita (PC) to involve all ectodermal derivatives and the first recessive KRT17-related PC in total seven members of two consanguineous Pakistani families. This atypical PC is characterized by an unusual combination of pachyonychia, plantar keratoderma, folliculitis, alopecia, sparse eyebrows, dental anomalies and variable acanthosis nigricans of neck, dry skin, palmoplantar hyperhidrosis, recurrent blisters on soles and/or arms, rough sparse hair on scalp and keratosis pilaris. By exome sequencing we detected homozygous KRT17 c.281G>A (p.(Arg94His)) in affected individuals, and linkage mapping indicated a single locus. Heterozygous variants in KRT17 cause PC2 (PC-K17) with main characteristics of pachyonychia, subungual keratosis, palmoplantar keratoderma, hyperhidrosis, oral leukokeratosis and epidermal cysts, or steatocystoma multiplex, both with dominant inheritance. The causative variant has been reported in heterozygous state in a family afflicted with severe steatocystoma multiplex and in a sporadic PC2 case, and thus we also define a third phenotype related to the variant. Both exome sequencing and linkage mapping demonstrated recessive inheritance whereas Sanger sequencing indicated heterozygosity for the causal variant, reiterating caution for simple targeted sequencing for genetic testing. Testing parents for variants found in sibs could uncover recessive inheritance also in other KRT genes.
Topics: Humans; Eyebrows; Hyperhidrosis; Keratin-17; Mutation; Nails, Malformed; Pachyonychia Congenita; Steatocystoma Multiplex; Tooth Abnormalities; Pedigree
PubMed: 35676340
DOI: 10.1038/s41431-022-01128-4 -
Imaging Science in Dentistry Dec 2019Steatocystoma multiplex is an uncommon benign skin disease, which typically manifests as numerous intradermal cysts that can be scattered anywhere on the body. Although...
Steatocystoma multiplex is an uncommon benign skin disease, which typically manifests as numerous intradermal cysts that can be scattered anywhere on the body. Although usually asymptomatic, it can be significantly disfiguring. One type of steatocystoma multiplex is known to be associated with the autosomal dominant inheritance of a mutation in the gene coding for keratin 17 (). In such cases, it is often concurrent with other developmental abnormalities of the ectoderm-derived tissues, such as the nails, hair, and teeth. To the best of our knowledge, few cases have been reported of steatocystoma multiplex of the oral and maxillofacial region. This report describes a case of steatocystoma multiplex of both sides of the neck and multiple dental anomalies, with a focus on its clinical, radiological, and histopathological characteristics, as well as the possibility that the patient exhibited the familial type of this condition.
PubMed: 31915618
DOI: 10.5624/isd.2019.49.4.317 -
Indian Journal of Dermatology 2021
PubMed: 35068515
DOI: 10.4103/ijd.IJD_117_20 -
Journal of Cutaneous Medicine and... 2021Hidradenitis suppurativa and steatocystoma multiplex may coexist in the same patient. The overlap of these 2 conditions could be suggestive of an unrecognized defect in...
Hidradenitis suppurativa and steatocystoma multiplex may coexist in the same patient. The overlap of these 2 conditions could be suggestive of an unrecognized defect in follicular proliferation mutual in the pathogenesis of both conditions. Here we present 5 patients with both hidradenitis suppurativa and steatocystoma multiplex. Recognizing the overlap between these 2 conditions is important for accurate diagnosis, management, and identification of potential surgical candidates, as well as future basic science research.
Topics: Adult; Diagnosis, Differential; Female; Hidradenitis Suppurativa; Humans; Male; Steatocystoma Multiplex
PubMed: 33908804
DOI: 10.1177/12034754211010145 -
JAAD Case Reports Aug 2022
PubMed: 35899147
DOI: 10.1016/j.jdcr.2022.06.020