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Marine Drugs Jul 2023The marine-derived hyaluronic acid and other natural biopolymers offer exciting possibilities in the field of biomaterials, providing sustainable and biocompatible... (Review)
Review
The marine-derived hyaluronic acid and other natural biopolymers offer exciting possibilities in the field of biomaterials, providing sustainable and biocompatible alternatives to synthetic materials. Their unique properties and abundance in marine sources make them valuable resources for various biomedical and industrial applications. Due to high biocompatible features and participation in biological processes related to tissue healing, hyaluronic acid has become widely used in tissue engineering applications, especially in the wound healing process. The present review enlightens marine hyaluronan biomaterial providing its sources, extraction process, structures, chemical modifications, biological properties, and biocidal applications, especially for wound healing/dressing purposes. Meanwhile, we point out the future development of wound healing/dressing based on hyaluronan and its composites and potential challenges.
Topics: Hyaluronic Acid; Bandages; Biocompatible Materials; Tissue Engineering; Wound Healing
PubMed: 37623707
DOI: 10.3390/md21080426 -
ACS Biomaterials Science & Engineering Jun 2023Bioprinting as an extension of 3D printing offers capabilities for printing tissues and organs for application in biomedical engineering. Conducting bioprinting in... (Review)
Review
Bioprinting as an extension of 3D printing offers capabilities for printing tissues and organs for application in biomedical engineering. Conducting bioprinting in space, where the gravity is zero, can enable new frontiers in tissue engineering. Fabrication of soft tissues, which usually collapse under their own weight, can be accelerated in microgravity conditions as the external forces are eliminated. Furthermore, human colonization in space can be supported by providing critical needs of life and ecosystems by 3D bioprinting without relying on cargos from Earth, e.g., by development and long-term employment of living engineered filters (such as sea sponges-known as critical for initiating and maintaining an ecosystem). This review covers bioprinting methods in microgravity along with providing an analysis on the process of shipping bioprinters to space and presenting a perspective on the prospects of zero-gravity bioprinting.
Topics: Humans; Regenerative Medicine; Ecosystem; Bioprinting; Weightlessness; Tissue Engineering; Printing, Three-Dimensional
PubMed: 37155968
DOI: 10.1021/acsbiomaterials.3c00195 -
Nature Reviews. Microbiology May 2024Many microorganisms live in the form of a biofilm. Although they are feared in the medical sector, biofilms that are composed of non-pathogenic organisms can be highly... (Review)
Review
Many microorganisms live in the form of a biofilm. Although they are feared in the medical sector, biofilms that are composed of non-pathogenic organisms can be highly beneficial in many applications, including the production of bulk and fine chemicals. Biofilm systems are natural retentostats in which the biocatalysts can adapt and optimize their metabolism to different conditions over time. The adherent nature of biofilms allows them to be used in continuous systems in which the hydraulic retention time is much shorter than the doubling time of the biocatalysts. Moreover, the resilience of organisms growing in biofilms, together with the potential of uncoupling growth from catalytic activity, offers a wide range of opportunities. The ability to work with continuous systems using a potentially self-advancing whole-cell biocatalyst is attracting interest from a range of disciplines, from applied microbiology to materials science and from bioengineering to process engineering. The field of beneficial biofilms is rapidly evolving, with an increasing number of applications being explored, and the surge in demand for sustainable and biobased solutions and processes is accelerating advances in the field. This Review provides an overview of the research topics, challenges, applications and future directions in beneficial and applied biofilm research.
Topics: Biofilms; Bioengineering
PubMed: 37957398
DOI: 10.1038/s41579-023-00985-0 -
ACS Applied Bio Materials Dec 2023Tissue loss and end-stage organ failure are serious health problems across the world. Natural and synthetic polymer scaffold material based artificial organs play an... (Review)
Review
Tissue loss and end-stage organ failure are serious health problems across the world. Natural and synthetic polymer scaffold material based artificial organs play an important role in the field of tissue engineering and organ regeneration, but they are not from the body and may cause side effects such as rejection. In recent years, the biomimetic decellularized scaffold based materials have drawn great attention in the tissue engineering field for their good biocompatibility, easy modification, and excellent organism adaptability. Therefore, in this review, we comprehensively summarize the application of decellularized scaffolds in tissue engineering and biomedicine in recent years. The preparation methods, modification strategies, construction of artificial tissues, and application in biomedical applications are discussed. We hope that this review will provide a useful reference for research on decellularized scaffolds and promote their application tissue engineering.
Topics: Tissue Scaffolds; Tissue Engineering; Regeneration; Biomimetic Materials
PubMed: 38032114
DOI: 10.1021/acsabm.3c00778 -
Biofabrication Nov 2023The three-dimensional (3D) bioprinting technologies are suitable for biomedical applications owing to their ability to manufacture complex and high-precision tissue... (Review)
Review
The three-dimensional (3D) bioprinting technologies are suitable for biomedical applications owing to their ability to manufacture complex and high-precision tissue constructs. However, the slow printing speed of current layer-by-layer (bio)printing modality is the major limitation in biofabrication field. To overcome this issue, volumetric bioprinting (VBP) is developed. VBP changes the layer-wise operation of conventional devices, permitting the creation of geometrically complex, centimeter-scale constructs in tens of seconds. VBP is the next step onward from sequential biofabrication methods, opening new avenues for fast additive manufacturing in the fields of tissue engineering, regenerative medicine, personalized drug testing, and soft robotics, etc. Therefore, this review introduces the printing principles and hardware designs of VBP-based techniques; then focuses on the recent advances in VBP-based (bio)inks and their biomedical applications. Lastly, the current limitations of VBP are discussed together with future direction of research.
Topics: Bioprinting; Tissue Engineering; Regenerative Medicine; Ink; Robotics; Printing, Three-Dimensional; Tissue Scaffolds
PubMed: 37922535
DOI: 10.1088/1758-5090/ad0978 -
Journal of Neural Engineering Jun 2023One of the ultimate goals of neurostimulation field is to design materials, devices and systems that can simultaneously achieve safe, effective and tether-free... (Review)
Review
One of the ultimate goals of neurostimulation field is to design materials, devices and systems that can simultaneously achieve safe, effective and tether-free operation. For that, understanding the working mechanisms and potential applicability of neurostimulation techniques is important to develop noninvasive, enhanced, and multi-modal control of neural activity. Here, we review direct and transduction-based neurostimulation techniques by discussing their interaction mechanisms with neurons via electrical, mechanical, and thermal means. We show how each technique targets modulation of specific ion channels (e.g. voltage-gated, mechanosensitive, heat-sensitive) by exploiting fundamental wave properties (e.g. interference) or engineering nanomaterial-based systems for efficient energy transduction. Overall, our review provides a detailed mechanistic understanding of neurostimulation techniques together with their applications to, and translational studies to guide the researchers toward developing more advanced systems in terms of noninvasiveness, spatiotemporal resolution, and clinical applicability.
Topics: Neurons; Electric Stimulation Therapy; Bioengineering
PubMed: 37224804
DOI: 10.1088/1741-2552/acd870 -
American Journal of Physiology. Cell... Mar 2024
Topics: Bioengineering; Biology
PubMed: 38252506
DOI: 10.1152/ajpcell.00037.2024 -
Biomaterials Jul 2023Aging-associated neurodegenerative diseases, such as Alzheimer's and Parkinson's diseases remain poorly understood and no disease-modifying treatments exist despite... (Review)
Review
Aging-associated neurodegenerative diseases, such as Alzheimer's and Parkinson's diseases remain poorly understood and no disease-modifying treatments exist despite decades of investigation. Predominant in vitro (e.g., 2D cell culture, organoids) and in vivo (e.g., mouse) models of these diseases are insufficient mimics of human brain tissue structure and function and of human neurodegenerative pathobiology, and have thus contributed to this collective translational failure. This has been a longstanding challenge in the field, and new strategies are required to address both fundamental and translational needs. Bioengineered tissue culture models constitute a class of promising alternatives, as they can overcome the low cell density, poor nutrient exchange, and long term culturability limitations of existing in vitro models. Further, they can reconstruct the structural, mechanical, and biochemical cues of native brain tissue, providing a better mimic of human brain tissues for in vitro pathobiological investigation and drug development. We discuss bioengineering techniques for the generation of these neurodegenerative tissue models, including biomaterials-, organoid-, and microfluidics-based approaches, and design considerations for their construction. To aid the development of the next generation of functional neurodegenerative disease models, we discuss approaches to incorporate greater cellular diversity and simulate aging processes within bioengineered brain tissues.
Topics: Animals; Mice; Humans; Neurodegenerative Diseases; Biomedical Engineering; Organoids; Cell Culture Techniques; Bioengineering; Disease Models, Animal
PubMed: 37146365
DOI: 10.1016/j.biomaterials.2023.122143 -
Soft Matter Jun 2023The introduction of surface acoustic waves (SAWs) into lab-on-a-chip microfluidic systems has contributed to the development of a new cutting-edge technology-SAW-based... (Review)
Review
The introduction of surface acoustic waves (SAWs) into lab-on-a-chip microfluidic systems has contributed to the development of a new cutting-edge technology-SAW-based micro/nano manipulation. Recently, the SAW technology has emerged as an important tool for manipulating micro/nano particles/cell populations by virtue of its simplicity, biocompatibility, non-invasiveness, scalability, and versatility. In custom-designed acoustic fields, this technology can be used to manipulate cells, bacteria, exosomes, and even worms precisely, and it has been used in applications such as biomedical and point-of-care diagnostic systems. In this review paper, we start by providing a comprehensive overview of the fundamental working principle and numerical simulation of SAW-based manipulation. Then, we introduce the recent advancements in the manipulation of organisms based on standing and traveling SAWs, including separation, concentration, and transport. At the end of the review, we discuss the current challenges to and future prospects of SAW-based manipulation. The conclusion is that the SAW technology will open up a new frontier in the microfluidics field and contribute significantly to the development of bioengineering research and applications.
Topics: Sound; Acoustics; Microfluidics; Lab-On-A-Chip Devices; Bioengineering
PubMed: 37212436
DOI: 10.1039/d3sm00457k -
International Dental Journal Feb 2024Regenerative dentistry is a rapidly evolving field in dentistry, which has been driven by advancements in biomedical engineering research and the rising treatment... (Review)
Review
Regenerative dentistry is a rapidly evolving field in dentistry, which has been driven by advancements in biomedical engineering research and the rising treatment expectations and demands that exceed the scope of conventional approaches. Tissue engineering, the foundation of regenerative dentistry, mainly focuses on 3 key components: stem cells, bioactive molecules, and scaffolds. Dental tissue-derived stem cells are especially significant in this regard due to their remarkable properties. Regenerative techniques have provided novel approaches to many conventional treatment strategies in various disciplines of dentistry. For instance, regenerative endodontic procedures such as pulp revascularisation have provided an alternative approach to conventional root canal treatment. In addition, conventional surgical and nonsurgical periodontal treatment is being taken over by modified approaches of guided tissue regeneration with the aid of 3-dimensional bioprinting and computer-aided design, which has revolutionised oral and maxillofacial tissue engineering. This review presents a concise overview of the latest treatment strategies that have emerged into clinical practice, potential future technologies, and the role of dental tissue-derived stem cells in regenerative dentistry.
Topics: Humans; Tissue Engineering; Stem Cells; Dental Pulp; Dentistry
PubMed: 37541918
DOI: 10.1016/j.identj.2023.07.008