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Scientific Reports Dec 2023In adults, seeing individual faces is sufficient to trigger dominance evaluations, even when conflict is absent. From early on, infants represent dyadic dominance...
In adults, seeing individual faces is sufficient to trigger dominance evaluations, even when conflict is absent. From early on, infants represent dyadic dominance relations and they can infer conflict outcomes based on a variety of cues. To date, it is unclear if toddlers also make automatic dominance trait evaluations of individual faces. Here we asked if toddlers are sensitive to dominance traits from faces, and whether their sensitivity depends on their face experience. We employed a visual preference paradigm to study 18- and 24-month-old toddlers' sensitivity to dominance traits from three types of faces: artificial, male, female. When presented with artificial faces (Experiment 1), 18- and 24-month-olds attended longer to the non-dominant faces, but only when they were in upright orientation. For real male faces (Experiment 2), toddlers showed equivalent looking durations to the dominant and non-dominant upright faces. However, when looking at female faces (Experiment 3), toddlers displayed a visual preference for the upright non-dominant faces at 24 months. To our knowledge, this is the first study to show that toddlers already display sensitivity to facial cues of dominance from 18 months of age, at least for artificial face stimuli.
Topics: Adult; Infant; Humans; Male; Female; Child, Preschool; Face; Cues
PubMed: 38097711
DOI: 10.1038/s41598-023-49385-7 -
Seminars in Cancer Biology May 2024Cancer cells reprogram their metabolism to become "glycolysis-dominant," which enables them to meet their energy and macromolecule needs and enhancing their rate of... (Review)
Review
Cancer cells reprogram their metabolism to become "glycolysis-dominant," which enables them to meet their energy and macromolecule needs and enhancing their rate of survival. This glycolytic-dominancy is known as the "Warburg effect", a significant factor in the growth and invasion of malignant tumors. Many studies confirmed that members of the GLUT family, specifically HK-II from the HK family play a pivotal role in the Warburg effect, and are closely associated with glucose transportation followed by glucose metabolism in cancer cells. Overexpression of GLUTs and HK-II correlates with aggressive tumor behaviour and tumor microenvironment making them attractive therapeutic targets. Several studies have proven that the regulation of GLUTs and HK-II expression improves the treatment outcome for various tumors. Therefore, small molecule inhibitors targeting GLUT and HK-II show promise in sensitizing cancer cells to treatment, either alone or in combination with existing therapies including chemotherapy, radiotherapy, immunotherapy, and photodynamic therapy. Despite existing therapies, viable methods to target the glycolysis of cancer cells are currently lacking to increase the effectiveness of cancer treatment. This review explores the current understanding of GLUT and HK-II in cancer metabolism, recent inhibitor developments, and strategies for future drug development, offering insights into improving cancer treatment efficacy.
Topics: Humans; Neoplasms; Glycolysis; Glucose; Tumor Microenvironment
PubMed: 38494080
DOI: 10.1016/j.semcancer.2024.03.001 -
Philosophical Transactions of the Royal... Aug 2023Continuing the centuries-long exchange between economics and biology, our model of reproductive skew is an adaptation of the principal-agent relationship between an...
Continuing the centuries-long exchange between economics and biology, our model of reproductive skew is an adaptation of the principal-agent relationship between an employer and an employee. Inspired by the case of purple martins () and lazuli buntings (), we model a dominant male whose fitness can be advanced not only by coercing a subordinate male but, where coercion is impossible or not cost-effective, also by providing positive fitness incentives for the subordinate that induce him to behave in ways that contribute to the dominant's fitness. We model a situation in which a dominant and subordinate contest over a variable amount of joint total fitness, both the level and division of which result from the strategies adopted by both. Thus there is not some given amount of potential fitness (or 'pie') that is to be divided between the two (or wasted in costly contests). The fitness incentives that in evolutionary equilibrium are conceded to the subordinate by the dominant maximize the dominant's own fitness. The reason is that the larger pie resulting from the subordinate's increased helping more than compensates for the dominant's reduced fitness share. But the conflict over fitness shares nonetheless limits the size of the pie. This article is part of the theme issue 'Evolutionary ecology of inequality'.
Topics: Male; Humans; Acclimatization; Biological Evolution; Coercion; Ecology; Employment
PubMed: 37381848
DOI: 10.1098/rstb.2022.0289 -
Marine Environmental Research Nov 2023As a consequence of the increasing human footprint on the environment, marine ecosystems are rapidly transforming into new configurations dominated by early-successional...
As a consequence of the increasing human footprint on the environment, marine ecosystems are rapidly transforming into new configurations dominated by early-successional and weedy life forms. Algal turfs, in particular, are emerging as a common and widespread configuration of shallow temperate and tropical reefs, and are predicted to transform reef dynamics and ecosystem services. Restoration is an increasingly used approach to mitigate these transformations, with turf removal being proposed as a tool to shift back the competitive balance and facilitate the recovery of initial species, such as forest-forming seaweeds. Yet, our practical understanding of turf recovery trajectories following removal is limited, and removal success may be hindered by strong feedback mechanisms that reinforce turf dominance once turfs are established. Here we investigate the recovery of algal turfs and their properties (mean height, turf biomass and sediment load) to experimental clearance across six turf-dominated reefs at ca. 9 m in subtropical western Australia. Turf cover, mean height, and sediment loads exhibited a rapid recovery following experimental clearing, with all experimental sites reaching pre-clearing turf conditions between 28 and 46 days. This response was mostly driven by the growth of filamentous turf species, whose cover exhibited a positive relationship with sediment load, and are well-known to rapidly recover after disturbance. Turf abundance and turf properties remained relatively constant for the remaining experimental period. Our results suggest that clearing turfs creates only a small time window for recovery of seaweed forests, which limits the effectiveness of turf clearing as a restoration tool. System-specific quantitative evidence on the recovery capacity of turfs may thus be necessary to guide restoration initiatives and develop decision support systems that account for the risks, feasibility, and costs and benefits of restoring turf-dominated systems to previous configurations.
Topics: Humans; Animals; Ecosystem; Geologic Sediments; Forests; Biomass; Seaweed; Coral Reefs; Anthozoa
PubMed: 37797426
DOI: 10.1016/j.marenvres.2023.106185 -
Bioethics May 2024Cryonics is the practice of cryopreserving the bodies or brains of legally dead individuals with the hope that these individuals will be reanimated in the future. A...
Cryonics is the practice of cryopreserving the bodies or brains of legally dead individuals with the hope that these individuals will be reanimated in the future. A standard argument for cryonics says that cryonics is prudentially justified despite uncertainty about its success because at worst it will leave you no worse off than you otherwise would have been had you not chosen cryonics, and at best it will leave you much better off than you otherwise would have been. Thus, it is a good, no-risk bet; in game-theoretic terms, cryonics is a weakly dominant strategy relative to refraining from utilizing cryonics. I object to this argument for two reasons. First, I argue that there is a practically relevant chance that cryonics will put you into an inescapable and very bad situation. Hence, cryonics is neither a no-risk bet nor a weakly dominant strategy. Second, I argue that the experience of being reanimated and living in the distant future would likely be transformative, and this likelihood undermines your justification for thinking that reanimation would be beneficial to you. I conclude that the standard argument does not show that cryonics is prudentially justified.
Topics: Humans; Cryopreservation; Brain; Uncertainty
PubMed: 38425091
DOI: 10.1111/bioe.13277 -
Genome Biology Sep 2023Dominance and other non-additive genetic effects arise from the interaction between alleles, and historically these phenomena play a major role in quantitative genetics....
BACKGROUND
Dominance and other non-additive genetic effects arise from the interaction between alleles, and historically these phenomena play a major role in quantitative genetics. However, most genome-wide association studies (GWAS) assume alleles act additively.
RESULTS
We systematically investigate both dominance-here representing any non-additive within-locus interaction-and additivity across 574 physiological and gene expression traits in three mammalian stocks: F2 intercross pigs, rat heterogeneous stock, and mice heterogeneous stock. Dominance accounts for about one quarter of heritable variance across all physiological traits in all species. Hematological and immunological traits exhibit the highest dominance variance, possibly reflecting balancing selection in response to pathogens. Although most quantitative trait loci (QTLs) are detectable as additive QTLs, we identify 154, 64, and 62 novel dominance QTLs in pigs, rats, and mice respectively that are undetectable as additive QTLs. Similarly, even though most cis-acting expression QTLs are additive, gene expression exhibits a large fraction of dominance variance, and trans-acting eQTLs are enriched for dominance. Genes causal for dominance physiological QTLs are less likely to be physically linked to their QTLs but instead act via trans-acting dominance eQTLs. In addition, thousands of eQTLs are associated with alternatively spliced isoforms with complex additive and dominant architectures in heterogeneous stock rats, suggesting a possible mechanism for dominance.
CONCLUSIONS
Although heritability is predominantly additive, many mammalian genetic effects are dominant and likely arise through distinct mechanisms. It is therefore advantageous to consider both additive and dominance effects in GWAS to improve power and uncover causality.
Topics: Mice; Rats; Animals; Swine; Alternative Splicing; Genome-Wide Association Study; Quantitative Trait Loci; Mammals; Gene Expression
PubMed: 37773188
DOI: 10.1186/s13059-023-03060-2 -
Trends in Plant Science Jan 2024In diploid organisms, haploinsufficiency can be defined as the requirement for more than one fully functional copy of a gene. In contrast to most genes, whose... (Review)
Review
In diploid organisms, haploinsufficiency can be defined as the requirement for more than one fully functional copy of a gene. In contrast to most genes, whose loss-of-function alleles are recessive, loss-of-function alleles of haploinsufficient genes are dominant. However, forward and reverse genetic screens are biased toward obtaining recessive, loss-of-function mutations, and therefore, dominant mutations of all types are underrepresented in mutant collections. Despite this underrepresentation, haploinsufficient loci have intriguing implications for studies of genome evolution, gene dosage, stability of protein complexes, genetic redundancy, and gene expression. Here we review examples of haploinsufficiency in flowering plants and describe the underlying molecular mechanisms and evolutionary forces driving haploinsufficiency. Finally, we discuss the masking of haploinsufficiency by genetic redundancy, a widespread phenomenon among angiosperms.
Topics: Haploinsufficiency; Magnoliopsida; Gene Dosage; Mutation
PubMed: 37633803
DOI: 10.1016/j.tplants.2023.07.009 -
Cureus Oct 2023In binocular vision, there is a dominant eye and a nondominant eye, a phenomenon termed ocular dominance. This study determined the differences and associations of the...
PURPOSE
In binocular vision, there is a dominant eye and a nondominant eye, a phenomenon termed ocular dominance. This study determined the differences and associations of the ocular blood flow parameters between dominant and nondominant eyes in healthy Japanese subjects.
METHODS
This cross-sectional study included 128 eyes of 64 subjects (13 male and 51 female) aged ≥ 20 years. The ocular blood flow parameters were assessed using laser speckle flowgraphy (LSFG), and software was used to calculate the mean blur rate (MBR), which reflects the blood flow velocity.
RESULTS
There were no significant differences in axial length (AL), spherical equivalent (SE), intraocular pressure (IOP), uncorrected visual acuity (UCVA), best-corrected visual acuity (BCVA), or ocular blood flow parameters between the dominant and nondominant eyes. The ocular blood flow parameters of the dominant eye were significantly and positively correlated with those of the nondominant eye (all P < 0.001).
CONCLUSIONS
No significant differences in ocular blood flow parameters exist between the dominant and nondominant eyes in healthy subjects. The ocular blood flow parameters in the dominant eye are associated with those in the nondominant eye.
PubMed: 37927688
DOI: 10.7759/cureus.46500 -
Parasitology Research Jan 2024Marsupials, inhabiting diverse ecosystems, including urban and peri-urban regions in Australasia and the Americas, intersect with human activities, leading to zoonotic... (Review)
Review
Marsupials, inhabiting diverse ecosystems, including urban and peri-urban regions in Australasia and the Americas, intersect with human activities, leading to zoonotic spill-over and anthroponotic spill-back of pathogens, including Cryptosporidium and Giardia. This review assesses the current knowledge on the diversity of Cryptosporidium and Giardia species in marsupials, focusing on the potential zoonotic risks. Cryptosporidium fayeri and C. macropodum are the dominant species in marsupials, while in possums, the host-specific possum genotype dominates. Of these three species/genotypes, only C. fayeri has been identified in two humans and the zoonotic risk is considered low. Generally, oocyst shedding in marsupials is low, further supporting a low transmission risk. However, there is some evidence of spill-back of C. hominis into kangaroo populations, which requires continued monitoring. Although C. hominis does not appear to be established in small marsupials like possums, comprehensive screening and analysis are essential for a better understanding of the prevalence and potential establishment of zoonotic Cryptosporidium species in small marsupials. Both host-specific and zoonotic Giardia species have been identified in marsupials. The dominance of zoonotic G. duodenalis assemblages A and B in marsupials may result from spill-back from livestock and humans and it is not yet understood if these are transient or established infections. Future studies using multilocus typing tools and whole-genome sequencing are required for a better understanding of the zoonotic risk from Giardia infections in marsupials. Moreover, much more extensive screening of a wider range of marsupial species, particularly in peri-urban areas, is required to provide a clearer understanding of the zoonotic risk of Cryptosporidium and Giardia in marsupials.
Topics: Humans; Animals; Giardia; Giardiasis; Cryptosporidium; Cryptosporidiosis; Ecosystem; Macropodidae
PubMed: 38253768
DOI: 10.1007/s00436-024-08129-w -
Medical Education Jan 2024Health professions education (HPE) must keep pace with rapid shifts in learning and societal contexts, control of resources, knowledge and environmental concerns.... (Review)
Review
BACKGROUND
Health professions education (HPE) must keep pace with rapid shifts in learning and societal contexts, control of resources, knowledge and environmental concerns. Sustainability is increasingly seen as complex, balancing the three pillars of economy, society and the environment and addressing the current generation's needs without compromising future generations' needs. We aim to orient three-pillar sustainability in (HPE) from a decolonial global perspective.
CONFERENCES AS TRUTH-REGIMES
Future-proofing imperatives compel HPE to respond to sustainability calls in contexts of globalisation and internationalisation. International conferences are sites of power in knowledge production and dissemination because themes and invited speakers determine who experts in the field are and what knowledge is important. Scholarly communities, dominating the discourse, determine the nature of reality or 'truth' (ontology), theoretical foundations of that reality and approaches to knowing (epistemology). Using one international conference as a case study, we found few scholarly presentations on sustainability, especially economic disparities. Discourse in HPE is still dominated by Global North 'experts'.
IMPLICATIONS
Conferences are important discursive spaces for knowledge production and exchange. Increasing attention to social justice and planetary health must include a global perspective on three-pillar sustainability. Historical and contemporary perspectives about disparities on health should exceed Eurocentric epistemologies alone. These are areas ripe for innovative research in HPE. Promisingly, there is increasing attention to curricula around health equity, disparities and clinical rotations in rural and underserved communities among educational institutions around the world.
CONCLUSIONS
Future-proofing HPE requires addressing three sustainability pillars simultaneously. Conferences as influential knowledge production spaces are mostly characterised by Global North to South flow of knowledge. Global North-dominated discourse fails to reflect on the impact of historical disparities including colonialism that thwart equivalence. Transforming HPE can occur through a sustainability perspective that advances three-pillar global approaches for inclusive global legitimacy in HPE narratives and standards.
Topics: Humans; Curriculum; Learning; Internationality; Social Justice; Health Occupations
PubMed: 37350281
DOI: 10.1111/medu.15149