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Nature Reviews. Microbiology Oct 2023The development of antiretroviral therapy for the prevention and treatment of HIV infection has been marked by a series of remarkable successes. However, the efforts to... (Review)
Review
The development of antiretroviral therapy for the prevention and treatment of HIV infection has been marked by a series of remarkable successes. However, the efforts to develop a vaccine have largely failed, and efforts to discover a cure are only now beginning to gain traction. In this Review, we describe recent progress on all fronts - pre-exposure prophylaxis, vaccines, treatment and cure - and we discuss the unmet needs, both current and in the coming years. We describe the emerging arsenal of drugs, biologics and strategies that will hopefully address these needs. Although HIV research has largely been siloed in the past, this is changing, as the emerging research agenda is marked by multiple cross-discipline synergies and collaborations. As the limitations of antiretroviral drugs as a means to truly end the epidemic are becoming more apparent, there is a great need for continued efforts to develop an effective preventative vaccine and a scalable cure, both of which remain formidable challenges.
Topics: Humans; HIV Infections
PubMed: 37344551
DOI: 10.1038/s41579-023-00914-1 -
Science (New York, N.Y.) Aug 2023Over the past 30 weeks, Israel has been undergoing an upheaval marked by unprecedented attacks by the government on the independence of its judiciary, attorney general,...
Over the past 30 weeks, Israel has been undergoing an upheaval marked by unprecedented attacks by the government on the independence of its judiciary, attorney general, government legal advisers, police, military, public broadcasting, and religious freedom. This assault on democratic institutions and principles is an imminent threat to Israeli academia, which relies on a solid democratic foundation. In response, universities, academics, and students have emerged as key proponents of ongoing protests under the banner, "No democracy, no academia."
PubMed: 37590362
DOI: 10.1126/science.adk3054