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International Journal of Molecular... Mar 2024Molecular biology has always represented an enviable tool in the fields of biosciences, diagnostics, and forensic sciences [...].
Molecular biology has always represented an enviable tool in the fields of biosciences, diagnostics, and forensic sciences [...].
Topics: Forensic Sciences; Molecular Biology
PubMed: 38474130
DOI: 10.3390/ijms25052883 -
Viruses Jul 2023Despite the availability of effective anti-HIV drug therapy, according to UNAIDS estimates, 1 [...].
Despite the availability of effective anti-HIV drug therapy, according to UNAIDS estimates, 1 [...].
Topics: Humans; HIV Infections; Retroviridae; Anti-HIV Agents; Molecular Biology
PubMed: 37515235
DOI: 10.3390/v15071549 -
Chemical Biology & Drug Design Jun 2024The utilization of large language models (LLMs) has become a significant advancement in the domains of medicine and clinical informatics, providing a revolutionary... (Review)
Review
The utilization of large language models (LLMs) has become a significant advancement in the domains of medicine and clinical informatics, providing a revolutionary potential for scientific breakthroughs and customized therapies. LLM models are trained on large datasets and exhibit the capacity to comprehend and analyze intricate biological data, encompassing genomic sequences, protein structures, and clinical health records. With the utilization of their comprehension of the language of biology, they possess the ability to reveal concealed patterns and insights that may evade human researchers. LLMs have been shown to positively impact various aspects of molecular biology, including the following: genomic analysis, drug development, precision medicine, biomarker development, experimental design, collaborative research, and accessibility to specialized expertise. However, it is imperative to acknowledge and tackle the obstacles and ethical implications involved. The careful consideration of data bias and generalization, data privacy and security, explainability and interpretability, and ethical concerns around responsible application is vital. The successful resolution of these obstacles will enable us to fully utilize the capabilities of LLMs, leading to substantial progress in the fields of molecular biology and pharmaceutical research. This progression also has the ability to bolster influential impacts for both the individual and the broader community.
Topics: Humans; Drug Development; Molecular Biology
PubMed: 38898381
DOI: 10.1111/cbdd.14568 -
Cell Feb 2024Continuing the celebration of Cell's 50th anniversary, this Focus Issue is an ode to the field of Structural Biology. We present Leading Edge articles highlighting...
Continuing the celebration of Cell's 50th anniversary, this Focus Issue is an ode to the field of Structural Biology. We present Leading Edge articles highlighting specific approaches and insights that this field offers to answer fundamental and critical biological questions.
Topics: Molecular Biology; Cell Biology; Microscopy, Electron; Periodicals as Topic
PubMed: 38306976
DOI: 10.1016/j.cell.2024.01.006 -
Cold Spring Harbor Perspectives in... Nov 2023Retinitis pigmentosa GTPase regulator () gene variants are the predominant cause of X-linked retinitis pigmentosa (XLRP) and a common cause of cone-rod dystrophy (CORD).... (Review)
Review
Retinitis pigmentosa GTPase regulator () gene variants are the predominant cause of X-linked retinitis pigmentosa (XLRP) and a common cause of cone-rod dystrophy (CORD). XLRP presents as early as the first decade of life, with impaired night vision and constriction of peripheral visual field and rapid progression, eventually leading to blindness. In this review, we present gene structure and function, molecular genetics, animal models, -associated phenotypes and highlight emerging potential treatments such as gene-replacement therapy.
Topics: Animals; Mutation; Eye Proteins; Retinitis Pigmentosa; Molecular Biology
PubMed: 37188525
DOI: 10.1101/cshperspect.a041280 -
Advanced Drug Delivery Reviews Oct 2023Ocular surface neovascularization and its resulting pathological changes significantly alter corneal refraction and obstruct the light path to the retina, and hence is a... (Review)
Review
Ocular surface neovascularization and its resulting pathological changes significantly alter corneal refraction and obstruct the light path to the retina, and hence is a major cause of vision loss. Various factors such as infection, irritation, trauma, dry eye, and ocular surface surgery trigger neovascularization via angiogenesis and lymphangiogenesis dependent on VEGF-related and alternative mechanisms. Recent advances in antiangiogenic drugs, nanotechnology, gene therapy, surgical equipment and techniques, animal models, and drug delivery strategies have provided a range of novel therapeutic options for the treatment of ocular surface neovascularization. In this review article, we comprehensively discuss the etiology and mechanisms of corneal neovascularization and other types of ocular surface neovascularization, as well as emerging animal models and drug delivery strategies that facilitate its management.
Topics: Animals; Molecular Medicine; Neovascularization, Pathologic; Corneal Neovascularization; Retina; Angiogenesis Inhibitors
PubMed: 37689278
DOI: 10.1016/j.addr.2023.115084 -
Experimental Eye Research Sep 2023Anterior segment dysgenesis is a severe developmental eye disorder that leads to blindness in children. The exact mechanisms underlying this condition remain elusive.... (Review)
Review
Anterior segment dysgenesis is a severe developmental eye disorder that leads to blindness in children. The exact mechanisms underlying this condition remain elusive. Recently, an increasing amount of studies have focused on genes and signal transduction pathways that affect anterior segment dysgenesis;these factors include transcription factors, developmental regulators, extracellular matrix genes, membrane-related proteins, cytoskeleton proteins and other associated genes. To date, dozens of gene variants have been found to cause anterior segment dysgenesis. However, there is still a lack of effective treatments. With a broader and deeper understanding of the molecular mechanisms underlying anterior segment development in the future, gene editing technology and stem cell technology may be new treatments for anterior segment dysgenesis. Further studies on the mechanisms of how different genes influence the onset and progression of anterior segment dysgenesis are still needed.
Topics: Child; Humans; Anterior Eye Segment; Eye Abnormalities; Transcription Factors; Molecular Biology
PubMed: 37495069
DOI: 10.1016/j.exer.2023.109603 -
International Journal of Molecular... Jun 2024In recent years, as biotechnological advancements have continued to unfold, our understanding of plant molecular biology has undergone a remarkable transformation [...].
In recent years, as biotechnological advancements have continued to unfold, our understanding of plant molecular biology has undergone a remarkable transformation [...].
Topics: Plants; Molecular Biology; Biotechnology
PubMed: 38928115
DOI: 10.3390/ijms25126408 -
The Journal of General Virology May 2024Since its discovery in 1965, our understanding of the hepatitis B virus (HBV) replication cycle and host immune responses has increased markedly. In contrast, our... (Review)
Review
Since its discovery in 1965, our understanding of the hepatitis B virus (HBV) replication cycle and host immune responses has increased markedly. In contrast, our knowledge of the molecular biology of hepatitis delta virus (HDV), which is associated with more severe liver disease, is less well understood. Despite the progress made, critical gaps remain in our knowledge of HBV and HDV replication and the mechanisms underlying viral persistence and evasion of host immunity. The International HBV Meeting is the leading annual scientific meeting for presenting the latest advances in HBV and HDV molecular virology, immunology, and epidemiology. In 2023, the annual scientific meeting was held in Kobe, Japan and this review summarises some of the advances presented at the Meeting and lists gaps in our knowledge that may facilitate the development of new therapies.
Topics: Hepatitis B virus; Humans; Virus Replication; Hepatitis Delta Virus; Hepatitis B; Molecular Biology; Japan; Hepatitis D; Host-Pathogen Interactions
PubMed: 38757942
DOI: 10.1099/jgv.0.001978 -
Molecular Cell Sep 2023Molecular Cell has a conversation with Martin Farley about LEAF, the program he developed to run molecular biology laboratories in a sustainable way; the obstacles to...
Molecular Cell has a conversation with Martin Farley about LEAF, the program he developed to run molecular biology laboratories in a sustainable way; the obstacles to making molecular biology sustainable; programs available to scientists; and caution to be exercised when taking steps towards sustainability.
Topics: Male; Humans; Laboratories; Molecular Biology
PubMed: 37738956
DOI: 10.1016/j.molcel.2023.08.012