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Clinical Case Reports Jun 2024Myroides odoratus infection, a rare gram-negative bacillus, predominantly affects immunocompromised patients and presents with diverse clinical manifestations....
Myroides odoratus infection, a rare gram-negative bacillus, predominantly affects immunocompromised patients and presents with diverse clinical manifestations. Antibiotic resistance poses challenges in determining appropriate treatment. This case underscores successful management of Myroides odoratus cellulitis complicated by bacteremia with dual antibiotic therapy, emphasizing the importance of timely recognition and susceptibility testing for effective treatment strategies.
PubMed: 38887306
DOI: 10.1002/ccr3.9090 -
The Science of the Total Environment Jun 2024Hermetia illucens larvae can enhance the degradation of oxytetracycline (OTC) through its biotransformation. However, the underlying mechanisms mediated by gut...
Hermetia illucens larvae can enhance the degradation of oxytetracycline (OTC) through its biotransformation. However, the underlying mechanisms mediated by gut metabolites and proteins are unclear. To gain further insights, the kinetics of OTC degradation, the functional structures of gut bacterial communities, proteins, and metabolites were investigated. An availability-adjusted first-order model effectively evaluated OTC degradation kinetics, with degradation half-lives of 4.18 and 21.71 days for OTC degradation with and without larval biotransformation, respectively. Dominant bacteria in the larval guts were Enterococcus, Psychrobacter, Providencia, Myroides, Enterobacteriaceae, and Lactobacillales. OTC exposure led to significant differential expression of proteins, with functional classification revealing involvement in digestion, transformation, and adaptability to environmental stress. Upregulated proteins, such as aromatic ring hydroxylase, acted as oxidoreductases modifying the chemical structure of OTC. Unique metabolites, aclarubicin and sancycline identified were possible OTC metabolic intermediates. Correlation analysis revealed significant interdependence between gut bacteria, metabolites, and proteins. These findings reveal a synergistic mechanism involving gut microbial metabolism and enzyme structure that drives the rapid degradation of OTC and facilitates the engineering applications of bioremediation.
PubMed: 38914334
DOI: 10.1016/j.scitotenv.2024.174224