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Cells Jul 2023Depression is a common neuropsychiatric disorder with long-term recurrent depressed mood, pain and despair, pessimism and anxiety, and even suicidal tendencies as the... (Review)
Review
Depression is a common neuropsychiatric disorder with long-term recurrent depressed mood, pain and despair, pessimism and anxiety, and even suicidal tendencies as the main symptoms. Depression usually induces or aggravates the development of other related diseases, such as sleep disorders and endocrine disorders. In today's society, the incidence of depression is increasing worldwide, and its pathogenesis is complex and generally believed to be related to genetic, psychological, environmental, and biological factors. Current studies have shown the key role of glial cells in the development of depression, and it is noteworthy that some recent evidence suggests that the development of depression may be closely related to viral infections, such as SARS-CoV-2, BoDV-1, ZIKV, HIV, and HHV6, which infect the organism and cause some degree of glial cells, such as astrocytes, oligodendrocytes, and microglia. This can affect the transmission of related proteins, neurotransmitters, and cytokines, which in turn leads to neuroinflammation and depression. Based on the close relationship between viruses and depression, this paper provides an in-depth analysis of the new mechanism of virus-induced depression, which is expected to provide a new perspective on the mechanism of depression and a new idea for the diagnosis of depression in the future.
Topics: Humans; Depression; Zika Virus Infection; COVID-19; SARS-CoV-2; Zika Virus; Neurons
PubMed: 37443801
DOI: 10.3390/cells12131767 -
Cognition Oct 2023Trait impressions about others are a fundamental tool to navigate the rich social environment and yet a unitary model of its organizational principles is still lacking....
Trait impressions about others are a fundamental tool to navigate the rich social environment and yet a unitary model of its organizational principles is still lacking. The statistical properties of impression formation observed in previous studies are akin to processes that govern information encoding and storage in memory, suggesting similar cognitive and computational mechanisms. Here, in 2,780 participants, impression formation has been formalized with a computational model representing three organizational principles of memory (temporal, semantic and valence-related). The model specifically captured two main patterns of impression formation: (1) a negative valence effect that makes negative impressions loom longer than positive ones; (2) an interaction effect between the temporal and valence content that endorses more negative impressions when negative information is met first. This work shows that mechanisms of information encoding, storage and retrieval interact in ways that explain biased impression formation about social partners, thereby providing quantitative evidence for those mechanisms in individuals' impressions of others' social qualities. We discuss the implications of these results for social impressions in different, real-world contexts, and suggest how the proposed model might be extended to capture other kinds of effects, from negativity bias and pessimism to social discrimination.
Topics: Humans; Social Perception; Attitude; Bias
PubMed: 37506516
DOI: 10.1016/j.cognition.2023.105550 -
Journal of Pediatric Psychology Jun 2024High levels of optimism (and low levels of pessimism) are associated with improved physical health in adults. However, relatively less is known about these relations in...
OBJECTIVE
High levels of optimism (and low levels of pessimism) are associated with improved physical health in adults. However, relatively less is known about these relations in youth. The present study aimed to review the literature investigating optimism, pessimism, and physical health in children and adolescents from populations with and without health conditions.
METHODS
We conducted a scoping review up until February 2024. Studies were included if they sampled youth (average age ≤18 years) and treated optimism or pessimism as predictors of health behaviors or outcomes. Data on study and sample characteristics, health outcome, optimism construct, and findings were extracted from eligible papers and results were synthesized.
RESULTS
Sixty studies were retained. Most studies were conducted in North America, with adolescents, and used cross-sectional designs and self-reported measures of health. Measures of optimism and pessimism differed across studies. Roughly one-third of studies sampled medical populations. Health categories included substance use, diet and physical activity, sexual health practices, medical adherence, other health behaviors, cardiometabolic health, subjective health/health-related quality of life, pain, sleep, and oral health. Generally, we observed adaptive associations between optimism and health. Higher optimism and lower pessimism were most consistently associated with lower rates of substance use and lower cardiometabolic risk.
CONCLUSIONS
The presence of optimism or the absence of pessimism appears to be associated with various adaptive health outcomes among youth with and without health conditions. Developmental, methodological, and clinical considerations for future research are discussed, such as conducting longitudinal studies with objective measures of health and psychometrically validated instruments.
PubMed: 38879445
DOI: 10.1093/jpepsy/jsae045 -
Journal of Affective Disorders Sep 2023Obsessive-compulsive disorder (OCD) is a condition with poor treatment outcomes. Improved understanding of the aetiology can inform prevention and treatment approaches;... (Meta-Analysis)
Meta-Analysis Review
BACKGROUND
Obsessive-compulsive disorder (OCD) is a condition with poor treatment outcomes. Improved understanding of the aetiology can inform prevention and treatment approaches; hence several studies have assessed early maladaptive schemas (EMSs) in OCD. This systematic review and meta-analysis aimed to synthesise the evidence on relationships between the 18 EMSs and OCD.
METHODS
The study was conducted according to PRISMA guidelines and registered on PROSPERO (CRD42022329337). A systematic search of PubMed, PsycINFO, and CINAHL Complete was conducted on 4 June 2022. Studies in peer-reviewed journal articles were included if they assessed EMSs and OCD (diagnosis or symptom severity) in adults with a mean age of 18 years or older. Studies were excluded if they were not in English, did not include original quantitative data, or reported on case studies. Study details were tabulated and the meta-analysis findings were presented using forest plots. Methodological quality was assessed using the Appraisal tool for Cross-Sectional Studies (AXIS).
RESULTS
Based on 22 studies (pooled N = 3699), all 18 EMSs were positively correlated with OCD. The largest associations were with the dependence/incompetence (r = 0.40 95 % CI [0.32, 0.47]), vulnerability to harm or illness (r = 0.40 95 % CI [0.32, 0.48]), and negativity/pessimism schemas (r = 0.42 95 % CI [0.22, 0.58]).
LIMITATIONS
Several meta-analyses showed considerable heterogeneity and publication bias.
CONCLUSIONS
The findings suggest all EMSs, particularly those relating to disproportionate negative expectations and a perceived inability to cope, are implicated in OCD. Psychological prevention and treatment for OCD may benefit from targeting these schemas.
Topics: Adult; Humans; Adolescent; Cross-Sectional Studies; Obsessive-Compulsive Disorder; Treatment Outcome
PubMed: 37217101
DOI: 10.1016/j.jad.2023.05.053 -
Hormones and Behavior Mar 2024The cumulative negative effects of prolonged Hypothalamic-Pituitary-Adrenal axis (HPA axis) activation are associated with several age-related diseases. Some...
The cumulative negative effects of prolonged Hypothalamic-Pituitary-Adrenal axis (HPA axis) activation are associated with several age-related diseases. Some psychological traits such as optimism and pessimism have been shown to be related to both health and the stress response, although their relationship with the HPA axis is inconclusive. More stable HPA axis biomarkers, such as hair samples of cortisol (HC) and dehydroepiandrosterone (HDHEA), would help to clarify the association between these psychological traits and HPA axis functioning. The main aim of this study was to test the relationships between optimism and pessimism and chronic stress biomarkers measured in hair (HC and HDHEA). Additionally, a secondary objective was to explore sex differences in HC and HDHEA levels and their relationship with these psychological traits. We measured optimism, pessimism, and their combination (dispositional optimism) using the Life Orientation Test Revised (LOT-R) and chronic stress biomarkers (HC and HDHEA) in 119 healthy participants (46 men and 73 women) between 56 and 81 years old who belonged to a university program. Regression analyses controlling for perceived stress and BMI indicated that higher dispositional optimism was related to lower HC and HC:HDHEA (β = -0.256, p = .008 and β = -0.300, p = .002, respectively). More specifically, higher pessimism was related to higher HC (β = 0.235; p = .012) and HC:HDHEA (β = 0.240; p = .011), whereas higher optimism was associated with a lower HC:HDHEA(β = -0.205; p = .031). Moderation analyses showed no sex differences. To date, this is the first study to investigate the link between these traits and HC and HDHEA in older people. Our results confirm that positive and negative expectations about the future (i.e. optimism and pessimism) may play an important role in health due to their relationship with the HPA axis. They also strengthen the idea that the negative effects of pessimism have a greater weight than the protective effects of optimism in their relationship with HPA axis regulation.
Topics: Humans; Male; Female; Aged; Middle Aged; Aged, 80 and over; Hydrocortisone; Pessimism; Hypothalamo-Hypophyseal System; Pituitary-Adrenal System; Biomarkers; Hair; Dehydroepiandrosterone
PubMed: 38194858
DOI: 10.1016/j.yhbeh.2023.105474 -
Frontiers in Psychology 2023Positive and negative changes in outlook represent psychological changes that are the results of the cognitive processing of stressful and traumatic events by an...
BACKGROUND AND OBJECTIVES
Positive and negative changes in outlook represent psychological changes that are the results of the cognitive processing of stressful and traumatic events by an individual. The objectives of the study were (1) to determine the level of occurrence and types of positive and negative changes in connection with the COVID-19 pandemic among adults in Slovakia and (2) to study the role of personality factors such as hope (dispositional and perceived) and life orientation (optimism and pessimism) in the prediction of positive and negative changes in adults during the fourth pandemic wave.
METHODS
A Short Form of the Changes in Outlook Questionnaire (CiOQ-S), the Dispositional Hope Scale (DHS), the Perceived Hope Scale (PHS), and the Life Orientation Test (LOT-R) were administered. The research sample consisted of 102 participants, whose ages ranged from 20 to 65 years ( = 38.90, = 14.28). The research design was quantitative, exploratory, and confirmatory.
RESULTS
In total, 95% of participants reported positive changes related to COVID-19. Concurrently, up to 70% of these participants also reported negative changes from the impact of the pandemic. Only 25% of participants reported positive changes without noticing any negative perception of the consequences of the pandemic. Overall, 68% of participants reported negative changes related to COVID-19. Only 29% of participants reported negative changes without noticing any positive perception of the consequences of the pandemic. In total, up to 86% of participants agreed with experienced psychological changes (positive or negative) as a result of the COVID-19 pandemic. The high prevalence of positive changes along with the relatively high prevalence of negative changes related to the COVID-19 pandemic outline the question of whether reported positive changes represent real or illusory growth. Optimism and pessimism were found to be significant independent predictors of positive changes related to the COVID-19 pandemic. Hope was identified as a significant independent predictor of negative changes related to the COVID-19 pandemic.
PubMed: 37575434
DOI: 10.3389/fpsyg.2023.1151027 -
Revista Latino-americana de Enfermagem 2024the aim of this study is to investigate the relationship between death distress, psychological adjustment, optimism, pessimism and perceived stress among nurses working...
OBJECTIVE
the aim of this study is to investigate the relationship between death distress, psychological adjustment, optimism, pessimism and perceived stress among nurses working during the COVID-19 pandemic.
METHOD
this study was designed as cross-sectional/cohort. The population of the study involved 408 nurses from Northern Cyprus, which are registered as full members of the Nurse Council. The sample comprised 214 nurses, who volunteered to participate in the study. The study data was collected using a web-based online survey (Demographic form, the Coronavirus Stress Measure, The Optimism and Pessimism Questionnaire, The Brief Adjustment Scale-6, The Death Distress Scale).
RESULTS
the results indicated that perceived stress significantly and negatively predicted optimism (β = -0.21, p < 0.001) and pessimism (β = 0.38, p < 0.001). Perceived stress had significant and positive predictive effects on psychological adjustment (β = 0.31, p < 0.001) and death distress (β = 0.17, p < 0.01). Further analysis results revealed that pessimism mediates the association of stress with psychological adjustment and death distress; however, optimism only mediates the effect of stress on psychological adjustment among nurses.
CONCLUSION
a low level of pessimism is effective in strengthening nurses' psychological adjustment skills againt perceived stress and death distress. Nurses should consider behavioral strategies to help reduce the level of pessimism during periods such as pandemics.
BACKGROUND
(1) High levels of perceived stress increased higher score of psychological adjustment. (2) Pessimism mediates the association of stress with adjustment and death distress. (3) Optimism only mediates the effect of stress on psychological adjustment among nurses.
Topics: Humans; COVID-19; Cross-Sectional Studies; Optimism; Female; Adult; Male; Pessimism; Middle Aged; Pandemics; Emotional Adjustment; Nurses; Cyprus; Attitude to Death; Adaptation, Psychological; Cohort Studies; Stress, Psychological; Psychological Distress; SARS-CoV-2; Surveys and Questionnaires; Young Adult
PubMed: 38695430
DOI: 10.1590/1518-8345.7068.4173 -
Psychology and Aging Feb 2024Research across a number of different areas in psychology has long shown that optimism and pessimism are predictive of a number of important future life outcomes....
Research across a number of different areas in psychology has long shown that optimism and pessimism are predictive of a number of important future life outcomes. Despite a vast literature on the correlates and consequences, we know very little about how optimism and pessimism change across adulthood and old age and the sociodemographic factors that are associated with individual differences in such trajectories. In the present study, we conducted (parallel) analyses of standard items from the Life Orientation Test (Scheier & Carver, 1985) in three comprehensive data sets: Two-wave data from both the Berlin Aging Study II (N = 1,423, aged 60-88; M = 70.4, SD = 3.70) and the Midlife in the U.S. Study (N = 1,810 aged 60-84; M = 69.12, SD = 6.47) as well as cross-sectional data from the Survey of Health, Aging, and Retirement (N = 17,087, aged 60-99; M = 70.19, SD = 7.53). Using latent change-regression models and locally weighted smoothing curves revealed that optimism is on average very stable after age 60, with some evidence in Survey of Health, Aging, and Retirement of lowered optimism in very old age. Consistent across the three independent studies, pessimism evinced on average modest increases, ranging between .25 and .50 SD per 10 years of age. Of the sociodemographic factors examined, higher levels of education revealed the most consistent associations with lower pessimism, whereas gender evinced more study-specific findings. We take our results to demonstrate that age-related trajectories and correlates thereof differ for optimism and pessimism. Older adults appear to preserve into older ages those levels of optimistic expectations they have had at 60 years of age and show only modest increases in pessimism. We discuss possible reasons for these findings. (PsycInfo Database Record (c) 2024 APA, all rights reserved).
Topics: Humans; Aged; Adult; Cross-Sectional Studies; Pessimism; Aging; Educational Status; Individuality
PubMed: 38358694
DOI: 10.1037/pag0000789 -
PLoS Computational Biology Dec 2023Positive and negative affective states are respectively associated with optimistic and pessimistic expectations regarding future reward. One mechanism that might...
Positive and negative affective states are respectively associated with optimistic and pessimistic expectations regarding future reward. One mechanism that might underlie these affect-related expectation biases is attention to positive- versus negative-valence features (e.g., attending to the positive reviews of a restaurant versus its expensive price). Here we tested the effects of experimentally induced positive and negative affect on feature-based attention in 120 participants completing a compound-generalization task with eye-tracking. We found that participants' reward expectations for novel compound stimuli were modulated in an affect-congruent way: positive affect induction increased reward expectations for compounds, whereas negative affect induction decreased reward expectations. Computational modelling and eye-tracking analyses each revealed that these effects were driven by affect-congruent changes in participants' allocation of attention to high- versus low-value features of compounds. These results provide mechanistic insight into a process by which affect produces biases in generalized reward expectations.
Topics: Humans; Motivation; Emotions; Pessimism; Generalization, Psychological; Reward
PubMed: 38127874
DOI: 10.1371/journal.pcbi.1011707 -
Journal of Speech, Language, and... Sep 2023Repetitive negative thinking (RNT) is the process of engaging in negatively valenced and habitual thought patterns. RNT is strongly associated with mental health...
PURPOSE
Repetitive negative thinking (RNT) is the process of engaging in negatively valenced and habitual thought patterns. RNT is strongly associated with mental health conditions and often affects quality of life. This study explored RNT in older school-age children and adolescents who stutter to quantify the relationship between RNT and self-reported anxiety characteristics. An additional aim was to describe how individual differences in an adolescent's goal when speaking influences the frequency they engage in RNT.
METHOD
Ninety-nine children and adolescents who stutter aged 9-18 years completed a measurement of the frequency/severity of RNT, a screener of anxiety characteristics, and a measure of adverse impact related to stuttering. Children aged 10 years and above also answered questions about their goal when speaking.
RESULTS
Individual differences in RNT significantly predicted Overall Assessment of the Speaker's Experience of Stuttering (OASES) Total Scores more so than a child or adolescent's age. Higher generalized or social anxiety scores were significantly correlated with more frequent RNT and higher OASES Total Scores. Individual differences in goal when speaking (i.e., whether or not to stutter openly) were found to predict RNT. Finally, 22 children and adolescents (22.2%) also screened positive for generalized anxiety disorder and 32 (32.3%) screened positive for social anxiety disorder.
DISCUSSION
These data provide strong evidence that (a) many children and adolescents who stutter engage in RNT; (b) children and adolescents who engage more frequently in RNT or who have higher OASES Total Scores may be at increased risk for more characteristics of generalized or social anxiety; and (c) individual differences in goal when speaking can predict the degree to which an adolescent engages in RNT.
SUPPLEMENTAL MATERIAL
https://doi.org/10.23641/asha.23713296.
Topics: Child; Humans; Adolescent; Aged; Stuttering; Pessimism; Quality of Life; Anxiety; Anxiety Disorders; Surveys and Questionnaires
PubMed: 37494925
DOI: 10.1044/2023_JSLHR-23-00147