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Decorporation dilemma: Interplay of prussian blue and potassium iodide in radioactive contamination.Journal of Environmental Radioactivity Jul 2024The expansion of the nuclear industry has led to various radioactive effluents, originating from routine operations or catastrophic incidents such as those at Three Mile... (Review)
Review
The expansion of the nuclear industry has led to various radioactive effluents, originating from routine operations or catastrophic incidents such as those at Three Mile Island (USA), Chernobyl (Ukraine), and Fukushima (Japan). Research conducted after these events emphasizes Cesium-137 (137Cs) and iodine 131 (131I) as major contributors to harmful airborne dispersion and fallout. These isotopes infiltrate the human body via inhalation, ingestion, or wounds, posing significant health risks. Understanding contamination mechanisms and devising effective countermeasures are crucial in mitigating nuclear incident consequences. We propose that concurrent administration of Pru-Decorp™/Pru-Decorp-MG and potassium iodide (KI) could synergistically reduce the levels of 137Cs and block uptake of 131I, respectively, in nuclear incident scenarios. Pru-Decorp™ capsules contain insoluble ferric hexacyanoferrate(II) and are equivalent to USFDA-approved Radiogardase®-Cs, offering radiation exposure mitigation for Cs and Tl contamination. Pru-Decorp-MG capsules consist of insoluble PB and magnesium hydroxide, serving as a prophylactic measure to reduce the risk of internal Cs and Tl contamination for rescue responders. Pru-Decorp™/Pru-Decorp-MG binds Cs/Tl ions in the gastrointestinal tract, hindering absorption and promoting excretion, while KI saturates the thyroid gland with stable iodine, decreasing the uptake of radioactive iodine isotopes. Our hypothesis is supported by studies demonstrating the effectiveness of combination therapies, such as calcium alginate, iron(III) ferrocyanide, and KI, in decreasing the retention of radioisotopes in vital organs. To test this hypothesis, we propose a comprehensive research plan, including in vitro studies simulating gastrointestinal conditions, animal studies to evaluate the efficacy of both drugs simultaneously, and safety clinical trials comparing Pru-Decorp™/Pru-Decorp-MG alone, KI alone, and their combination. Expected outcomes include insights into the synergistic effects of Pru-Decorp™/Pru-Decorp-MG and KI, guiding the development of optimized treatment protocols for simultaneous administration during radioactive contamination incidents. This research aims to address significant critical gaps in nuclear incident preparedness by providing evidence-based recommendations for concurrent antidote use in scenarios involving multiple isotope contamination. Ultimately, this will enhance public health and safety during nuclear emergencies.
Topics: Potassium Iodide; Ferrocyanides; Cesium Radioisotopes; Iodine Radioisotopes; Humans; Radiation Monitoring; Fukushima Nuclear Accident; Radioactive Hazard Release
PubMed: 38781769
DOI: 10.1016/j.jenvrad.2024.107458 -
Heliyon Jul 2023Antimicrobial photodynamic therapy is emerging as a promising way to treat infections with minimal side effects. Typically, a single photosensitizer used in photodynamic...
Antimicrobial photodynamic therapy is emerging as a promising way to treat infections with minimal side effects. Typically, a single photosensitizer used in photodynamic therapy is capable of generating only one type of reactive oxygen species, which may have inadequate capability to eradicate certain types of microbes, especially species. Thus, the use of combined photosensitizers is examined as a means of achieving superior antimicrobial results. We postulate that bisdemethoxycurcumin, a type I reactive oxygen species generator, combined with potassium iodide, an antimicrobial iodide molecule, might exhibit superior antimicrobial effects compared to a single photosensitizer-mediated photodynamic therapy. The effects of bisdemethoxycurcumin + potassium iodide + dental blue light on reduction were examined. biofilms were treated with 20, 40 or 80 μM bisdemethoxycurcumin, 100 mM potassium iodide or a combination of these species for 20 min before irradiation with a dental blue light (90 J/cm). The negative and positive controls were phosphate buffer saline and nystatin at 1 : 100,000 units/ml, respectively. Candidal numbers were quantified at 0, 1, 6 and 24 h. Hydroxyl radicals were spectrophotometrically measured using 2-[6-(4'amino phynoxyl-3H-xanthen-3-on-9-yl)] benzoic acid or APF probe-mediated fluorescence intensity (Varioskan) at 490/515 nm (excitation/emission). Candidal counts and hydroxyl radical comparisons were performed using the Kruskal-Wallis test and one-way ANOVA, respectively. Correlations between candidal numbers and hydroxyl radical levels were done with a Pearson correlation test. Forty μM bisdemethoxycurcumin+100 mM KI could provide a 3.5 log CFU/ml reduction after 6 h. Bisdemethoxycurcumin alone generated OH levels that were strongly correlated with candidal reduction. In conclusion, 40 μM bisdemethoxycurcumin+100 mM KI could reduce biofilm.
PubMed: 37455953
DOI: 10.1016/j.heliyon.2023.e17490 -
Maedica Mar 2024This study aimed to evaluate the effect of silver diamine fluoride (SDF) in combination with or without glutathione (Glu) and potassium iodide (KI) on the fluoride...
Evaluating the Effect of Silver Diamine Fluoride, with or without Glutathione and Potassium Iodide, on Fluoride Release, Dentin Microhardness and Surface Properties of Dentin.
This study aimed to evaluate the effect of silver diamine fluoride (SDF) in combination with or without glutathione (Glu) and potassium iodide (KI) on the fluoride release and the enhancement of dentin microhardness. In this study, 90 intact premolar teeth from human subjects were allocated into nine groups, each consisting of ten samples: A) control; B) SDF; C) SDF combined with 5% Glu; D) SDF combined with 10% Glu; E) SDF combined with 20% Glu; F) KI after SDF; G) 5% Glu after SDF; H) 10% Glu after SDF; and I) 20% Glu after SDF. Data were analyzed using SPSS version 22 software and ANOVA and post-hoc and repeated measure test (P value <0.05). Dentin microhardness exhibited variations across different treatments, with the highest value being observed in the SDF-5% Glu group and the lowest in the control group. However, there was a significant difference between the mean values of SDF-5% Glu group and the SDF group. Significant increases in microhardness were observed when comparing SDF-5% Glu to SDF+5% Glu and SDF-10% Glu to SDF+10% Glu in peer groups (P value <0.05). Over time, there was a significant increase in the amount of fluoride released as compared to the initial day. The utilization of SDF-5% Glu group exhibited the most favorable effect on improving dentin hardness. Additionally, utilizing Glu in concentrations of 5% and 10% after SDF application proved more effective in increasing dentin microhardness than combining it with SDF. Moreover, in all three fluoride measurement periods, adding 5% Glu to SDF and using 20% Glu following SDF administration led to a significant increase in fluoride release compared to the application of SDF alone.
PubMed: 38736910
DOI: 10.26574/maedica.2024.19.11.48 -
Ultrasonics Sonochemistry Dec 2023Due to the complex physical and chemical interactions taking place in the sonicated medium, various methods have been proposed in the literature for a better...
Due to the complex physical and chemical interactions taking place in the sonicated medium, various methods have been proposed in the literature for a better understanding of the sonochemical system. In the present paper, the performance of calorimetry, iodometry, Fricke, 4-nitrophenol, HO, and ascorbic acid dosimetry techniques have been evaluated over the electric power range from 20 to 80 W (f = 300 kHz). These methods have been analyzed for distilled and seawater in light of the literature findings. It has been found that the lowest temperatures and calorimetric energies were obtained for seawater in comparison to distilled water. However, the discrepancy between both mediums disappears with the increase in the electric power up to 80 W. Compared to the calorimetry results, a similar trend was obtained for the KI dosimetry, where the discrepancy between both solutions (seawater and distilled water) increased with the reduction in the electric power down to 20 W. In contrast, over the whole range of the electric power (20-80 W), the HO dosimetry was drastically influenced by the salt composition of seawater, where, I formation was clearly reduced in comparison to the case of the distilled water. On the other hand, a fluctuated behavior was observed for the Fricke and 4-nitrophenol dosimetry methods, especially at the low electric powers (20 and 40 W). It has been found that dosimetry techniques based on ascorbic acid or potassium iodide are the best means for accurate quantification of the sonochemical activity in the irradiated liquid. As a result, it has been concluded, in terms of the dosimetry process's performance, that the dosimetry methods are in the following order: Ascorbic acid ≈ KI > Fricke > 4-nitrophenol > HO.
PubMed: 37944338
DOI: 10.1016/j.ultsonch.2023.106647