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Advanced Drug Delivery Reviews Oct 2023The use of cardiovascular implants is commonplace in clinical practice. However, reproducing the key bioactive and adaptive properties of native cardiovascular tissues... (Review)
Review
The use of cardiovascular implants is commonplace in clinical practice. However, reproducing the key bioactive and adaptive properties of native cardiovascular tissues with an artificial replacement is highly challenging. Exciting new treatment strategies are under development to regenerate (parts of) cardiovascular tissues directly in situ using immunomodulatory biomaterials. Direct exposure to the bloodstream and hemodynamic loads is a particular challenge, given the risk of thrombosis and adverse remodeling that it brings. However, the blood is also a source of (immune) cells and proteins that dominantly contribute to functional tissue regeneration. This review explores the potential of the blood as a source for the complete or partial in situ regeneration of cardiovascular tissues, with a particular focus on the endothelium, being the natural blood-tissue barrier. We pinpoint the current scientific challenges to enable rational engineering and testing of blood-contacting implants to leverage the regenerative potential of the blood.
Topics: Humans; Biocompatible Materials; Cardiovascular System; Prostheses and Implants; Tissue Engineering
PubMed: 37690484
DOI: 10.1016/j.addr.2023.115085 -
Science (New York, N.Y.) Aug 2023Bioelectronic implants could use semiconductors that adhere to wet, dynamic tissues.
Bioelectronic implants could use semiconductors that adhere to wet, dynamic tissues.
Topics: Prostheses and Implants; Semiconductors; Tissue Adhesives; Humans; Animals; Swine
PubMed: 37561863
DOI: 10.1126/science.adj3284 -
Facial Plastic Surgery Clinics of North... Aug 2023Cheek augmentation is frequently used in facial feminization surgery. Options for augmentation include both surgical and nonsurgical techniques, such as autologous and... (Review)
Review
Cheek augmentation is frequently used in facial feminization surgery. Options for augmentation include both surgical and nonsurgical techniques, such as autologous and non-autologous injections, implants, and osteotomies. Cheek augmentation can be combined with other facial procedures. Complications of cheek augmentation include malposition, resorption, asymmetry, and unfavorable cosmetic results. Cheek augmentation should be considered as part of an overall facial feminizing plan.
Topics: Humans; Cheek; Face; Facial Bones; Sex Reassignment Surgery; Prostheses and Implants
PubMed: 37348982
DOI: 10.1016/j.fsc.2023.04.002 -
European Journal of Cardio-thoracic... Jan 2024
Topics: Humans; Fontan Procedure; Heart Ventricles; Prostheses and Implants
PubMed: 38218719
DOI: 10.1093/ejcts/ezae012 -
Critical Reviews in Biomedical... 2024The efficacy of every neuromodulation modality depends upon the characteristics of the electrodes used to stimulate the chosen target. The geometrical, chemical,... (Review)
Review
The efficacy of every neuromodulation modality depends upon the characteristics of the electrodes used to stimulate the chosen target. The geometrical, chemical, mechanical and physical configuration of electrodes used in neurostimulation affects several performance attributes like stimulation efficiency, selectivity, tissue response, etc. The efficiency of stimulation in relation to electrode impedance is influenced by the electrode material and/or its geometry. The nature of the electrode material determines the charge transfer across the electrode-tissue interface, which also relates to neuronal tissue damage. Electrode morphology or configuration pattern can facilitate the modulation of extracellular electric field (field shaping). This enables selective activation of neurons and minimizes side effects. Biocompatibility and biostability of the electrode materials or electrode coating have a role in glial formation and tissue damage. Mechanical and electrochemical stability (corrosion resistance) determines the long-term efficacy of any neuromodulation technique. Here, a review of electrodes typically used for implantable neuromodulation is discussed. Factors affecting the performance of electrodes like stimulation efficiency, selectivity and tissue responses to the electrode-tissue interface are discussed. Technological advancements to improve electrode characteristics are also included.
Topics: Humans; Electric Impedance; Electrodes; Prostheses and Implants
PubMed: 37938182
DOI: 10.1615/CritRevBiomedEng.2023049282 -
The Journal of Prosthetic Dentistry Jul 2023Screwmentable prostheses were developed to combine the benefits of screw retention and cement retention. However, data are limited on the clinical performance of this... (Review)
Review
STATEMENT OF PROBLEM
Screwmentable prostheses were developed to combine the benefits of screw retention and cement retention. However, data are limited on the clinical performance of this type of prosthesis.
PURPOSE
The purpose of this systematic review was to collect scientific evidence on screwmentable prostheses and evaluate their long-term clinical behavior.
MATERIAL AND METHODS
An electronic search was conducted by 2 independent reviewers for articles published in scientific dental journals in English from 2004 to April 2020. The search strategy followed the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. Inclusion criteria were scientific studies concerning the screwmentable type of prosthesis.
RESULTS
The search provided 494 records. Of these, 24 studies fulfilled the inclusion criteria and were included in the review. The included articles presented significant heterogeneity concerning the manufacturing process and the materials used. One randomized clinical trial, 2 prospective clinical studies, 14 in vitro studies, 3 protocol descriptions, 1 case series, and 3 case reports were included.
CONCLUSIONS
Based on the systematic search of the literature, it is concluded that the screwmentable prosthesis combines advantages of both cement-retained and screw-retained restorations, including passive fit, retrievability, excess cement control, tissue-friendly emergence profile, and improved esthetics. Nevertheless, data from well-designed clinical trials are limited, and further research is required to provide evidence on their long-term clinical behavior.
Topics: Dental Implants; Dental Prosthesis Retention; Prospective Studies; Dental Prosthesis, Implant-Supported; Esthetics, Dental; Dental Cements; Glass Ionomer Cements; Randomized Controlled Trials as Topic
PubMed: 34740460
DOI: 10.1016/j.prosdent.2021.08.027 -
Child's Nervous System : ChNS :... Oct 2023Pediatric hydrocephalus is a common and challenging condition. To date, the ventriculoperitoneal shunt (VPS) is still the main lifesaving treatment option. Nonetheless,... (Review)
Review
PURPOSE
Pediatric hydrocephalus is a common and challenging condition. To date, the ventriculoperitoneal shunt (VPS) is still the main lifesaving treatment option. Nonetheless, it remains imperfect and is associated with multiple short- and long-term complications. This paper is a reflective review of the current state of the VPS, our knowledge gaps, and the future state of shunts in neurosurgical practice.
METHODS AND RESULTS
The authors' reflections are based on a review of shunts and shunt-related literature.
CONCLUSION
Overall, there is still an urgent need for the neurosurgical community to actively improve current strategies for shunt failures and shunt-related morbidity. The authors emphasize the role of collaborative efforts amongst like-minded clinicians to establish pragmatic approaches to avoid shunt complications.
Topics: Child; Humans; Cerebrospinal Fluid Shunts; Ventriculoperitoneal Shunt; Hydrocephalus; Prostheses and Implants
PubMed: 37462810
DOI: 10.1007/s00381-023-06070-4 -
Biomacromolecules Oct 2023A significant part of medicine relies on biomaterials, which are designed to interact with biological tissues for therapeutic or diagnostic purposes. A number of major...
A significant part of medicine relies on biomaterials, which are designed to interact with biological tissues for therapeutic or diagnostic purposes. A number of major trends can be distinguished in the multidisciplinary field of biomaterials science, including the precise synthesis of biomaterial building blocks, elucidation of biomaterial processing-structure-property correlations, as well as clarification of the interactions between living tissues and biomaterials. Moreover, advances in biofabrication facilitate the development of tailored implants with improved functionality, whereas recent achievements in medical imaging allow for a detailed evaluation of the performance and spatiotemporal behavior of medical devices and nanomedicine formulations.
Topics: Polymers; Biocompatible Materials; Prostheses and Implants; Nanomedicine
PubMed: 37811641
DOI: 10.1021/acs.biomac.3c00332 -
ACS Biomaterials Science & Engineering Jul 2023The efficacy of implanted biomaterials is largely dependent on the response of the host's immune and stromal cells. Severe foreign body response (FBR) can impede the... (Review)
Review
The efficacy of implanted biomaterials is largely dependent on the response of the host's immune and stromal cells. Severe foreign body response (FBR) can impede the integration of the implant into the host tissue and compromise the intended mechanical and biochemical function. Many features of FBR, including late-stage fibrotic encapsulation of implants, parallel the formation of fibrotic scar tissue after tissue injury. Regenerative organisms like zebrafish and salamanders can avoid fibrosis after injury entirely, but FBR in these research organisms is rarely investigated because their immune competence is much lower than humans. The recent characterization of a regenerative mammal, the spiny mouse (), has inspired us to take a closer look at cellular regulation in regenerative organisms across the animal kingdom for insights into avoiding FBR in humans. Here, we highlight how major features of regeneration, such as blastema formation, macrophage polarization, and matrix composition, can be modulated across a range of regenerative research organisms to elucidate common features that may be harnessed to minimize FBR. Leveraging a deeper understanding of regenerative biology for biomaterial design may help to reduce FBR and improve device integration and performance.
Topics: Humans; Animals; Biocompatible Materials; Foreign-Body Reaction; Zebrafish; Prostheses and Implants; Foreign Bodies; Fibrosis; Mammals
PubMed: 36222692
DOI: 10.1021/acsbiomaterials.2c00486 -
Acta Neurochirurgica Aug 2023
Topics: Humans; Skull; Prostheses and Implants
PubMed: 37335331
DOI: 10.1007/s00701-023-05662-y