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Journal of Translational Medicine Jul 2023Abdominal obesity has long been considered as a crucial risk factor of stroke. Chinese visceral adiposity index (CVAI), a novel surrogate indicator of abdominal obesity,...
Association between Chinese visceral adiposity index and risk of stroke incidence in middle-aged and elderly Chinese population: evidence from a large national cohort study.
BACKGROUND
Abdominal obesity has long been considered as a crucial risk factor of stroke. Chinese visceral adiposity index (CVAI), a novel surrogate indicator of abdominal obesity, has been confirmed as a better predictor for coronary heart disease than other indicators in Asian population. However, the data on the relationship of CVAI with stroke is limited. The objective of our study is evaluating the relationship between CVAI and stroke incidence.
METHODS
In the present study, we enrolled 7242 middle-aged and elderly residents from the China Health and Retirement Longitudinal Study (CHARLS) and placed them into groups according to quartile of CVAI. The outcome of interest was stroke. Kaplan-Meier curves were used to estimate the cumulative incidences of stroke. Cox regression analyses and multivariable-adjusted restricted cubic spline (RCS) curves were performed to evaluate the relationship between CVAI and incident stroke. Multiple sensitivity analyses and subgroups analyses were performed to test the robustness of the findings.
RESULTS
During a median 84 months of follow-up, 612 (8.45%) participants experienced incident stroke, and the incidences of stroke for participants in quartiles (Q) 1-4 of CVAI were 4.42%, 7.29%, 9.06% and 13.04%, respectively. In the fully adjusted model, per 1.0-SD increment in CVAI has a significant increased risk of incident stroke: hazard ratio (HR) [95% confidence interval (CI)] was 1.17 (1.07-1.28); compared with participants in Q1 of CVAI, the HRs (95% CI) of incident stroke among those in Q2-4 were 1.47 (1.10-1.95), 1.62 (1.22-2.15), and 1.70 (1.28-2.27), respectively. Subgroups analyses suggested the positive association was significant in male participants, without diabetes, hypertension and heart disease. The findings were robust in all the sensitivity analyses. Additional, RCS curves showed a significant dose-response relationship of CVAI with risk of incident stroke (P for non-linear trend = 0.319).
CONCLUSION
Increased CVAI is significantly associated with higher risk of stroke incidence, especially in male individuals, without hypertension, diabetes and heart disease. The findings suggest that baseline CVAI is a reliable and effective biomarker for risk stratification of stroke, which has far-reaching significance for primary prevention of stroke and public health.
Topics: Middle Aged; Aged; Humans; Male; Cohort Studies; Incidence; Obesity, Abdominal; Longitudinal Studies; Adiposity; East Asian People; Risk Factors; Stroke; Obesity; Diabetes Mellitus; China; Heart Diseases; Hypertension
PubMed: 37525182
DOI: 10.1186/s12967-023-04309-x -
Methodist DeBakey Cardiovascular Journal 2023Philip Alexander, MD, is a native Texan, retired physician, and accomplished musician and artist. After 41 years as an internal medicine physician, Dr. Phil retired from...
Philip Alexander, MD, is a native Texan, retired physician, and accomplished musician and artist. After 41 years as an internal medicine physician, Dr. Phil retired from his practice in College Station in 2016. A lifelong musician and former music professor, he often performs as an oboe soloist for the Brazos Valley Symphony Orchestra. He began exploring visual art in 1980, evolving from pencil sketches-including an official White House portrait of President Ronald Reagan-to the computer-generated drawings featured in this journal. His images, which first appeared in this journal in the spring of 2012, are his own original creations. If you would like to see your art published in the , submit your creation online at journal.houstonmethodist.org as a "Humanities" entry.
PubMed: 38028965
DOI: 10.14797/mdcvj.1293 -
Methodist DeBakey Cardiovascular Journal 2023Philip Alexander, MD, is a native Texan, retired physician, and accomplished musician and artist. After 41 years as an internal medicine physician, Dr. Phil retired from...
Philip Alexander, MD, is a native Texan, retired physician, and accomplished musician and artist. After 41 years as an internal medicine physician, Dr. Phil retired from his practice in College Station in 2016. A lifelong musician and former music professor, he often performs as an oboe soloist for the Brazos Valley Symphony Orchestra. He began exploring visual art in 1980, evolving from pencil sketches-including an official White House portrait of President Ronald Reagan-to the computer-generated drawings featured in this journal. His images, which first appeared in this journal in the spring of 2012, are his own original creations. If you would like to see your art published in the , submit your creation online at journal.houstonmethodist.org as a "Humanities" entry.
PubMed: 37547897
DOI: 10.14797/mdcvj.1267 -
Acta Psychologica Nov 2023
PubMed: 37977913
DOI: 10.1016/j.actpsy.2023.104076 -
The Canadian Veterinary Journal = La... Aug 2023This column is a communications tool for food animal production and related issues. It is expected to fill an important gap, as much of the narrative regarding food...
This column is a communications tool for food animal production and related issues. It is expected to fill an important gap, as much of the narrative regarding food animal agriculture and food animal veterinary practice is not written by food animal veterinarians. This column will be a regular feature of , coordinated by Dr. Robert Tremblay and intended to inform food animal veterinarians and others who want to understand more about the day-to-day professional activities of food animal veterinarians. Recently retired, Dr. Tremblay spent 40 y in professional life working in large animal veterinary medicine. For most of that time, his primary interest was food animal medicine. Dr. Tremblay takes great satisfaction in having been involved in food animal veterinary medicine. He is grateful to have worked with dedicated food animal veterinarians, farmers, and ranchers in Canada and beyond. .
Topics: Male; Animals; Humans; Agriculture; Farmers; Veterinarians; Canada; Communication; Veterinary Medicine
PubMed: 37529394
DOI: No ID Found -
GeroScience Dec 2023Chronic, low-level systemic inflammation associated with aging, or inflammaging, is a risk factor for several chronic diseases and mortality. Using data from the Health...
Chronic, low-level systemic inflammation associated with aging, or inflammaging, is a risk factor for several chronic diseases and mortality. Using data from the Health and Retirement Study, we generated a continuous latent variable for systemic inflammation from seven measured indicators of inflammation and examined associations with another biomarker of biological aging, DNA methylation age acceleration measured by epigenetic clocks, and 4-year mortality (N = 3,113). We found that greater systemic inflammation was positively associated with DNA methylation age acceleration for 10 of the 13 epigenetic clocks, after adjustment for sociodemographics and chronic disease risk factors. The latent variable for systemic inflammation was associated with 4-year mortality independent of DNA methylation age acceleration and was a better predictor of 4-year mortality than any of the epigenetic clocks examined, as well as mortality risk factors, including obesity and multimorbidity. Inflammaging and DNA methylation age acceleration may represent different biological processes contributing to mortality risk. Leveraging multiple measured inflammation markers to capture inflammaging is important for biology of aging research.
Topics: Humans; Epigenesis, Genetic; Retirement; Aging; DNA Methylation; Inflammation; Biomarkers
PubMed: 37501048
DOI: 10.1007/s11357-023-00880-9 -
Eplasty 2023
PubMed: 37519927
DOI: No ID Found