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Nutrients Oct 2019The purpose of this randomized, placebo-controlled, blind study was to investigate the effects of the drinkable nutraceutical ELASTEN (QUIRIS Healthcare, Gütersloh,... (Randomized Controlled Trial)
Randomized Controlled Trial
The purpose of this randomized, placebo-controlled, blind study was to investigate the effects of the drinkable nutraceutical ELASTEN (QUIRIS Healthcare, Gütersloh, Germany) on skin aging and skin health. Drinking ampoules provides a blend of 2.5 g of collagen peptides, acerola fruit extract, vitamin C, zinc, biotin, and a native vitamin E complex. This controlled interventional trial was performed on 72 healthy women aged 35 years or older. They received either the food supplement ( = 36) or a placebo ( = 36) for twelve weeks. A skin assessment was carried out and based on objective validated methods, including corneometry (skin hydration), cutometry (elasticity), the use of silicon skin replicas with optical 3D phase-shift rapid in-vivo measurements (PRIMOS) (roughness), and skin sonography (density). The verum group was followed for an additional four weeks (without intake of the test product) to evaluate the sustainability of the changes induced by the intake of the test product. The test product significantly improved skin hydration, elasticity, roughness, and density. The differences between the verum group and the placebo group were statistically significant for all test parameters. These positive effects were substantially retained during the follow-up. The measured effects were fully consistent with the subjective assessments of the study participants. The nutraceutical was well tolerated.
Topics: Administration, Oral; Adult; Aged; Collagen; Dietary Supplements; Female; Humans; Middle Aged; Skin; Skin Aging; Surveys and Questionnaires
PubMed: 31627309
DOI: 10.3390/nu11102494 -
Dermatologic Therapy Sep 2022Combination therapy with biotin and dexpanthenol is a well-known practice in preventing and treating hair loss, however, it is not well studied. In this study, we... (Randomized Controlled Trial)
Randomized Controlled Trial
Combination therapy with biotin and dexpanthenol is a well-known practice in preventing and treating hair loss, however, it is not well studied. In this study, we compared the efficacy of the 6-week treatment with two brands of biotin and dexpanthenol for the treatment of diffuse hair loss. Fifty eligible patients with diffused pattern hair loss, (41 women and 9 men) were randomized in a 1:1 ratio to receive either 6 weekly injections of dexpanthenol ampoule 250 mg/2 ml and biotin ampoule 5 mg/1 ml, manufactured by Pars Behvarzan or Bayer Company. Combing test, Standard scalp photography and trichoscan assessment were performed before the first treatment session and one and 8 weeks after the last one. Patients' satisfaction and drug adverse reactions were also recorded. One and eight weeks after the last treatment session, hair fall count and total hair density significantly improved in both groups (p-value <0.01 for hair fall count and 0.04 and 0.02, for hair density in Pars and Bayer groups, respectively). There was no significant difference between the two groups in any other trichoscan parameter, except for improvement in terminal/vellus hair ratio in the Bayer group in both follow up visits, compared to the Pars group (p-value = 0.02 and 0.033 for weeks one and eight). Six-week treatment with both brands of biotin and dexpanthenol was effective and safe in people with diffused pattern hair loss.
Topics: Alopecia; Biotin; Double-Blind Method; Female; Hair; Humans; Injections, Intramuscular; Male; Pantothenic Acid; Treatment Outcome
PubMed: 35791704
DOI: 10.1111/dth.15695 -
IUCrData Aug 2023The title compound, digadolinium(III) oxidodisilicate, Gd[SiO], was obtained in its -type crystal structure after attempts to synthesize GdBr[AsO] as a by-product from...
The title compound, digadolinium(III) oxidodisilicate, Gd[SiO], was obtained in its -type crystal structure after attempts to synthesize GdBr[AsO] as a by-product from fused silica ampoules. It crystallizes isotypically with -type Eu[SiO]. This structure consists of layers of ecliptically arranged oxidodisilicate [SiO] units separated from each other by bilayers consisting of Gd cations.
PubMed: 37693777
DOI: 10.1107/S2414314623006545 -
International Urogynecology Journal Mar 2020The aim of this study was to evaluate the effectiveness of perineal massage, pelvic floor muscle training (PFMT) and a pelvic floor dysfunction (PFD) prevention... (Randomized Controlled Trial)
Randomized Controlled Trial
INTRODUCTION AND HYPOTHESIS
The aim of this study was to evaluate the effectiveness of perineal massage, pelvic floor muscle training (PFMT) and a pelvic floor dysfunction (PFD) prevention educational program in pregnant women above the age of 35 years to prevent perineal tear and episiotomy.
METHODS
A randomized parallel assignment study involved two groups of pregnant women at the obstetrics outpatient clinic 4 weeks prior to their due date. The first group (n = 200) was educated to do digital perineal massage and pelvic floor muscle training and received an educational PFD prevention program. The second group (n = 200) received only the prevention education program. Occurrence of perineal laceration was reported at time of delivery as a primary outcome. Statistical analysis was done using the IBM SPSS computer program (Statistical Package for the Social Sciences; IBM Corp, Armonk, NY, USA), release 22 for Microsoft Windows.
RESULTS
Delivery was significantly less complicated by perineal tear, episiotomy and postnatal pain in the first than in the second group (p < 0.05). Grades of perineal tear were mostly of first and second degree in the first group compared with the second group. We found a significantly lower need for analgesia and fewer ampoules required during the hospital stay in the first group (p < 0.001, 0.002, respectively).
CONCLUSIONS
Performing antenatal digital perineal massage and PFMT in addition to health education is recommended to reduce perineal complications.
Topics: Adult; Episiotomy; Female; Humans; Massage; Pelvic Floor; Perineum; Pregnancy; Pregnant Women
PubMed: 30941442
DOI: 10.1007/s00192-019-03937-6 -
Recherche En Soins Infirmiers 2020Despite its proven dangers, the ward stock drug distribution system predominates in French hospitals. This system allows 12 million injectable ampoules of concentrated...
Despite its proven dangers, the ward stock drug distribution system predominates in French hospitals. This system allows 12 million injectable ampoules of concentrated potassium chloride to circulate uncontrolled each year. Such a situation is absurd for the following reasons : 1) injected by mistake, concentrated potassium kills within seconds ; 2) the true incidence of potassium-related fatalities and incidents is unknown ; 3) fatal intravenous injection of potassium produces no specific anatomical changes and subtle, if any, findings at autopsy ; 4) it is used for capital punishment by lethal injection in various countries ; and 5) healthcare worker serial killers benefit from the fact that potassium is not identifiable in post-mortem examinations and that investigations to find the murderer are complex and of uncertain outcome. Other medications classed as high-risk have similar characteristics to those of concentrated potassium solutions. Injectable potassium can therefore be regarded as emblematic of the lack of safety of the drug use process in French hospitals. The priority measure to protect patients from this deadly risk is to remove these drugs from uncontrolled ward stocks and to provide premixed potassium solutions. Evidence of the increased safety of the unit dose drug dispensing system should compel health policy makers to systematically implement it, thus bringing the drug use process into compliance with existing French and European regulations.
PubMed: 35724035
DOI: 10.3917/rsi.141.0078 -
IUCrData Jul 2023The title compound, dicerium(III) oxidodisilicate, Ce[SiO], was obtained as a by-product in its -type structure after attempts to synthesize CeSbOCl from fused silica...
The title compound, dicerium(III) oxidodisilicate, Ce[SiO], was obtained as a by-product in its -type structure after attempts to synthesize CeSbOCl from fused silica ampoules. It crystallizes isotypically with -La[SiO]. The four crystallographically distinct Ce cations form distorted square anti-prisms, capped square anti-prisms, and bicapped square anti-prisms as coordination polyhedra consisting of oxygen atoms. Four crystallographically different silicon atoms recruit the centers of two different isolated [SiO] units.
PubMed: 37937134
DOI: 10.1107/S2414314623005916 -
Journal of Cosmetic Science 2021Plants are a rich source of a wide variety of bioactive compounds that can be used for the preparation of cosmetics. Natural cosmetics with plant components such as... (Review)
Review
Plants are a rich source of a wide variety of bioactive compounds that can be used for the preparation of cosmetics. Natural cosmetics with plant components such as vitamins, polyphenols, and alkaloids have become more and more popular. Alkaloids are important secondary metabolites in plants. They are known to possess therapeutic properties. Alkaloids can be used in the production of tonics, creams, lotions, face and hair masks, compresses for skin problems with numerous inflammations, and discoloration and antiaging products, as well as for reducing the formation of cellulitis. Alkaloids are also used in the production of ampoules for cosmetologists and aesthetic medicine doctors. However, at higher doses, they may exhibit toxic properties. Several studies have been carried out in evaluation of the activity of alkaloids from various plants for their use in cosmetics. This review describes alkaloids (caffeine, capsaicin, berberine, piperine, spilanthol, and anatabine) derived from various plants that are used in cosmetics, as well as their reported activities.
Topics: Alkaloids; Cosmetics; Plants
PubMed: 35361327
DOI: No ID Found -
Applied Radiation and Isotopes :... Oct 2023Lu decays through low-energy β- and γ-emissions in addition to conversion and Auger electrons. To support the use of this radiopharmaceutical in Switzerland, a Lu...
Lu decays through low-energy β- and γ-emissions in addition to conversion and Auger electrons. To support the use of this radiopharmaceutical in Switzerland, a Lu solution was standardised using the β-γ coincidence technique, as well as the TDCR method. The solution had no Lu impurity. Primary coincidence measurements, with plastic scintillators for beta detection, were carried out using both analogue and digital electronics. TDCR measurements using only defocusing were also made. Monte Carlo calculations were used to compute the detection efficiency. The coincidence measurements with both analogue and digital electronics are compatible within one standard uncertainty, but they are lower than (and discrepant with) the TDCR measurements. An ampoule of this solution was submitted to the BIPM as a contribution to the Système International de Référence.
PubMed: 37597267
DOI: 10.1016/j.apradiso.2023.110986 -
Applied Radiation and Isotopes :... Dec 2020Tb, which emits low-energy β- and γ-particles in addition to conversion and Auger electrons, has aroused increased interest for medical imaging and therapy. To support...
Tb, which emits low-energy β- and γ-particles in addition to conversion and Auger electrons, has aroused increased interest for medical imaging and therapy. To support the use of this radionuclide, aTb solution was standardised using the β-γ coincidence technique, as well as the TDCR method. The solution had 4.5·10% of Tb impurities. Primary coincidence measurements, with plastic or liquid scintillators for beta detection, were carried out using both analogue and digital electronics. TDCR measurements using defocusing, grey filtering and quenching for varying the efficiency were also made. Monte Carlo calculations were used to compute the detection efficiency. The coincidence measurements with analogue electronics and the TDCR show a good consistency, and are compatible with the digital coincidence results within uncertainties. An ampoule of this solution was submitted to the BIPM as a contribution to the international reference system.
PubMed: 32961523
DOI: 10.1016/j.apradiso.2020.109411