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Therapie 2021
Topics: Adverse Drug Reaction Reporting Systems; Bismuth; Drug-Related Side Effects and Adverse Reactions; Humans; Pharmacovigilance
PubMed: 33218671
DOI: 10.1016/j.therap.2020.11.001 -
Neurotoxicology Mar 2021
Topics: Aluminum Compounds; Aluminum Hydroxide; Aluminum Oxide; Alzheimer Disease; Animals; Humans; Risk Assessment; Toxicity Tests; Water Pollutants, Chemical
PubMed: 33278452
DOI: 10.1016/j.neuro.2020.12.001 -
The Veterinary Clinics of North... Jan 2021A range of gastroprotective drugs are available for the treatment of esophagitis and gastroduodenal mucosal injury including acid suppressants (ie, histamine-2 receptor... (Review)
Review
A range of gastroprotective drugs are available for the treatment of esophagitis and gastroduodenal mucosal injury including acid suppressants (ie, histamine-2 receptor antagonists, proton pump inhibitors), coating agents, prostaglandin analogs, and antacids. Of these, the proton pump inhibitors are the most effective drugs for the medical treatment of upper gastrointestinal injury. However, proton pump inhibitors are not effective for all causes of upper gastrointestinal injury. The choice of gastroprotective drug should be guided by the cause and location of gastrointestinal injury and the potential for adverse effects.
Topics: Animals; Antacids; Dog Diseases; Dogs; Histamine H2 Antagonists; Proton Pump Inhibitors; Stomach Ulcer
PubMed: 33131917
DOI: 10.1016/j.cvsm.2020.09.001 -
Indian Journal of Gastroenterology :... Oct 2019The Indian Society of Gastroenterology developed this evidence-based practice guideline for management of gastroesophageal reflux disease (GERD) in adults. A modified...
The Indian Society of Gastroenterology developed this evidence-based practice guideline for management of gastroesophageal reflux disease (GERD) in adults. A modified Delphi process was used to develop this consensus containing 58 statements, which were generated by electronic voting iteration as well as face-to-face meeting and review of the supporting literature primarily from India. These statements include 10 on epidemiology, 8 on clinical presentation, 10 on investigations, 23 on treatment (including medical, endoscopic, and surgical modalities), and 7 on complications of GERD. When the proportion of those who voted either to accept completely or with minor reservation was 80% or higher, the statement was regarded as accepted. The prevalence of GERD in India ranges from 7.6% to 30%, being < 10% in most population studies, and higher in cohort studies. The dietary factors associated with GERD include use of spices and non-vegetarian food. Helicobacter pylori is thought to have a negative relation with GERD; H. pylori negative patients have higher grade of symptoms of GERD and esophagitis. Less than 10% of GERD patients in India have erosive esophagitis. In patients with occasional or mild symptoms, antacids and histamine H receptor blockers (H2RAs) may be used, and proton pump inhibitors (PPI) should be used in patients with frequent or severe symptoms. Prokinetics have limited proven role in management of GERD.
Topics: Adult; Antacids; Consensus; Diet; Esophagitis; Female; Gastroenterology; Gastroesophageal Reflux; Helicobacter Infections; Helicobacter pylori; Histamine H2 Antagonists; Humans; India; Male; Practice Guidelines as Topic; Prevalence; Proton Pump Inhibitors; Societies, Medical
PubMed: 31802441
DOI: 10.1007/s12664-019-00979-y -
Nutrients Jan 2020Chronic functional constipation is a frequent condition. The aim of the study was to evaluate the efficacy of the probiotic Lactobacillus (L.) reuteri DSM 17938 and... (Randomized Controlled Trial)
Randomized Controlled Trial
OBJECTIVE
Chronic functional constipation is a frequent condition. The aim of the study was to evaluate the efficacy of the probiotic Lactobacillus (L.) reuteri DSM 17938 and magnesium oxide (MgO) for relieving chronic functional constipation in children.
STUDY DESIGN
A prospective, double-blind, placebo-controlled, randomized, and parallel-group trial was conducted in five pediatric outpatient clinics in Japan. Sixty patients who were more than six months old and under six years of age with a diagnosis of functional constipation according to Rome IV criteria were randomly divided into three groups: group A (n = 20) received L. reuteri DSM 17938 and lactose hydrate as a placebo of MgO; group B (n = 19) received L. reuteri DSM 17938 and MgO; and group C (n = 21) received a placebo of L. reuteri DSM 17938 and MgO.
RESULTS
All three groups exhibited significant improvement in defecation frequency in the fourth week compared with the baseline condition (group A: p < 0.05; group B: p < 0.05; group C: p < 0.05). The MgO group and combination group showed a significant decrease in stool consistency, but the L. reuteri DSM 17938 group did not (group A: p = 0.079; group B: p < 0.05; group C: p < 0.05). MgO significantly suppressed the presence of the genus Dialister. Defecation frequency negatively correlated with the frequency of Clostridiales-belonging bacteria among the gut microbiome.
CONCLUSIONS
L. rueteri DSM 17938 and MgO were both effective in the management of functional constipation in young children. MgO caused an imbalance in the gastrointestinal microbiome, which was not the case in the probiotic group.
Topics: Antacids; Child, Preschool; Chronic Disease; Constipation; Double-Blind Method; Female; Humans; Infant; Limosilactobacillus reuteri; Magnesium Oxide; Male; Probiotics
PubMed: 31952280
DOI: 10.3390/nu12010225 -
Ugeskrift For Laeger Jun 2022Keloids are pathological scars extending beyond the initial wound's natural borders. The condition occurs as a result of impaired wound healing with excessive collagen... (Review)
Review
Keloids are pathological scars extending beyond the initial wound's natural borders. The condition occurs as a result of impaired wound healing with excessive collagen deposition. Keloid scars frequently recur, rarely regress, and have a tendency to grow over time. They are aesthetically disfiguring and can be devastating for patients, both physically and emotionally. This review finds that prevention and early intervention are essential for good results. Treatment is often challenging. There are no standardized management guidelines currently available but a combinational therapeutic approach appears to be beneficial.
Topics: Antacids; Collagen; Humans; Keloid; Penicillins; Recurrence
PubMed: 35781362
DOI: No ID Found -
Clinical Gastroenterology and... Dec 2019
Topics: Bismuth; Helicobacter Infections; Helicobacter pylori; Humans
PubMed: 31757363
DOI: 10.1016/j.cgh.2019.05.054 -
Lancet (London, England) Mar 2021
Topics: Aluminum Hydroxide; Clinical Trials as Topic; Drug Compounding; Humans; Journalism, Medical; Papillomavirus Vaccines; Phosphates; Placebos; Safety; Societies, Scientific; Vaccines, Combined
PubMed: 33743866
DOI: 10.1016/S0140-6736(21)00382-2 -
Clinical Rheumatology Aug 2020
Topics: Calcium Carbonate; Cervical Vertebrae; Fractures, Bone; Humans; Spinal Fractures; Spondylitis, Ankylosing
PubMed: 32377994
DOI: 10.1007/s10067-020-05117-0