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Pathology Feb 2023Bordetella hinzii has emerged as an unusual cause of infection in immunocompromised patients, previously linked to zoonotic transmission. Antimicrobial susceptibility...
Bordetella hinzii has emerged as an unusual cause of infection in immunocompromised patients, previously linked to zoonotic transmission. Antimicrobial susceptibility and genetic diversity of B. hinzii are poorly understood. This study reports phenotypic and genomic characteristics of the first four Australian isolates of B. hinzii obtained from elderly immunocompromised patients. Bordetella hinzii isolates were identified by MALDI-TOF and whole genome sequencing (WGS). Antibiotic susceptibility testing was performed using disk diffusion or E-test. Genomes of B. hinzii were analysed in global context. A phylogenetic tree was constructed of all isolates using Roary and a maximum-likelihood tree was generated from the core-snp alignment. Bordetella hinzii minimum inhibitory concentrations (MICs) were largely uniform with high MICs to ampicillin, ceftriaxone and ciprofloxacin and low MICs to meropenem and piperacillin-tazobactam. Genomic analysis of isolate sequences divided strains analysed into two phylogenetically distinct groups, with one Australian B. hinzii isolate (AUS-4) assigned to Group 1, and the remaining isolates (AUS1-AUS3 and AUS-5) to Group 2. Single nucleotide polymorphism (SNP) analysis revealed two isolates, AUS-1 and AUS-2, were closely related with 14 SNP differences between them. All other Australian isolates were unrelated to each and all other isolates from the international dataset. Bordetella hinzii appears to pose a risk to immunocompromised individuals but remains susceptible to extended spectrum β-lactam and carbapenem antibiotics. Genomic analysis suggested a dissemination of genetically distinct strains.
Topics: Humans; Aged; Phylogeny; Australia; Bordetella; Respiratory Tract Infections; Anti-Bacterial Agents; Microbial Sensitivity Tests
PubMed: 36109195
DOI: 10.1016/j.pathol.2022.06.004 -
Annals of Laboratory Medicine Jul 2021
Review
Topics: Asia; Bordetella; Bordetella Infections; Humans; Pneumonia
PubMed: 33536366
DOI: 10.3343/alm.2021.41.4.439 -
Emerging Infectious Diseases Nov 2021Patients with severe acute respiratory syndrome coronavirus 2 infection may have bacterial co-infections, including pneumonia and bacteremia. Bordetella hinzii...
Patients with severe acute respiratory syndrome coronavirus 2 infection may have bacterial co-infections, including pneumonia and bacteremia. Bordetella hinzii infections are rare, may be associated with exposure to poultry, and have been reported mostly among immunocompromised patients. We describe B. hinzii pneumonia and bacteremia in a severe acute respiratory syndrome coronavirus 2 patient.
Topics: Bacteremia; Bordetella; Bordetella Infections; COVID-19; Humans
PubMed: 34388087
DOI: 10.3201/eid2711.211468 -
New Microbes and New Infections Mar 2020We report a novel case of an infection with a pathogen usually detected in poultry, supporting a peripancreatic abscess formation as a complication of an acute...
We report a novel case of an infection with a pathogen usually detected in poultry, supporting a peripancreatic abscess formation as a complication of an acute necrotizing pancreatitis.
PubMed: 32025312
DOI: 10.1016/j.nmni.2020.100650 -
The Journal of International Medical... Jan 2024An increasing number of reports have described the pathogenic nature of several non-classical spp. Among them, and have been implicated in a myriad of...
An increasing number of reports have described the pathogenic nature of several non-classical spp. Among them, and have been implicated in a myriad of respiratory-associated infections in humans and animals. We report the isolation of a genetically close relative of and from the sputum of a woman in her early 60s with extensive bronchiectasis who presented with fever and brown colored sputum. The isolate had initially been identified as by API 20NE, the identification system for non-enteric Gram-negative rod bacteria. Sequencing of the 16S rDNA, , , and genes used in the multilocus sequence typing scheme could not resolve the identity of this isolate. Whole-genome single nucleotide polymorphism analysis positioned the isolate between and in the phylogenetic tree, forming a distinct cluster. Whole-genome sequencing enabled the further identification of this rare organism, and should be considered for wider applications, especially the confirmation of organism identity in the clinical diagnostic microbiology laboratory.
Topics: Humans; Animals; Female; Bordetella Infections; Phylogeny; Bordetella; Bronchiectasis; Respiratory Tract Infections
PubMed: 38216150
DOI: 10.1177/03000605231214464 -
Emerging Infectious Diseases Nov 2021Although Bordetella hinzii coccobacilli is most commonly identified in respiratory tracts of birds and rodents, this organism has occasionally been isolated in human...
Although Bordetella hinzii coccobacilli is most commonly identified in respiratory tracts of birds and rodents, this organism has occasionally been isolated in human infections. We describe a case of B. hinzii spontaneous bacterial peritonitis in Missouri, USA. Whole-genome sequencing of blood and peritoneal fluid isolates confirmed B. hinzii infection.
Topics: Bordetella; Bordetella Infections; Humans; Missouri; Peritonitis
PubMed: 34463239
DOI: 10.3201/eid2711.211428 -
Emerging Infectious Diseases Apr 2022Patients infected with severe acute respiratory syndrome coronavirus 2 might have bacterial and fungal superinfections develop. We describe a clinical case of...
Patients infected with severe acute respiratory syndrome coronavirus 2 might have bacterial and fungal superinfections develop. We describe a clinical case of coronavirus disease with pulmonary aspergillosis associated with Bordetella hinzii pneumonia in an immunocompetent patient in France. B. hinzii infections are rare in humans and develop secondary to immunosuppression or debilitating diseases.
Topics: Bordetella; COVID-19; Humans; Pneumonia; SARS-CoV-2
PubMed: 35318919
DOI: 10.3201/eid2804.212564 -
Neurology. Clinical Practice Oct 2021
PubMed: 34840911
DOI: 10.1212/CPJ.0000000000001122 -
Emerging Microbes & Infections Dec 2023
Topics: Humans; COVID-19; SARS-CoV-2; Bordetella; Bacteremia
PubMed: 36367206
DOI: 10.1080/22221751.2022.2147276 -
Journal of Clinical Microbiology Mar 2021
Topics: Bordetella; Bordetella Infections; Humans; Urinary Tract Infections
PubMed: 33441397
DOI: 10.1128/JCM.02748-20