-
European Journal of Case Reports in... 2019To review infections by
OBJECTIVE
To review infections by
MATERIALS AND METHODS
A 79-year-old male patient, with a chronic aortic valve biological prosthesis, presented to hospital because of fever. First examinations were normal. However, 72 hours later was isolated in blood cultures, and so meropenem was prescribed. Nevertheless, fever and bacteraemia were still present 7 days later.
RESULTS
The transoesophageal echocardiogram revealed an enlarged image suggesting a periprosthetic abscess, confirmed with a PET-CT scan. The patient was sent for cardiac surgery, and biopsy samples confirmed the presence of
CONCLUSION
There are very few cases of infection in humans. Ours is the first described case of endocarditis.
LEARNING POINTS
is commonly detected in poultry but very few cases have been described in humans since it was first isolated in 1994. Some type of immunosuppression is identified in 90% of patients. is frequently resistant to many antibiotics including β-lactams, macrolides, quinolones and cephalosporins. The diagnosis is often difficult using conventional phenotypic methods, so genotypic methods may be necessary for confirmation.Ours is the first described case of infection by with endocardial-vascular involvement. However, cases of endocarditis due to other Bordetella species such as have been documented.
PubMed: 30931262
DOI: 10.12890/2019_000994 -
Genome Announcements Oct 2013Bordetella hinzii colonizes the respiratory tracts of poultry but can also infect immunocompromised humans. Bordetella trematum, however, only infects humans, causing...
Bordetella hinzii colonizes the respiratory tracts of poultry but can also infect immunocompromised humans. Bordetella trematum, however, only infects humans, causing ear and wound infections. Here, we present the first draft genome sequences of strains B. hinzii ATCC 51730 and B. trematum CCUG 13902.
PubMed: 24158552
DOI: 10.1128/genomeA.00838-13 -
Annals of Laboratory Medicine Jul 2021
Review
Topics: Asia; Bordetella; Bordetella Infections; Humans; Pneumonia
PubMed: 33536366
DOI: 10.3343/alm.2021.41.4.439 -
Innate Immunity Aug 2014Endotoxin is recognized as one of the virulence factors of the Bordetella avium bird pathogen, and characterization of its structure and corresponding genomic features...
Endotoxin is recognized as one of the virulence factors of the Bordetella avium bird pathogen, and characterization of its structure and corresponding genomic features are important for an understanding of its role in pathogenicity and for an improved general knowledge of Bordetella spp virulence factors. The structure of the biologically active part of B. avium LPS, lipid A, is described and compared to those of another bird pathogen, opportunistic in humans, Bordetella hinzii, and to that of Bordetella trematum, a human pathogen. Sequence analyses showed that the three strains have homologues of acyl-chain modifying enzymes PagL, PagP and LpxO, of the 1-phosphatase LpxE, in addition to LgmA, LgmB and LgmC, which are required for the glucosamine modification. MALDI mass spectrometry identified a high amount of glucosamine substituting the phosphate groups of B. avium lipid A; this modification was absent from B. hinzii and B. trematum. The acylation patterns of the three lipid As were similar, but they differed from those of Bordetella pertussis and Bordetella parapertussis. They were also found to be close to the lipid A structure of Bordetella bronchiseptica, a mammalian pathogen, only differing from the latter by the degree of hydroxylation of the branched fatty acid.
Topics: Amino Acid Sequence; Bordetella; Bordetella avium; Endotoxins; Fatty Acids; Genome, Bacterial; Glucosamine; Humans; Hydrolysis; Lipid A; Lipopolysaccharides; Molecular Sequence Data; Phosphates
PubMed: 24127384
DOI: 10.1177/1753425913506950 -
Emerging Infectious Diseases Nov 2021Patients with severe acute respiratory syndrome coronavirus 2 infection may have bacterial co-infections, including pneumonia and bacteremia. Bordetella hinzii...
Patients with severe acute respiratory syndrome coronavirus 2 infection may have bacterial co-infections, including pneumonia and bacteremia. Bordetella hinzii infections are rare, may be associated with exposure to poultry, and have been reported mostly among immunocompromised patients. We describe B. hinzii pneumonia and bacteremia in a severe acute respiratory syndrome coronavirus 2 patient.
Topics: Bacteremia; Bordetella; Bordetella Infections; COVID-19; Humans
PubMed: 34388087
DOI: 10.3201/eid2711.211468 -
Genome Announcements Mar 2015Bordetella hinzii is a Gram-negative bacterium known to infect poultry, humans, rabbits, and rodents. It is an opportunistic pathogen in immunocompromised humans, and...
Bordetella hinzii is a Gram-negative bacterium known to infect poultry, humans, rabbits, and rodents. It is an opportunistic pathogen in immunocompromised humans, and some strains cause mild to moderate respiratory disease in turkeys. Little is known as to the degree of genetic diversity within the species or the genetic basis for virulence. Here, we report the genome sequences of six isolates of B. hinzii acquired from humans, rabbits, or turkeys. These data provide a framework for refining the population structure of the genus, establishing relationships among genetically distinct isolates, and developing an understanding of the possible virulence mechanisms of the bacterium.
PubMed: 25792043
DOI: 10.1128/genomeA.00081-15 -
Journal of Bacteriology Nov 2005Bordetella hinzii is a commensal respiratory microorganism in poultry but is increasingly being recognized as an opportunistic pathogen in immunocompromised humans.... (Comparative Study)
Comparative Study
Bordetella hinzii is a commensal respiratory microorganism in poultry but is increasingly being recognized as an opportunistic pathogen in immunocompromised humans. Although associated with a variety of disease states, practically nothing is known about the mechanisms employed by this bacterium. In this study, we show by DNA sequencing and reverse transcription-PCR that both commensal and clinical strains of B. hinzii possess and transcriptionally express cyaA, the gene encoding adenylate cyclase toxin (ACT) in other pathogenic Bordetella species. By Western blotting, we also found that B. hinzii produces full-length ACT protein in quantities that are comparable to those made by B. pertussis. In contrast to B. pertussis ACT, however, ACT from B. hinzii is less extractable from whole bacteria, nonhemolytic, has a 50-fold reduction in adenylate cyclase activity, and is unable to elevate cyclic AMP levels in host macrophages (nontoxic). The decrease in enzymatic activity is attributable, at least in part, to a decreased binding affinity of B. hinzii ACT for calmodulin, the eukaryotic activator of B. pertussis ACT. In addition, we demonstrate that the lack of intoxication by B. hinzii ACT may be due to the absence of expression of cyaC, the gene encoding the accessory protein required for the acylation of B. pertussis ACT. These results demonstrate the expression of ACT by B. hinzii and represent the first characterization of a potential virulence factor of this organism.
Topics: Adenylate Cyclase Toxin; Animals; Bacterial Proteins; Blotting, Western; Bordetella; Calmodulin; Cell Line; Cyclic AMP; DNA, Bacterial; Gene Expression; Hemolysis; Macrophages; Mice; Molecular Sequence Data; Protein Binding; RNA, Bacterial; RNA, Messenger; Reverse Transcriptase Polymerase Chain Reaction; Sequence Analysis, DNA; Virulence Factors, Bordetella
PubMed: 16267282
DOI: 10.1128/JB.187.22.7579-7588.2005 -
Epidemiology and Infection Feb 2000Fifty-seven bacterial isolates previously identified as Bordetella avium or B. hinzii were characterized by restriction enzyme analysis (REA) and/or ribotyping. Twenty...
Fifty-seven bacterial isolates previously identified as Bordetella avium or B. hinzii were characterized by restriction enzyme analysis (REA) and/or ribotyping. Twenty restriction endonucleases were evaluated for REA. Digestion of chromosomal DNA from the 42 B. avium and 15 B. hinzii isolates with HinfI produced 8 and 7 distinct fingerprint profiles, respectively. Digestion with DdeI further discriminated these Bordetella species and produced 12 fingerprint profiles for B. avium and 4 profiles of B. hinzii. In addition, B. avium isolates were clearly distinguishable from B. hinzii isolates by ribotyping with the restriction endonuclease PvuII. The ribotype patterns of these two species of Bordetella were unique when compared to previously reported ribotype patterns for B. bronchiseptica isolates. Since it was possible to discern differences among isolates within each Bordetella species by REA analysis, we suggest that REA could be used in developing a typing system based on the fingerprint profiles generated.
Topics: Bacterial Typing Techniques; Bordetella; DNA Fingerprinting; DNA Restriction Enzymes; DNA, Bacterial; DNA, Ribosomal; Humans; Polymorphism, Restriction Fragment Length; Prohibitins; Restriction Mapping
PubMed: 10722134
DOI: 10.1017/s0950268899003337 -
Emerging Infectious Diseases Dec 2015We report 2 cases of pulmonary Bordetella hinzii infection in immunodeficient patients. One of these rare cases demonstrated the potential transmission of the bacteria...
We report 2 cases of pulmonary Bordetella hinzii infection in immunodeficient patients. One of these rare cases demonstrated the potential transmission of the bacteria from an avian reservoir through occupational exposure and its persistence in humans. We establish bacteriologic management of these infections and suggest therapeutic options if needed.
Topics: Adult; Aged; Animals; Bordetella Infections; Humans; Immunocompromised Host; Lung Diseases; Male; Opportunistic Infections; Poultry; Respiratory Tract Infections
PubMed: 26584467
DOI: 10.3201/eid2112.150400 -
International Journal of Systematic and... Dec 2016Bordetella hinzii is known to cause respiratory disease in poultry and has been associated with a variety of infections in immunocompromised humans. In addition, there...
Bordetella hinzii is known to cause respiratory disease in poultry and has been associated with a variety of infections in immunocompromised humans. In addition, there are several reports of B. hinzii infections in laboratory-raised mice. Here we sequenced and analysed the complete genome sequences of multiple B. hinzii-like isolates, obtained from vendor-supplied C57BL/6 mice in animal research facilities on different continents, and we determined their taxonomic relationship to other Bordetella species. The whole-genome based and 16S rRNA gene based phylogenies each identified two separate clades in B. hinzii, one was composed of strains isolated from poultry, humans and a rabbit whereas the other clade was restricted to isolates from mice. Distinctly different estimated DNA-DNA hybridization values, average nucleotide identity scores, gene content, metabolic profiles and host specificity all provide compelling evidence for delineation of the two species, B. hinzii - from poultry, humans and rabbit - and Bordetella pseudohinzii sp. nov. type strain 8-296-03T (=NRRL B-59942T=NCTC 13808T) that infect mice.
Topics: Animals; Bacterial Typing Techniques; Base Composition; Bordetella; DNA, Bacterial; Fatty Acids; Humans; Mice; Mice, Inbred C57BL; Nucleic Acid Hybridization; Phylogeny; Poultry; RNA, Ribosomal, 16S; Rabbits; Sequence Analysis, DNA
PubMed: 27707434
DOI: 10.1099/ijsem.0.001540