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Medicinal Research Reviews Sep 2023Boron neutron capture therapy (BNCT) is one of the most promising treatments among neutron capture therapies due to its long-term clinical application and... (Review)
Review
Boron neutron capture therapy (BNCT) is one of the most promising treatments among neutron capture therapies due to its long-term clinical application and unequivocally obtained success during clinical trials. Boron drug and neutron play an equivalent crucial role in BNCT. Nevertheless, current clinically used l-boronophenylalanine (BPA) and sodium borocaptate (BSH) suffer from large uptake dose and low blood to tumor selectivity, and that initiated overwhelm screening of next generation of BNCT agents. Various boron agents, such as small molecules and macro/nano-vehicles, have been explored with better success. In this featured article, different types of agents are rationally analyzed and compared, and the feasible targets are shared to present a perspective view for the future of BNCT in cancer treatment. This review aims at summarizing the current knowledge of a variety of boron compounds, reported recently, for the application of BCNT.
Topics: Humans; Boron Neutron Capture Therapy; Boron; Neoplasms; Boron Compounds
PubMed: 37102375
DOI: 10.1002/med.21964 -
Cancer Biotherapy & Radiopharmaceuticals Apr 2023This proceeding article compiles current research on the development of boron delivery drugs for boron neutron capture therapy that was presented and discussed at the... (Review)
Review
This proceeding article compiles current research on the development of boron delivery drugs for boron neutron capture therapy that was presented and discussed at the National Cancer Institute (NCI) Workshop on Neutron Capture Therapy that took place on April 20-22, 2022. The most used boron sources are icosahedral boron clusters attached to peptides, proteins (such as albumin), porphyrin derivatives, dendrimers, polymers, and nanoparticles, or encapsulated into liposomes. These boron clusters and/or carriers can be labeled with contrast agents allowing for the use of imaging techniques, such as PET, SPECT, and fluorescence, that enable quantification of tumor-localized boron and their use as theranostic agents.
Topics: Humans; Boron; Neoplasms; Liposomes; Contrast Media; Boron Neutron Capture Therapy
PubMed: 36350709
DOI: 10.1089/cbr.2022.0060 -
Advances in Nutrition (Bethesda, Md.) Mar 2020
Topics: Animals; Boron; Diet; Humans; Nutritional Physiological Phenomena; Plants, Edible
PubMed: 31639188
DOI: 10.1093/advances/nmz110 -
Chemical Communications (Cambridge,... Jun 2022Recent synthetic achievements have led to 4,4-disubstituted-4-bora-3a,4a-diaza--indacenes (BODIPYs) with varying substituents at the meso, pyrrolic and/or boron sites,... (Review)
Review
Recent synthetic achievements have led to 4,4-disubstituted-4-bora-3a,4a-diaza--indacenes (BODIPYs) with varying substituents at the meso, pyrrolic and/or boron sites, with each influencing photophysical properties and utility. This Feature article gives an overview of chemistry at the boron atom in BODIPYs, highlighting our contributions that evolved from synthetic curiosities and now offer this dipyrrolic skeleton potential across a wider range of applications. We first summarise preparative routes to BODIPYs through complexation of boron with the dipyrrinato ligand. The role of boron in protecting dipyrrins is then discussed, followed by strategies by which to achieve facile substitution at the boron atom.
Topics: Boron; Boron Compounds; Fluorescent Dyes; Pyrroles
PubMed: 35722959
DOI: 10.1039/d2cc02362h -
Bioorganic Chemistry Feb 2024Over the last decades, the medicinal chemistry of boron-based compounds has been extensively explored, designing valuable small molecule drugs to tackle diseases and... (Review)
Review
Over the last decades, the medicinal chemistry of boron-based compounds has been extensively explored, designing valuable small molecule drugs to tackle diseases and conditions, such as cancer, infections, inflammatory and neurological disorders. Notably, boron has proven to also be a valuable element for the development of inhibitors of the metalloenzymes carbonic anhydrases (CAs), a class of drug targets with significant potential in medicinal chemistry. Incorporating boron into carbonic anhydrase inhibitors (CAIs) can modulate the ligand ability to recognize the target and/or influence selectivity towards different CA isoforms, using the tail approach and boron-based tails. The electron-deficient nature of boron and its associated properties have also led to the discovery of novel zinc-binding CAIs, such as boronic acids and the benzoxaboroles, capable of inhibiting the CAs upon a Lewis acid-base mechanism of action. The present manuscript reviews the state-of-the-art of boron-based CAIs. As research in the applications of boron compounds in medicinal chemistry continues, it is anticipated that new boron-based CAIs will soon expand the current array of such compounds. However, further research is imperative to fully unlock the potential of boron-based CAIs and to advance them towards clinical applications.
Topics: Humans; Carbonic Anhydrase Inhibitors; Boron; Carbonic Anhydrases; Protein Isoforms; Neoplasms; Boron Compounds; Structure-Activity Relationship
PubMed: 38000350
DOI: 10.1016/j.bioorg.2023.106976 -
Molecules (Basel, Switzerland) Feb 2020Boron compounds now have many applications in a number of fields, including Medicinal Chemistry. Although the uses of boron compounds in pharmacological science have... (Review)
Review
Boron compounds now have many applications in a number of fields, including Medicinal Chemistry. Although the uses of boron compounds in pharmacological science have been recognized several decades ago, surprisingly few are found in pharmaceutical drugs. The boron-containing compounds epitomize a new class for medicinal chemists to use in their drug designs. Carboranes are a class of organometallic compounds containing carbon (C), boron (B), and hydrogen (H) and are the most widely studied boron compounds in medicinal chemistry. Additionally, other boron-based compounds are of great interest, such as dodecaborate anions, metallacarboranes and metallaboranes. The boron neutron capture therapy (BNCT) has been utilized for cancer treatment from last decade, where chemotherapy and radiation have their own shortcomings. However, the improvement in the already existing (BPA and/or BSH) localized delivery agents or new tumor-targeted compounds are required before realizing the full clinical potential of BNCT. The work outlined in this short review addresses the advancements in boron containing compounds. Here, we have focused on the possible clinical implications of the new and improved boron-based biologically active compounds for BNCT that are reported to have in vivo and/or in vitro efficacy.
Topics: Animals; Boron; Boron Neutron Capture Therapy; Carbon; Humans; Hydrogen
PubMed: 32070043
DOI: 10.3390/molecules25040828 -
Angewandte Chemie (International Ed. in... May 2022Carboranes are boron-carbon molecular clusters that possess unique properties, such as their icosahedron geometry, high boron content, and delocalized three-dimensional... (Review)
Review
Carboranes are boron-carbon molecular clusters that possess unique properties, such as their icosahedron geometry, high boron content, and delocalized three-dimensional aromaticity. These features render carboranes valuable building blocks for applications in supramolecular design, nanomaterials, optoelectronics, organometallic coordination chemistry, and as boron neutron capture therapy (BNCT) agents. Despite tremendous progress in this field, stoichiometric chemical redox reagents are largely required for the oxidative activation of carborane cages. In this context, electrosyntheses represent an alternative strategy for more sustainable molecular syntheses. It is only in recent few years that considerable progress has been made in electrochemical cage functionalization of carboranes, which are summarized in this Minireview. We anticipate that electrocatalysis will serve as an increasingly powerful stimulus within the current renaissance of carborane electrochemistry.
Topics: Boranes; Boron; Carbon
PubMed: 35148009
DOI: 10.1002/anie.202200323 -
Bioorganic & Medicinal Chemistry Jun 2022The incorporation of the "magic" boron atom has been established as an important new strategy in the field of medicinal chemistry as boron compounds have been shown to... (Review)
Review
The incorporation of the "magic" boron atom has been established as an important new strategy in the field of medicinal chemistry as boron compounds have been shown to form various bonds with their biological targets. Currently, a number of boron-based drugs (e.g. bortezomib, crisaborole, and tavaborole) have been FDA approved and are in the clinic, and several other boron-containing compounds are in clinical trials. Boron-based heterocycles have an incredible potential in the ongoing quest for new therapeutic agents owing to their plethora of biological activities and useful pharmacokinetic profiles. The present perspective is intended to review the pharmacological applications of boron-based heterocycles that have been published. We have classified these compounds into groups exhibiting shared pharmacological activities and discussed their corresponding biological targets focusing mainly on the most potent therapeutic compounds.
Topics: Boron; Bortezomib; Chemistry, Pharmaceutical
PubMed: 35453036
DOI: 10.1016/j.bmc.2022.116748 -
International Journal of Molecular... Jun 2020Although very recently, David H [...].
Although very recently, David H [...].
Topics: Agriculture; Boron; Fertilizers; Gene Expression Regulation, Plant; Micronutrients; Plant Proteins; Plant Roots; Plants
PubMed: 32526846
DOI: 10.3390/ijms21114107 -
Molecules (Basel, Switzerland) Aug 2020Boron and silicon-substituted 1,3-dienes and boron and silicon-substituted alkenes and alkynes have been known for years and the last 10 years have seen a number of new... (Review)
Review
Boron and silicon-substituted 1,3-dienes and boron and silicon-substituted alkenes and alkynes have been known for years and the last 10 years have seen a number of new reports of their preparation and use in Diels-Alder reactions. This review first covers boron-substituted dienes and dienophiles and then moves on to discuss silicon-substituted dienes and dienophiles.
Topics: Alkynes; Boron; Catalysis; Cycloaddition Reaction; Models, Molecular; Polyenes; Silicon; Stereoisomerism
PubMed: 32824327
DOI: 10.3390/molecules25163740